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PR Domain Containing 14 Proteins (PRDM14)

PRDM14 encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. Additionally we are shipping PRDM14 Antibodies (72) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat PRDM14 PRDM14 297769  
PRDM14 383491 E9Q3T6
PRDM14 63978 Q9GZV8
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Top PRDM14 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus Human DYKDDDDK Tag Recombinant PRDM14 protein gel. PRDM14 protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
$484.17
Details

PRDM14 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for PR Domain Containing 14 (PRDM14) Interaction Partners

Mouse (Murine) PR Domain Containing 14 (PRDM14) interaction partners

  1. This repressive function is mediated through an ETO (show RUNX1T1 Proteins)-family co-repressor Mtgr1 (show CBFA2T2 Proteins), which tightly binds to the pre-SET/SET domains of Prdm14 and co-occupies its genomic targets in mouse embryonic stem cells.

  2. the H3K27-specific demethylase Utx (show KDM6A Proteins) regulates the expression of the master regulators for XCI and XCR: Prdm14, Tsix, and Xist.

  3. Both TET1 (show TET1 Proteins) and TET2 are required for the repression of embryonic stem cells differentiation by PRDM14.

  4. Upregulation of Prdm14 results in a highly homogeneous population of authentic pluripotent colonies and prevents the abnormal silencing of the Dlk1 (show DLK1 Proteins)-Dio3 (show DIO3 Proteins) locus.

  5. PRDM14 is heterogeneously expressed in 4-cell-stage embryos. Forced expression of PRDM14 at the 2-cell stage leads to increased H3R26me2 and can induce a pluripotent ICM fate.

  6. PRDM14-induced leukemic cells contain high levels of activated NOTCH1 (show NOTCH1 Proteins) and downstream NOTCH1 (show NOTCH1 Proteins) targets, including MYC (show MYC Proteins) and HES1, and are sensitive to pharmacological inhibition of NOTCH1 (show NOTCH1 Proteins) with the gamma-secretase inhibitor DAPT

  7. PRDM14 physically interacts with TET1 (show TET1 Proteins) and TET2 and enhances the recruitment of TET1 (show TET1 Proteins) and TET2 at target loci. Knockdown of TET1 (show TET1 Proteins) and TET2 impaired transcriptional regulation and DNA demethylation by PRDM14.

  8. Tsix and PRDM14 directly link X-chromosome reactivation to stem cell pluripotency.

  9. Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation (show HELLS Proteins).

  10. PRDM14, ensures naive pluripotency through antagonizing activation of the FGFR (show FGFR2 Proteins) signaling by the core pluripotency transcriptional circuitry, and repressing expression of DNA methyltransferases that modify the epigenome to a primed epiblast-like state.

Zebrafish PR Domain Containing 14 (PRDM14) interaction partners

  1. Prdm14 regulates Caudal primary axon outgrowth through activation of islet2 expression.

Human PR Domain Containing 14 (PRDM14) interaction partners

  1. In response to cytokines, pluripotent stem cells differentiate first into a heterogeneous mesoderm-like cell population and then into Primordial Germ cell-Like Cells, which exhibit minimal PRDM14 expression.

  2. The contribution of methylation-mediated gene silencing of PRDM14 to apoptosis evasion in HPV-positive cancer cells offers novel therapeutic options for HPV-induced cancers.

  3. PRDM14 associated with cell differentiation in NSCLC.

  4. Study reveals a repressive role of PRDM14 in the maintenance and induction of pluripotency and identifies PRDM14 as a new regulator of PRC2.

  5. The high expression of PRDM14 in non-small cell lung cancer is associated with differentiation and histological type.

  6. novel hESC regulators wherein PRDM14 exemplifies a key transcription factor required for the maintenance of hESC identity and the reacquisition of pluripotency in human somatic cells

  7. PRDM14 mRNA is overexpressed in about two thirds of breast cancers; moreover, immunohistochemical analysis showed that expression of PRDM14 protein is also up-regulated.

  8. These results suggest that PRDM14 is involved in the maintenance of the self-renewal of human ES cells by suppression of gene expression.

PRDM14 Protein Profile

Protein Summary

This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer.

Gene names and symbols associated with PRDM14

  • PR domain containing 14 (Prdm14)
  • PR domain containing 14 (PRDM14)
  • PR domain containing 14 (prdm14)
  • PR domain containing 14 (LOC100347807)
  • fc16b12 protein
  • PFM11 protein
  • PRDM14 protein
  • prmd14 protein
  • wu:fc16b12 protein

Protein level used designations for PRDM14

PR domain containing 14 , PR domain zinc finger protein 14 , PR domain-containing protein 14 , PR domain zinc finger protein 14-like

GENE ID SPECIES
297769 Rattus norvegicus
383491 Mus musculus
428362 Gallus gallus
464224 Pan troglodytes
563151 Danio rerio
693324 Macaca mulatta
100347807 Oryctolagus cuniculus
100411718 Callithrix jacchus
100457355 Pongo abelii
100469835 Ailuropoda melanoleuca
100519142 Sus scrofa
100028758 Monodelphis domestica
100062473 Equus caballus
100584766 Nomascus leucogenys
63978 Homo sapiens
486988 Canis lupus familiaris
100140032 Bos taurus
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