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Transcriptional coactivator that specifically associates with either OCT1 or OCT2. Additionally we are shipping POU2AF1 Antibodies (152) and POU2AF1 Kits (3) and many more products for this protein.
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These findings demonstrate for the first time that functional polymorphism in the 3'-UTR of POU2AF1 is associated with susceptibility, and that single-nucleotide polymorphisms interaction with hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-633 affects gene expression and increases the risk of lymphoma.
Oct2 and Bob1 are very reliable in determining B cell lineage in the absence of expression of other pan-B cell markers
these findings suggest a novel function of POU2AF1 as a potential regulator of host defense genes in the human airway epithelium.
It has been identified as a new disease susceptibility gene among Japanese. Though different from Europeans, it is indicated that a B lymphocyte differentiation route shares a common disease developing process. [Review]
Two significant susceptibility loci, TNFSF15 (show TNFSF15 Proteins) (rs4979462) and POU2AF1 (rs4938534) (combined odds ratio [OR] = 1.56, p = 2.84 x 10(-14) for rs4979462.
Data show that Igh 3' enhancer-bound OCA-B and promoter-bound TFII-I mediate promoter-enhancer interactions, in both cis and trans, that are important for Igh transcription.
Twenty-two cases of nodular lymphocyte predominant Hodgkin lymphoma were studied for the immunohistochemical expression of Pax-5 (show PAX5 Proteins), Oct-2, BOB.1, Bcl-6 (show BCL6 Proteins) protein and MUM1/IRF-4 (show IRF4 Proteins).
On multivariate analysis, co-expression of OCT-2/BOB.1 remained predictive for achievement of complete remission and increased risk of relapse.
The expression of the octamer cofactor gene OBF-1 (Bob1/OCA-B) is sufficient to override the silencing effects of the B29 (show CD79B Proteins) silencer, indicating that OBF-1 plays a critical role in B cell-specific B29 (show CD79B Proteins) promoter expression.
enhances transcriptional potential of Oct1 (show POU2F1 Proteins)
Bob1 promotes the development of follicular T helper cells via Bcl6 (show BCL6 Proteins).Bob1 is directly involved in follicular T helper cell differentiation and required for mounting normal T cell-dependent B-cell responses.
Findings indicate octamer transcription factor-1 (show HNF1A Proteins) (Oct1 (show POU2F1 Proteins)) and Oct binding factor 1 protein (OCA-B) as central mediators of CD4 (show CD4 Proteins)(+) T cell memory.
overexpression of DDX60 did not potentiate IFN induction
Loss of Obf1 is associated with IgM-mediated glomerulonephritis.
The transcription factor Bob1 counteracts B cell activation (show BLNK Proteins) and regulates miR (show MLXIP Proteins)-146a in B cells.
Expressing a stable Bob1 mutant in B cells suppresses cell proliferation and induces changes in surface marker expression commonly seen during B-cell differentiation.
Data show that IL-6 (show IL6 Proteins) and IL-21 (show IL21 Proteins) act with different kinetics during the germinal centers (GCs (show UGCG Proteins)) response and that B cells, in an Oct2 (show SLC22A2 Proteins)/OBF-1-dependent manner, can supply the IL-6 (show IL6 Proteins) for early induction of T follicular helper cells (T(FH) development.
OcaB is essential for V(D)J recombination of a subset of Igkappa genes. We show that OcaB modulates recombination by directly enhancing Igkappa gene transcription in vivo.
Data show that the expression of BOB.1/OBF (show IZUMO1 Proteins).1 in peripheral B cells is required for the development of marginal zone B lymphocytes.
Transcriptional coactivator OBF-1 is essential for germinal center formation in Aiolos (show IKZF3 Proteins)-deficient mice; lack of OBF-1 reverses several Aiolos (show IKZF3 Proteins) mutant mouse phenotypes.
Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.
B-cell-specific coactivator OBF-1
, OCT-binding factor 1
, POU domain class 2-associating factor 1
, POU domain, class 2, associating factor 1
, OCT binding factor 1