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PROP1 encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Additionally we are shipping PROP1 Antibodies (23) and PROP1 Kits (3) and many more products for this protein.
Showing 9 out of 9 products:
Data show that human paired like homeodomain factor 1 (PROP1) can substitute functionally for mouse Prop1.
endocochlear potential and KCNJ10 (show KCNJ10 Proteins) immunostaining in the stria vascularis are indistinguishable from wild type, and no differences in neurofilament or synaptophysin (show SYP Proteins) staining are evident in Prop1(df) mutants
Data report the spatial and temporal regulation of Otx2 (show OTX2 Proteins) in normal mice and Prop1 mutant.
Several components of the main GH-signaling pathways exhibit enhanced sensitivity to the hormone in liver and muscle of Ames dwarf mice.
Studies suggest that TLE1 (show TLE1 Proteins) and TLE3 might also play roles independent of HESX1 (show HESX1 Proteins) by interacting with other transcription factors like PROP1.
Lhx4 (show LHX4 Proteins) and Prop1 have critical, but mechanistically different roles in specification and expansion of specialized anterior pituitary cells
Tcf4 (show TCF4 Proteins) and Aes (show AES Proteins) influence pituitary growth and development, and place Tcf4 (show TCF4 Proteins) and Tle3 in the genetic hierarchy with Prop1
PROP1 has a role in pituitary gland growth
variation in PROP1 expression could affect the growth spurt (show BPIFA1 Proteins) and the onset of puberty in humans.
Prop-1 modulates the synthesis of FSH (show BRD2 Proteins) at the transcriptional level.
A novel heterozygous mutation in the HESX1 (show HESX1 Proteins) gene and a novel homozygous mutation in the PROP1 gene were detected in 2 pedigrees with combined pituitary hormone (show CGA Proteins) deficiency
The c.301_302delAG homozygous genotype had a high frequency of 38%, reaching 100% in group with familial cases of multiple pituitary hormone (show CGA Proteins) deficiency and 16% in group with sporadic forms of MPHD.
investigated the specific mutations in PROP1, POU1F1 (show POU1F1 Proteins), LHX3 (show LHX3 Proteins), and HESX1 (show HESX1 Proteins) genes in patients with combined pituitary hormone (show CGA Proteins) deficiency (CPHD) in Turkey
The p.R73C PROP1 mutation was the most frequent mutation in Congenital hypopituitarism in a Moroccan cohort.
The various levels of specific miRNAs, particularly miR (show MLXIP Proteins)-593 and miR (show MLXIP Proteins)-511 whose direct target is the PROP1 gene, may serve as a non-invasive diagnostic biomarkers for children with CPHD.
mutations in the PROP-1 gene in cases with CPHD were expected to be more prevalent in our population due to consanguinity, but it was found that these mutations were far less than expected and that it was rare in non-familial cases.
High prevalence of PROP1 defects in Lithuania is due to 296delGA mutation, suggesting a founder effect.
A homozygous frameshift mutation of PROP1 (296delGA) was identified in siblings. Defects in PROP1 cause progressive deficiency of multiple pituitary hormones; PROP1 deficiency may present as isolated central hypothyroidism at a very young age
AES (show AES Proteins) binds to PROP1 and represses its expression; PROP1 mutation is a likely cause of combined pituitary hormone (show CGA Proteins) deficiency.
Data suggest that formation of a heterodimer between HESX1 (show HESX1 Proteins) and PROP1 allows HESX1 (show HESX1 Proteins) to become active, and that PROP1 then replaces HESX1 (show HESX1 Proteins) to advance to the middle stage of pituitary development.
Prop-1 participates in the regulation of FSHbeta gene
Prop-1 might be involved in development of gonadotropes and hormone production
Dimeric binding of PROP1 is able to recognize diverse palindromic TAAT sequences separated by 3 nucleotides and to exhibit its transcriptional activity.
The H173R mutation in PROP1 can be considered as a DNA marker for selecting individuals with superior growth traits, thereby contributing to research on breeding and genetics in the beef industry.
This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone.
, homeobox protein prophet of Pit-1
, pituitary specific homeodomain factor
, pituitary-specific homeodomain factor
, prophet of Pit-1
, PROP paired-like homeobox 1
, prophet of Pit1, paired-like homeodomain transcription factor
, paired like homeodomain factor 1
, prophet of Pit1 paired-like homeodomain transcription factor