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PRP8 Pre-MRNA Processing Factor 8 Homolog (S. Cerevisiae) (PRPF8) ELISA Kits

Pre-mRNA splicing occurs in 2 sequential transesterification steps. Additionally we are shipping PRPF8 Antibodies (20) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat PRPF8 PRPF8 287530  
Anti-Human PRPF8 PRPF8 10594 Q6P2Q9
Anti-Mouse PRPF8 PRPF8 192159 Q99PV0
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More ELISA Kits for PRPF8 Interaction Partners

Zebrafish PRP8 Pre-MRNA Processing Factor 8 Homolog (S. Cerevisiae) (PRPF8) interaction partners

  1. Within early haematopoiesis, myeloid differentiation is impaired, suggesting Prpf8 is required for haematopoietic development.

Human PRP8 Pre-MRNA Processing Factor 8 Homolog (S. Cerevisiae) (PRPF8) interaction partners

  1. Our findings exemplify the regulatory potential of changes in the core spliceosome machinery, which may be relevant to slow-onset human genetic diseases linked to PRPF8 deficiency

  2. Most importantly between Prp8 and nucleotides at the exon-intron junction.

  3. A mutation in a splicing factor (show SLU7 ELISA Kits) PRPF8 that causes retinitis pigmentosa has a transcriptome-wide effect on mRNA splicing.

  4. Data suggest Enterovirus 3DPol (RNA-dependent RNA polymerase) enters nucleus via nuclear localization signal, targets pre-mRNA processing factor 8 (Prp8) to block pre-mRNA splicing/mRNA synthesis, and shuts off cellular transcription/translation.

  5. In the cytoplasm, Prp8 forms a precursor complex with U5 snRNA

  6. these data show how a Ski2-like RNA helicase (show DDX46 ELISA Kits) Brr2 can be reversibly inhibited by a protein cofactor Prp8 that directly competes with RNA substrate binding.

  7. This is the first report of marked intrafamilial variability associated with mutations in the PRPF8 gene, including incomplete penetrance. PRPF8 mutations should be suspected in patients with autosomal dominant retinitis pigmentosa.

  8. RP-PRPF defects affect the stoichiometry of spliceosomal small nuclear RNAs. Depleting PRPF8 in human cell lines alters alternative splicing.

  9. Data screened retinitis pigmentosa patients for PRPF8 mutations and identified three new missense mutations, including the first documented mutation outside exon 42 and the first de novo mutation.

  10. Mutations in PRPC8 is associated with autosomal dominant retinitis pigmentosa

Mouse (Murine) PRP8 Pre-MRNA Processing Factor 8 Homolog (S. Cerevisiae) (PRPF8) interaction partners

  1. The mouse retinal pigment epithelium (RPE)is the primary cell affected by mutations in the RNA splicing factors (PRPF3 (show PRPF3 ELISA Kits), PRPF8, and PRPF31 (show PRPF31 ELISA Kits)), and these changes occur at an early age.

  2. found that PRP31 (show PRPF31 ELISA Kits) and PRPC8 as well as snRNAs are highly expressed in retinal cells

  3. The finding of similar degenerative changes in RPE cells of all three mouse models suggests that the retinal pigment epithelium may be the primary cell type affected in the RNA splicing factor (show SLU7 ELISA Kits) forms of retinitis pigmentosa.

PRPF8 Antigen Profile

Antigen Summary

Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.

Gene names and symbols associated with PRPF8

  • pre-mRNA processing factor 8 (Prpf8) antibody
  • pre-mRNA processing factor 8 (prpf8) antibody
  • PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) (PRPF8) antibody
  • pre-mRNA processing factor 8 (PRPF8) antibody
  • AU019467 antibody
  • D11Bwg0410e antibody
  • DBF3/PRP8 antibody
  • HPRP8 antibody
  • id:ibd1257 antibody
  • ik:tdsubc_2a9 antibody
  • im:7141966 antibody
  • prp-8 antibody
  • Prp8 antibody
  • PRPC8 antibody
  • RP13 antibody
  • Sfprp8l antibody
  • SNRNP220 antibody
  • tdsubc_2a9 antibody
  • wu:fb37c02 antibody
  • wu:fb73e06 antibody
  • xx:tdsubc_2a9 antibody
  • zgc:56504 antibody

Protein level used designations for PRPF8

PRP8 pre-mRNA processing factor 8 homolog , pre-mRNA-processing-splicing factor 8 , 220 kDa U5 snRNP-specific protein , PRP8 homolog , U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p , apoptosis-regulated protein 1 , apoptosis-regulated protein 2 , p220 , precursor mRNA processing protein , splicing factor Prp8

GENE ID SPECIES
287530 Rattus norvegicus
393951 Danio rerio
379945 Xenopus laevis
417559 Gallus gallus
480651 Canis lupus familiaris
507371 Bos taurus
10594 Homo sapiens
192159 Mus musculus
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