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Protease which may deconjugate SUMO from some substrate proteins (By similarity). Additionally we are shipping PPPDE Peptidase Domain Containing 1 Proteins (5) and many more products for this protein.
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The PPPDE1 could mediate the ubiquitin chain editing of RPS7 (show RPS7 Antibodies), deubiquitinating Lys (show LYZ Antibodies) 48-linked ubiquitination, and finally stabilize RPS7 (show RPS7 Antibodies) proteins.
DESI2 (show PPPDE2 Antibodies) may influence the AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signal in pancreatic cancer.
findings suggest a novel mechanism by which elevated PNAS-4 first causes DNA-dependent protein kinase (show CDK7 Antibodies)-mediated Chk1 (show CHEK1 Antibodies)/2 activation and then results in inhibition of the Cdc25A (show CDC25A Antibodies)-CDK2 (show CDK2 Antibodies)-cyclin E (show CCNE1 Antibodies)/A pathway
hPNAS-4 inhibits proliferation of ovarian cancer cells by inducing S phase arrest and apoptosis via activation of Cdc25A (show CDC25A Antibodies)-Cdk2 (show CDK2 Antibodies)-Cyclin E (show CCNE1 Antibodies)/Cyclin A (show CCNA2 Antibodies) axis and mitochondrial dysfunction-mediated caspase (show CASP3 Antibodies)-dependent and -independent apoptotic pathways.
PNAS-4 is not a p53 (show TP53 Antibodies) target, but overexpression of PNAS-4 is correlated to p53 (show TP53 Antibodies) inactivity in colorectal cancer.
overexpression of human PNAS4 induced apoptosis and arrested cell cycle in S phase in A549 human lung adenocarcinoma cells.
expression regulation and biological functions of PPPDE1 in development and carcinogenesis.
PNAS4 was not involved in mice brain development and apoptosis.
overexpression of mouse PNAS4 significantly suppressed Lewis lung carcinoma growth and prolonged survival time through induction of tumor cell apoptosis
PNAS-4 gene maps to pig chromosome 10, q11-16, and is upregulated after weaning. Homozygous pigs have a higher fat content.
Protease which may deconjugate SUMO from some substrate proteins (By similarity).
PPPDE peptidase domain-containing protein 1
, UPF0326 protein FAM152A
, family with sequence similarity 152, member A
, PPPDE peptidase domain containing 1
, desumoylating isopeptidase 1