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PTEN Induced Putative Kinase 1 Proteins (PINK1)

PINK1 encodes a serine/threonine protein kinase that localizes to mitochondria. Additionally we are shipping PINK1 Antibodies (215) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PINK1 65018 Q9BXM7
PINK1 68943 Q99MQ3
Rat PINK1 PINK1 298575  
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Top PINK1 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$344.14
Details

PINK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
, ,

Top referenced PINK1 Proteins

  1. Human PINK1 Protein expressed in Escherichia coli (E. coli) - ABIN667580 : Valente, Salvi, Ialongo, Marongiu, Elia, Caputo, Romito, Albanese, Dallapiccola, Bentivoglio: PINK1 mutations are associated with sporadic early-onset parkinsonism. in Annals of neurology 2004 (PubMed)
    Show all 2 references for ABIN667580

More Proteins for PTEN Induced Putative Kinase 1 (PINK1) Interaction Partners

Fruit Fly (Drosophila melanogaster) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Clu (show CLU Proteins) directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.

  2. Human Mask homolog ANKHD1 (show ANKHD1 Proteins) may serve as a potential therapeutic target for treating Parkinson disease caused by pink1/parkin (show PARK2 Proteins) mutations.

  3. Various ways of stimulation of the ETC (genetic, pharmacologic and mechanical) (Figure 1) all improve a Pink1 fly model.

  4. These results indicate that the in vivo rescue is due to restoring CI activity rather than promoting mitophagy Our findings support the emerging view that PINK1 plays a role in regulating complex I activity separate from its role with Parkin (show PARK2 Proteins) in mitophagy

  5. MUL1 (show MUL1 Proteins) acts in parallel to the PINK1/parkin (show PARK2 Proteins) pathway on a shared target mitofusin (show MFN2 Proteins) to maintain mitochondrial integrity.

  6. PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila.

  7. PINK1 cooperates with Parkin to promote hnRNP-F/Glo ubiquitination and nRCC mRNA translation.

  8. results strongly circumscribe the possible mechanisms of PINK1 action in the mitochondrial life cycle

  9. PINK1 counteracts the neurotoxicity of PINK1 counteracts the neurotoxicity of mutant Htt (show HTT Proteins).

  10. Parkin (show PARK2 Proteins) phosphorylation by PINK1 drives Parkin (show PARK2 Proteins) E3 activity. endogenous PINK1 precisely controls Parkin (show PARK2 Proteins) activity to maintain the mitochondrial function in muscle tissue and the neuronal function in dopaminergic neurons.

Zebrafish PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Pink1-depleted zebrafish are the first vertebrate model of PINK1 deficiency with loss of dopaminergic neurons.

  2. Our findings suggest that a lack of pink1 in zebrafish alters many vital and critical pathways in addition to the HIF signaling pathway.

  3. Distinct groups of dopaminergic neurons are sensitive to targeted loss of Pink1 factor in a morphant fish model of toxin-induced Parkinson's disease.

  4. Morpholino-mediated loss of pink1 function in zebrafish profoundly affects the development of dopaminergic neurons in the ventral diencephalon and affects behaviour of the zebrafish larvae, namely their response to tactile stimuli and locomotor behavior.

Human PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Differential submitochondrial localization of PINK1 serves as a molecular switch for mediating two distinct mitochondrial signaling pathways in maintenance of mitochondrial homeostasis.

  2. Processing and shuttling of PINK1 through mitochondria is conformed to at least three possible functional microcompartments for PINK1 activity (I, cytosol; II, outer mitochondrial membrane; III, inside mitochondria).

  3. pathogenic PINK1 mutants which are not cleaved by PARL (show PARL Proteins) affect PINK1 kinase activity and the ability to induce PARK2 (show PARK2 Proteins)-mediated mitophagy.

  4. results indicate that PINK1 expression is positively regulated by NRF2 (show GABPA Proteins) and that the NRF2 (show GABPA Proteins)-PINK1 signaling axis is deeply involved in cell survival.

  5. High expression of PARK6 might lead to the occurrence of non-small-cell lung cancer.

  6. These results suggest that pyruvate is required for CCCP-induced PINK1/PARK2 (show PARK2 Proteins)-mediated mitophagy.

