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POU4F1 encodes a member of the POU-IV class of neural transcription factors. Additionally we are shipping POU4F1 Proteins (7) and POU4F1 Kits (1) and many more products for this protein.
Showing 10 out of 34 products:
Chicken Polyclonal POU4F1 Primary Antibody for WB - ABIN2780756
Ndisang, Faulkes, Gascoyne, Lee, Ripley, Sindos, Singer, Budhram-Mahadeo, Cason, Latchman: Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a. in Oncogene 2006
Human Polyclonal POU4F1 Primary Antibody for ELISA, WB - ABIN1452060
Dunham, Matthews, Burton, Ashurst, Howe, Ashcroft, Beare, Burford, Hunt, Griffiths-Jones, Jones, Keenan, Oliver, Scott, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey et al.: The DNA sequence and analysis of human chromosome 13. ... in Nature 2004
Brn3a cooperates with activated RAS/RAF (show RAF1 Antibodies) signalling by reducing oncogene (show RAB1A Antibodies)-induced senescence in melanocytic tumourigenesis.
Data indicate that median methylation levels of BCAN (show BCAN Antibodies), HOXD1 (show HOXD1 Antibodies), KCTD8 (show KCTD8 Antibodies), KLF11 (show KLF11 Antibodies), NXPH1 (show NXPH1 Antibodies), POU4F1, SIM1 (show SIM1 Antibodies), and TCF7L1 (show TCF3 Antibodies) were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
PoU4F1 is highly expressed in t(8;21) samples, with AML (show RUNX1 Antibodies)/ETO (show RUNX1T1 Antibodies) appearning to promote some BRN3A expression
BRN3A possesses anti-apoptotic property, and considering the above results, it may be regarded as the key component in promoting tumorigenic growth in the uterine cervical cells.
Ewing sarcoma induce expression of neuronal markers such as BRN3A showing that the function of those same markers may be restricted or controlled in an sarcoma-dependent manner.
Dysregulation of POU4F1 is associated with t(8;21) acute myeloid leukemia (show BCL11A Antibodies).
genomic organization of the Brn-3a locus and the mechanisms that control the expression of two different proteins from one genomic locus
Measurement of Brn-3a levels in smears can be used to detect a significant proportion of cervical lesions that were missed by Pap (show REG3A Antibodies) smear.
These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening.
oncogenic rearrangement of EWS (show EWSR1 Antibodies) to produce EWS (show EWSR1 Antibodies)/Fli-1 (show FLI1 Antibodies) may enhance the antiapoptotic effect of Brn-3a and inhibit its ability to promote neuronal differentiation.
Brn-3a may play a hitherto uncharacterized role in protection of sensory neurons from alphaherpesvirus-induced cell death, which may have implications for different aspects of the alphaherpesvirus life cycle, including latency/reactivation events
Study demonstrates a sequential expression order of NEUROD1 (show NEUROD1 Antibodies)>ISL1 (show ISL1 Antibodies)>POU4F1>POU4F2 (show POU4F2 Antibodies) during the inner ear neurogenesis.
Pou4f1 and pou4f2 (show POU4F2 Antibodies) are dispensable for the long-term survival of adult retinal ganglion cells in mice.
The deficiency of Pou4f1 who perform poorly in motivation-based locomotor behaviors, such as voluntary wheel running and the accelerating rotarod, but show only minor abnormalities in gait and balance and exhibit normal levels of basal locomotion.
Data indicate that Brn3 transcription factors Brn3b (show POU4F2 Antibodies) affects Brn3a and Brn3c (show POU4F3 Antibodies) positive Retinal Ganglion Cells (RGCs) in cell autonomous and non-cell autonomous fashion.
The results demonstrated a critical role for Brn3a in generating dorsal root ganglia sensory neuron diversity and regulating sensory afferent projections to the central targets.
neither Brn3a nor Brn3c (show POU4F3 Antibodies) are expressed in intrinsically photosensitive retinal ganglion cells
Brn3 gene expression patterns in the retina and inner ear, these experiments suggest a deep functional similarity among primary somatosensory neurons, spiral and vestibular ganglion neurons, and retinal ganglion cells
Progressive increase in IOP and loss of Brn3a signals in D2 animals were consistent with glaucoma progression starting after 6 months of age.
An epistatic interaction between Brn3a and Isl1 (show ISL1 Antibodies) is key to sensory neuron specification, in their absence almost all known markers of sensory neurons are lost. Data support the hypothesis that Brn3a and Isl1 (show ISL1 Antibodies) bind to shared enhancers in target genes.
Data show a longitudinal domain positive for both Nkx6.1 (show NKX6-1 Antibodies) and Nkx6.2 that is medial to the Pou4f1-positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon.
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias.
POU domain, class 4, transcription factor 1
, class IV POU-homeodomain protein
, brain-specific homeobox/POU domain protein 3A
, homeobox/POU domain protein RDC-1
, POU class 4 homeobox 1
, POU domain factor
, brain-specific homeobox/POU domain protein 3a