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PR Domain Containing 1, with ZNF Domain Proteins (PRDM1)

PRDM1 encodes a protein that acts as a repressor of beta-interferon gene expression. Additionally we are shipping PR Domain Containing 1, with ZNF Domain Antibodies (161) and PR Domain Containing 1, with ZNF Domain Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRDM1 639 O75626
PRDM1 12142 Q60636
PRDM1 309871  
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Top PR Domain Containing 1, with ZNF Domain Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$823.90
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$841.50
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$862.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$999.22
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,030.69
Details

PRDM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)
,
Rat (Rattus)

More Proteins for PR Domain Containing 1, with ZNF Domain (PRDM1) Interaction Partners

Rabbit PR Domain Containing 1, with ZNF Domain (PRDM1) interaction partners

  1. BLIMP1 (PRDM1)expression begins throughout the hypoblast at stage 1 and emerges in single primordial germ cell (PGC (show PGC Proteins)) precursors in the posterior epiblast at stage 2.

Fruit Fly (Drosophila melanogaster) PR Domain Containing 1, with ZNF Domain (PRDM1) interaction partners

  1. Blimp-1 gene is transcribed during prepupal development when the ecdysteroid titer is high, but the expressed mRNA degrades rapidly.

  2. Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo.

  3. These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.

Zebrafish PR Domain Containing 1, with ZNF Domain (PRDM1) interaction partners

  1. Expression of the M- and N-cadherins, previously implicated in driving adaxial cell migration, is largely unaffected by loss of Prdm1a function, suggesting that differential cadherin expression is not sufficient for adaxial cell migration

  2. Prdm1a functions as both a transcriptional activator and repressor during neural crest development.

  3. identify sox6 cis (show CISH Proteins)-regulatory sequences that drive fast-twitch-specific expression in a Prdm1a-dependent manner

  4. prdm1a expression is upregulated in the absence of Notch (show NOTCH1 Proteins) function, and inhibiting Notch (show NOTCH1 Proteins) signaling fails to rescue prdm1a mutants

  5. prdm1a Regulates sox10 (show SOX10 Proteins) and islet1 (show ISL1 Proteins) in the development of neural crest and Rohon-Beard sensory neurons.

  6. These results indicate an essential role for prdm1a in the development of the zebrafish craniofacial skeleton.

  7. Here we show that the gene u-boot (ubo), a mutation in which disrupts the induction of embryonic slow-twitch fibers, encodes the zebrafish homolog of Blimp-1

  8. The transcriptional regulator Blimp-1 plays a role in the inception of Neural Crest progenitor fate through BMP signalling.

  9. prdm1/blimp1 has roles in embryo patterning and organogenesis

  10. prdm1 functions to promote the cell fate specification of both neural crest cells and sensory neurons

Human PR Domain Containing 1, with ZNF Domain (PRDM1) interaction partners

  1. Blimp-1 regulates the transcription of CS1 (show CSH1 Proteins) gene in NK and B cell lines from multiple myeloma and diffuse large B cell lymphoma patients.

  2. Antineoplastic effects of liposomal short interfering RNA treatment targeting BLIMP1/PRDM1 in primary effusion lymphoma.

  3. The interaction between EBV-miR (show MLXIP Proteins)-BHRF1-2 and PRDM1 may be one of the mechanisms by which EBV-miRBHRF1-2 promotes Epstein-Barr virus lymphomagenesis.

  4. heterozygous deletion of 6q21 and/or PRDM1 was frequently detected in extranodal NK/T cell lymphoma, nasal type and correlated with downregulation of PRDM1.

  5. KLF4 (show KLF4 Proteins), together with BLIMP1, plays a critical role in mediating lytic Epstein-Barr virus reactivation in epithelial cells.

  6. Our findings suggest a previously unrecognized role of PRDM1 and human parvovirus B19 in the pathogenesis of Hashimoto thyroiditis

  7. Blimp1-deficient effector T cells fail to produce IL-10 (show IL10 Proteins), and deficiency in Tr-1 (show TNFRSF11B Proteins) cell function leads to uncontrolled Th17 cell-driven CNS pathology without the need to stabilize the Th17 phenotype with IL-23 (show IL23A Proteins)

  8. Positional mapping of PRKD1 (show PRKD1 Proteins), NRP1 (show NELL1 Proteins) and PRDM1 as novel candidate disease genes in truncus arteriosus

  9. Blimp-1 expression in dendritic cells can alter an innate inflammatory response by modulating the activation of myeloid cells

  10. Data show that vascular (show FOXG1 Proteins) endothelial growth factor (VEGF) upregulates the transcription repressor PRD1-BF1 protein in endothelial cells.

