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POU6F2 encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. Additionally we are shipping POU Class 6 Homeobox 2 Proteins (5) and many more products for this protein.
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Human Polyclonal POU6F2 Primary Antibody for ELISA, WB - ABIN4346896
Perotti, De Vecchi, Testi, Lualdi, Modena, Mondini, Ravagnani, Collini, Di Renzo, Spreafico, Terenziani, Sozzi, Fossati-Bellani, Radice: Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14. in Human mutation 2004
observations suggest that POU6F2 is a tumor suppressor and is involved in hereditary predisposition to Wilms tumor
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
POU class 6 homeobox 2
, POU domain, class 6, transcription factor 2
, Wilms tumor suppressor locus
, retina-derived POU domain factor 1
, retina-derived POU-domain factor-1