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The protein encoded by PRDM5 is a transcription factor of the PR-domain protein family. Additionally we are shipping PRDM5 Antibodies (83) and many more products for this protein.
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The current study revealed a novel mutation in the PRDM5 gene in a Brittle cornea syndrome (BCS) family and recurrent mutation in a sporadic BCS patient.
Genetic variants in PRDM5 can lead to various syndromic and nonsyndromic disorders affecting the anterior segment of the eye.
Defective interaction of PRDM5 with repressive complexes, and dysregulation of H3K9me2, play a role in PRDM5-associated disease.
Reduced expression of PRDM5 was observed in the cornea and retina of brittle cornea syndrome patients.
These data suggest that PRDM5 is a relevant tumour suppressor gene that is frequently targeted in colorectal tumourigenesis.
PRDM2 (show PRDM2 Proteins), PRDM5, PRDM16 (show PRDM16 Proteins) promoters are methylated and their expression is suppressed in lung cancer cells.
Data provide the first causal link between Prdm5 loss and intestinal carcinogenesis, and uncover an extensive and novel PRDM5 target repertoire likely facilitating the tumor-suppressive functions of PRDM5.
Promoter methylation-mediated downregulation of PRDM5 contributes to the development of lung squamous cell carcinoma.
Frequent epigenetic silencing of PRDM5 is involved in multiple tumorigeneses, which could serve as a tumor biomarker
ZNF469 and PRDM5, two genes that when mutated cause brittle cornea syndrome, participate in the same regulatory pathway.
Prdm5 is expressed specifically in the area of the forming neurocranium during craniofacial development.
PRDM5 regulates the expression of components of both canonical and non canonical wnt (show WNT2 Proteins) pathways and negatively modulates wnt (show WNT2 Proteins) signaling in vivo
These data indicate how Prdm5 modulates transcription by interacting with factors involved in genome organization in mouse embryonic stem cells.
we show that Prdm5 controls both Collagen I transcription and fibrillogenesis by binding inside the Col1a1 gene body and maintaining RNA polymerase II occupancy
The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis.
PR domain containing 5
, PR domain zinc finger protein 5-like
, PR domain zinc finger protein 5
, un-named hi61
, unm hi61
, PR domain-containing protein 5