  7. PINK1-PARK2 (show PARK2 Proteins) pathway-mediated mitophagy plays a key regulatory role in CSE-induced mitochondrial ROS (show ROS1 Proteins) production and cellular senescence in human bronchial epithelial cells

  8. Rab8A (show RAB8A Proteins) GTPase (show RACGAP1 Proteins) Ser (show SIGLEC1 Proteins)(111) phosphorylation is not directly regulated by PINK1 in vitro and demonstrate in cells the time course of Ser (show SIGLEC1 Proteins)(111) phosphorylation of Rab8A (show RAB8A Proteins), 8B and 13 is markedly delayed compared to phosphorylation of Parkin (show PARK2 Proteins) at Ser (show SIGLEC1 Proteins)(65).

  9. mutant G309D PINK1 significantly reduced phosphorylation of GSK3beta at serine 9, suggesting that alterations in GSK3beta activity play an essential role in mutant G309D PINK1-induced tau phosphorylation at the PHF-1 (show PHF1 Proteins) site

  10. TGF-beta1 (show TGFB1 Proteins) induces lung epithelial cell mitochondrial ROS (show ROS1 Proteins) and depolarization and stabilizes the key mitophagy initiating protein, PINK1

Mouse (Murine) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. PINK1 deficiency causes defects in GFAP (show GFAP Proteins)-positive astrogliogenesis during brain development.

  2. The findings of this study show a CB1R (show CNR1 Proteins) dysfunction at corticostriatal synapses in PINK1(-/-), but not in PINK1(+/-) mice, and provide a mechanistic link to the distinct plasticity deficits observed in both genotypes.

  3. Loss of PINK1 inhibits Ca2+ efflux by NCLX and triggers mitochondrial depolarization.

  4. PINK1 gene knockout can protect neonatal mice from hypoxic-ischemic brain damage (HIBD).

  5. Loss of Pink1 reprograms glucose metabolism through HIF1alpha (show HIF1A Proteins), sustaining increased cell proliferation.

  6. findings support the notion that BAG2 (show BAG2 Proteins) is an upstream regulator of the PINK1/PARKIN (show PARK2 Proteins) signaling pathway.

  7. Interplay between E2F1 (show E2F1 Proteins), miR421 and Pink1 regulates mitochondrial morphology and cardiomyocyte death. Pink1 reduces mitochondrial fragmentation and protects cardiomyocyte from apoptosis.

  8. data suggest that Parkin (show PARK2 Proteins) recruitment to depolarized cardiac mitochondria and subsequent activation of mitophagy is independent of PINK1.

  9. The PINK1-Parkin (show PARK2 Proteins) pathway is activated in response to metabolic stress

  10. TGF-beta1 (show TGFB1 Proteins) induces lung epithelial cell mitochondrial ROS (show ROS1 Proteins) and depolarization and stabilizes the key mitophagy initiating protein, PINK1

PINK1 Protein Profile

Protein Summary

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Gene names and symbols associated with PINK1

  • PTEN-induced putative kinase 1 (Pink1)
  • PTEN induced putative kinase 1 (PINK1)
  • PTEN induced putative kinase 1 (pink1)
  • PTEN induced putative kinase 1 (Pink1)
  • 1190006F07Rik protein
  • AU042772 protein
  • AW557854 protein
  • BEST:GH23468 protein
  • BRPK protein
  • CG4523 protein
  • Dmel\\CG4523 protein
  • dPink1 protein
  • mFLJ00387 protein
  • PARK6 protein
  • PINK protein
  • pink1 protein
  • wu:fc39e12 protein
  • zgc:101729 protein

Protein level used designations for PINK1

CG4523-PA , CG4523-PB , CG4523-PC , CG4523-PD , CG4523-PE , CG4523-PF , CG4523-PG , CG4523-PH , PTEN induced putative kinase 1 , PTEN-Induced kinase 1 , Pink1-PA , Pink1-PB , Pink1-PC , Pink1-PD , Pink1-PE , Pink1-PF , Pink1-PG , Pink1-PH , PTEN-induced putative kinase 1 , serine/threonine-protein kinase PINK1, mitochondrial , serine/threonine-protein kinase PINK1, mitochondrial-like , PTEN-induced putative kinase protein 1 , protein kinase BRPK

GENE ID SPECIES
31607 Drosophila melanogaster
425370 Gallus gallus
494085 Danio rerio
510683 Bos taurus
706037 Macaca mulatta
749028 Pan troglodytes
100027082 Monodelphis domestica
100412264 Callithrix jacchus
100443445 Pongo abelii
100465867 Ailuropoda melanoleuca
65018 Homo sapiens
68943 Mus musculus
298575 Rattus norvegicus
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