Mouse (Murine) PR Domain Containing 1, with ZNF Domain (PRDM1) interaction partners

  1. The escape of a fraction of Primordial germ cells from the Prdm1 deletion was sufficient to recover fairly normal germ cell pools, both in male and female adults

  2. There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.

  3. Reduction of HDAC3 (show HDAC3 Proteins) or NCoR1 (show NCOR1 Proteins) expression by RNA interference in B cells resulted in an increased Prdm1 mRNA expression.

  4. TCF1 (show HNF1A Proteins) is required for the T follicular helper cell response to viral infection functioning through negative feedback loops with IL-2 (show IL2 Proteins) and Blimp1.

  5. Blimp1 was dispensable for survival of plasma cells. Blimp-1-deficient plasma cells retained their transcriptional identity but lost the ability to secrete antibody. Blimp-1 regulated many components of the unfolded protein response.

  6. Blimp1 promoted the migration and adhesion of plasmablasts, silenced B cell-specific gene expression, antigen presentation and class-switch recombination in plasmablasts, and induced immunoglobulin gene transcription and secretion.

  7. In a genetically engineered mouse model of soft tissue sarcoma that loss of GCN2 has no effect on tumor growth or animal survival.

  8. Blimp-1 likely has distinct gene-regulating activities depending on the inflammatory or anti-inflammatory enhancer landscape created by a multi-factorial transcriptional complex

  9. From these results, we defined the distinct functions of Blimp-1 and Akt (show AKT1 Proteins) and provided mechanistic insights into the acquisition of pluripotency in Primordial germ cells.

  10. LPS (show TLR4 Proteins)-PG completely abrogates RANKL (show TNFSF11 Proteins)-induced gene expression of B lymphocyte-induced maturation protein-1 (Blimp1), a global transcriptional repressor of anti-osteoclastogenic genes encoding Bcl6 (show BCL6 Proteins), IRF8 (show IRF8 Proteins), and MafB (show MAFB Proteins)

PR Domain Containing 1, with ZNF Domain (PRDM1) Protein Profile

Protein Summary

This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.

Gene names and symbols associated with PRDM1

  • PR domain containing 1, with ZNF domain (PRDM1)
  • PR domain containing 1, with ZNF domain (LOC100338324)
  • Blimp-1 protein (Blimp-1)
  • CG5249 gene product from transcript CG5249-RB (Blimp-1)
  • blimp-1 (CpipJ_CPIJ007425)
  • PR domain containing 1a, with ZNF domain (prdm1a)
  • PR domain containing 1, with ZNF domain (prdm1)
  • B lymphocyte induced maturation protein 1 (prdm1)
  • PR domain containing 1, with ZNF domain (Prdm1)
  • Blimp-1 protein
  • BLIMP1 protein
  • CG5249 protein
  • dBlimp-1 protein
  • dBlimp1 protein
  • Dmel\\CG5249 protein
  • GB11750 protein
  • MGC52536 protein
  • nrd protein
  • PRDI-BF1 protein
  • PRDM1 protein
  • ubo protein
  • wu:fb99c12 protein
  • xblimp1 protein
  • zgc:91885 protein
  • ZNFPR1A1 protein

Protein level used designations for PRDM1

PR domain containing 1, with ZNF domain , Blimp-1 protein , Blimp-1-PA , Blimp-1-PB , Blimp-1-PC , Blimp-1-PD , Blimp-1-PE , CG5249-PA , CG5249-PB , CG5249-PC , CG5249-PD , CG5249-PE , dBlimp1 , blimp-1 , B lymphocyte-induced maturation protein 1 , PR domain zinc finger protein 1 , PR domain-containing 1 , U boot , narrowminded , u-boot , B lymphocyte induced maturation protein 1 , PR domain zinc finger protein 1-like , B-lymphocyte-induced maturation protein 1 , BLIMP-1 , PRDI-binding factor-1 , beta-interferon gene positive-regulatory domain I binding factor , B lymphocyte induced maturation protein , PR domain containing 1 with ZNF domain , PR domain-containing protein 1 , beta-interferon gene positive regulatory domain I-binding factor

GENE ID SPECIES
100154284 Sus scrofa
100338324 Oryctolagus cuniculus
408295 Apis mellifera
38638 Drosophila melanogaster
6039439 Culex quinquefasciatus
323473 Danio rerio
380265 Xenopus laevis
446070 Takifugu rubripes
462904 Pan troglodytes
493207 Xenopus (Silurana) tropicalis
696757 Macaca mulatta
100071967 Equus caballus
100401970 Callithrix jacchus
100442042 Pongo abelii
100474321 Ailuropoda melanoleuca
100548130 Meleagris gallopavo
100560171 Anolis carolinensis
100585120 Nomascus leucogenys
100619194 Monodelphis domestica
639 Homo sapiens
12142 Mus musculus
445340 Gallus gallus
481947 Canis lupus familiaris
538384 Bos taurus
309871 Rattus norvegicus
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