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PR Domain Containing 9 Proteins (PRDM9)

The PR domain is a protein-protein interaction module of about 100 amino acids. Additionally we are shipping PRDM9 Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRDM9 56979 Q9NQV7
PRDM9 213389  
PRDM9 365155 P0C6Y7
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Top PRDM9 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,337.67
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

PRDM9 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

Rat (Rattus) ,

More Proteins for PR Domain Containing 9 (PRDM9) Interaction Partners

Cow (Bovine) PR Domain Containing 9 (PRDM9) interaction partners

  1. We fine-map three QTL and present strong evidence that genetic variants in REC8 (show REC8 Proteins) and RNF212 (show RNF212 Proteins) influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.

Chimpanzee PR Domain Containing 9 (PRDM9) interaction partners

  1. findings implicate the PRDM9 gene in meiotic recombination; involvement of PRDM9, which causes histone H3 (show HIST3H3 Proteins) lysine 4 trimethylation, implies that there is a common mechanism for recombination hotspots in eukaryotes

Human PR Domain Containing 9 (PRDM9) interaction partners

  1. The article outlines the role of PRDM9 in fertility.

  2. PRDM9 protein variants form functional heteromeric complexes which can bind hotspots sequences. When a heteromeric complex binds at a hotspot of one PRDM9 variant, the other PRDM9 variant, which would otherwise not bind, methylates hotspot nucleosomes

  3. subspecies-specific degradation of PRDM9 binding sites by meiotic drive, which steadily increases asymmetric PRDM9 binding, has impacts beyond simply changing hotspot positions, and strongly support a direct involvement in hybrid infertility

  4. Alignment of Neandertal and Denisovan sequences suggests that PRDM9 in archaic hominins was closely related to present-day human alleles that are rare and specific to African populations.

  5. This depletion of PRDM9 genomic targets is expected to decrease fitness, and thereby to favor new PRDM9 alleles binding different motifs

  6. Results confirm an association between rare variant PRDM9 alleic forms and childhood ALL

  7. Overexpression of PRDM9 in HEK293 cells also resulted in a significant increase in trimethylated H3K36 and H3K4 further confirming our in vitro observations

  8. We identified PRDM9 as being associated with unusual recombination patterns and discovered a substantial excess of rare allelic forms of PRDM9 in two independent acute lymphoblastic leukemia cohorts.

  9. Recombination regulator PRDM9 influences the instability of its own coding sequence in humans.

  10. observed a increased frequency of PRDM9 variants in parents who transmitted de novo 7q11.23 deletions to their offspring. These data suggest that certain PRDM9 alleles may be associated with an increased susceptibility to recurrent 7q11.23 microdeletions

Mouse (Murine) PR Domain Containing 9 (PRDM9) interaction partners

  1. genetic factors, the Prdm9 gene and the Hstx2/Meir1 genomic locus, indicate a link between meiotic recombination and hybrid sterility

  2. PRDM9 protein variants form functional heteromeric complexes which can bind hotspots sequences. When a heteromeric complex binds at a hotspot of one PRDM9 variant, the other PRDM9 variant, which would otherwise not bind, methylates hotspot nucleosomes

  3. results on the developmental time course for nuclear localization of PRDM9 establish its direct window of function and demonstrate the independence of chromosome axial element formation from concurrent PRDM9-mediated activation of recombination hotspots

  4. Together these data support a model where haplotype-specific PRDM9 binding directs biased gene conversion at hotspots, ultimately leading to hotspot erosion.

  5. M. musculus Prdm9 displays an extraordinarily high level of polymorphism, particularly in regions encoding zinc finger repeats, which recognize recombination hotspots.

  6. Our results indicate extended functional consequences of Prdm9-Chr X intersubspecific incompatibility on the fertility of hybrids.

  7. PRDM9 binding actively reorganizes nucleosomes into a symmetrical pattern, creating an extended nucleosome-depleted region.

  8. Histone methyltransferase PRDM9 operates on histone octamers as its substrates.

  9. the Prdm9(B6) allele probably takes part in posttranscriptional dominant-negative hybrid interaction(s) absent in the parental strains.

  10. PRDM9 determines the positions of practically all hotspots in the mouse genome, with the exception of the pseudo-autosomal region (PAR (show AFG3L2 Proteins)); an unexpected role of the PRDM9 protein in sequestering the recombination machinery away from gene-promoter regions and other functional genomic elements

PRDM9 Protein Profile

Protein Summary

The PR domain is a protein-protein interaction module of about 100 amino acids. PR domain-containing proteins, such as PRDM9, are often involved in transcriptional regulation (Jiang and Huang, 2000

Gene names and symbols associated with PR Domain Containing 9 Proteins (PRDM9)

  • PR domain containing 9 (LOC783410)
  • PR domain containing 9 (prdm9)
  • PR domain containing 9 (PRDM9)
  • PR domain containing 9 (Prdm9)
  • BC012016 protein
  • Dsbc1 protein
  • G1-419-29 protein
  • Meisetz protein
  • MSBP3 protein
  • PFM6 protein
  • Prdm7 protein
  • PRDM9 protein
  • PRMD9 protein
  • Rcr1 protein
  • repro7 protein
  • XFDL141 protein
  • zgc:63970 protein
  • ZNF436 protein
  • ZNF899 protein

Protein level used designations for PR Domain Containing 9 Proteins (PRDM9)

PR domain containing 9 , histone-lysine N-methyltransferase PRDM9 , PR domain-containing protein 9 , PR domain zinc finger protein 9 , XFDL 141 , zinc finger protein XFDL 141 , zinc finger protein 436 , PR domain containing 7-like , histone-lysine N-methyltransferase PRDM9-like , minisatellite binding protein 3 (115kD) , minisatellite binding protein 3, 115kDa , PR-domain zinc finger protein , VPR domain containing 9 , hybrid sterility protein 1 , meiosis-induced factor containing a PR/SET domain and zinc-finger motif , PR domain containing 7

GENE ID SPECIES
783410 Bos taurus
393876 Danio rerio
397848 Xenopus laevis
416664 Gallus gallus
461944 Pan troglodytes
516002 Bos taurus
694222 Macaca mulatta
740550 Pan troglodytes
100135246 Xenopus (Silurana) tropicalis
100190914 Bos taurus
100380788 Salmo salar
100440639 Pongo abelii
56979 Homo sapiens
213389 Mus musculus
365155 Rattus norvegicus
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