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anti-PR Domain Containing 16 (PRDM16) Antibodies

The reciprocal translocation t(1\;3)(p36\;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Additionally we are shipping PRDM16 Proteins (5) and PRDM16 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PRDM16 63976 Q9HAZ2
PRDM16 70673 A2A935
PRDM16 100366024  
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Top anti-PRDM16 Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of PRDM16 in rat brain tissue with AP30689PU-N PRDM16 antibody at 2.5 μg/ml. Western blot analysis of PRDM16 in rat brain tissue lysate with AP30689PU-N PRDM16 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PRDM16 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate WB Suggested Anti-PRDM16  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$221.76
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit APC IHC, ELISA   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA   100 μL Log in to see 8 to 10 Days
$383.17
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB 50 μg Log in to see 11 to 13 Days
$541.80
Details

PRDM16 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Rat (Rattus)
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Top referenced anti-PRDM16 Antibodies

  1. Human Polyclonal PRDM16 Primary Antibody for EIA, IHC (p) - ABIN500533 : Seale, Bjork, Yang, Kajimura, Chin, Kuang, Scimè, Devarakonda, Conroe, Erdjument-Bromage, Tempst, Rudnicki, Beier, Spiegelman: PRDM16 controls a brown fat/skeletal muscle switch. in Nature 2008 (PubMed)
    Show all 4 references for ABIN500533

  2. Human Polyclonal PRDM16 Primary Antibody for ELISA, WB - ABIN184809 : Mochizuki, Shimizu, Nagasawa, Tanaka, Taniwaki, Yokota, Morishita: A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. in Blood 2000 (PubMed)

More Antibodies against PRDM16 Interaction Partners

Zebrafish PR Domain Containing 16 (PRDM16) interaction partners

  1. Prdm3 (show MECOM Antibodies) and prdm16 are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Cow (Bovine) PR Domain Containing 16 (PRDM16) interaction partners

  1. Animals with the homozygote PRDM16 genotype had lower body weight and average daily gain than those with the other genotypes.

  2. The genetic variation within PRDM16 gene in 1031 Chinese indigenous bovine, was analyzed.

Human PR Domain Containing 16 (PRDM16) interaction partners

  1. Our results suggest that K568 SUMOylation of sPRDM16 plays an important role in the progression of acute myeloid leukemia (show BCL11A Antibodies).

  2. Results show that PRDM16 overexpression was highly recurrent in de novo paediatric AML (show RUNX1 Antibodies) and is associated with adverse outcome

  3. PRDM16 might contribute to maintain adipose tissue "white fat" gene expression profile and systemic metabolic homeostasis.

  4. EVI1 (show MECOM Antibodies) and MEL1 are homolog genes whose transcriptional activations by chromosomal translocations have roles in Japanese pediatric acute myeloid leukemia (show BCL11A Antibodies)

  5. Three novel loci were identified in East Asians with cardiac arrhythmias: rs2483280 (PRDM16 locus) and rs335206 (PRDM6 (show PRDM6 Antibodies) locus) were associated with QRS (show QARS Antibodies) duration; and rs17026156 (SLC8A1 (show SLC8A1 Antibodies) locus) correlated with PR interval.

  6. Genetic analyses uncovered the importance of the PRDM16 gene in the regulation of lean body mass.

  7. MED1 (show MED1 Antibodies) is required for optimal PRDM16-induced Ucp1 (show UCP1 Antibodies) expression

  8. PRDM2 (show PRDM2 Antibodies), PRDM5 (show PRDM5 Antibodies), PRDM16 promoters are methylated and their expression is suppressed in lung cancer cells.

  9. Mutations in gene encoding the transcriptional co-activator PRDM16 may be a cause of left-ventricular noncompaction and dilated cardiomyopathy.

  10. The rs2651899 variant in PRDM16 plays a role in Chinese common migraine susceptibility.

Mouse (Murine) PR Domain Containing 16 (PRDM16) interaction partners

  1. We further show that Cdkn1c (show CDKN1C Antibodies) is required for post-transcriptional accumulation of the brown fat determinant PR domain containing 16 (PRDM16) and that CDKN1C (show CDKN1C Antibodies) and PRDM16 co-localise to the nucleus of rare label-retaining cell within iBAT (show SLC10A2 Antibodies).

  2. PRDM16-induced C2C12 transdifferentiation is associated with alterations in CpG methylation of myogenic factors, and PR domain affects both myogenesis and adipogenesis with modified histone methylation marks on MyoD (show MYOD1 Antibodies) and PPARgamma (show PPARG Antibodies) promoters

  3. PRDM16 deficiency in BAT (show BAAT Antibodies) reduces MED1 (show MBD4 Antibodies) binding at PRDM16 target sites and causes a fundamental change in chromatin architecture at key brown fat-selective genes

  4. Prdm16 and Prdm3 (show MECOM Antibodies) control postnatal BAT (show BAAT Antibodies) identity and function.

  5. Study reveals that Prdm16 expression is regulated through Gcn5 (show KAT2A Antibodies)/PCAF (show KAT2B Antibodies) during brown adipogenesis.

  6. these studies define the transcriptional pathways involved in HOXB4 (show HOXB4 Antibodies) HSC (show FUT1 Antibodies) expansion in vivo and identify repression of Prdm16 transcription as a mechanism by which expanding HSCs avoid leukemic transformation.

  7. miR (show MLXIP Antibodies)-133 links to energy balance through targeting Prdm16.

  8. These findings indicate that PRDM16 and beige (show LYST Antibodies) adipocytes are required for the "browning" of white fat and the healthful effects of subcutaneous adipose tissue.

  9. adult satellite cells give rise to brown adipocytes and that microRNA-133 regulates the choice between myogenic and brown adipose determination by targeting the 3'UTR (show UTS2R Antibodies) of Prdm16.

  10. When expressed at elevated levels in brown fat, TLE3 counters Prdm16, suppressing brown-selective genes and inducing white-selective genes, resulting in impaired fatty acid oxidation and thermogenesis.

PRDM16 Antigen Profile

Protein Summary

The reciprocal translocation t(1\;3)(p36\;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene names and symbols associated with PRDM16

  • PR domain containing 16 (PRDM16) antibody
  • PR domain containing 16 (prdm16) antibody
  • PR domain containing 16 (Prdm16) antibody
  • 5730557K01Rik antibody
  • C130091E20 antibody
  • csp1 antibody
  • mel1 antibody
  • mKIAA1675 antibody
  • PFM13 antibody
  • PRDM16 antibody
  • wu:fc09g08 antibody

Protein level used designations for PRDM16

PR domain containing 16 , fc09g08 , PR domain zinc finger protein 16-like , MDS1/EVI1-like gene 1 , PR domain zinc finger protein 16 , transcription factor MEL1 , PR domain-containing protein 16 , line 27

GENE ID SPECIES
419388 Gallus gallus
457227 Pan troglodytes
559174 Danio rerio
100060844 Equus caballus
100137803 Bos taurus
100481590 Ailuropoda melanoleuca
100592850 Nomascus leucogenys
63976 Homo sapiens
70673 Mus musculus
100366024 Rattus norvegicus
479582 Canis lupus familiaris
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