anti-PTEN Induced Putative Kinase 1 (PINK1) Antibodies

PINK1 encodes a serine/threonine protein kinase that localizes to mitochondria. Additionally we are shipping PINK1 Proteins (13) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PINK1 65018 Q9BXM7
PINK1 68943 Q99MQ3
PINK1 298575  
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Top anti-PINK1 Antibodies at antibodies-online.com

Showing 10 out of 237 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Rat Goat Un-conjugated ELISA, WB ABIN334460 (1µg/ml) staining of Rat Testis lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of anti-PARK6 Pab in mouse kidney tissue lysate. PARK6 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Park6 (PINK1) C-term (ABIN652208) in mouse kidney tissue lysates (35 µg/lane). Park6 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 0.1 mL Log in to see 7 to 9 Days
$381.94
Details
Human Mouse Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: PINK1 Antibody (8E10.1D6) [NBP2-36488] - Whole cell protein from HeLa cells treated with or without valinomycin (1 uM for 24h) as indicated was separated by SDS-PAGE on a 7.5% polyacrylamide gel. Protein was transferred to PVDF membrane and probed with 2 ug/ml anti-PINK1 in 1% BSA and detected with an HRP-conjugated anti-mouse secondary antibody using chemiluminescence. PINK1 is seen to be upregulated at approximately 60 kDa (arrowhead) with treament. Western Blot: PINK1 Antibody (8E10.1D6) [NBP2-36488] - WB analysis of (A) 13kDa Partial Recombinant Human PINK-1 protein and (B) Human Liver lysate using PINK1 antibody clone 8E10.1D6 at 3ug/ml concentration. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated SimWes, WB Western blot of C-terminally V5His-tagged human Pink1 or N-terminally myc-tagged human Pink1 expressed in HEK293T cells.  ABIN152067 detects transfected Pink1 protein. Simple Western: PINK1 Antibody [ABIN152067] - Simple Western lane view shows a specific band for PINK1 in 1.0 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.1 mg Log in to see 7 to 9 Days
$317.63
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, IHC (p), IP, WB Immunocytochemistry/Immunofluorescence: PINK1 Antibody [BC100-494] - Immunocytochemistry of PINK1 antibody (BC100-494 Lot G). HeLa cells were treated with valinomycin (1 uM for 24h) prior to being fixed in 10% buffered formalin for 10 min and permeabilized in 0.1% Triton X-100 in PBS for 10 min. Cells were incubated with BC100-494 at 20 ug/ml for 1h at room temperature, washed 3x in PBS and incubated with Alexa-Fluor488 anti-rabbit secondary antibody. PINK1 (Green) was detected at the mitochondria. Tubulin (Red) was detected using an anti-tubulin antibody with an anti-mouse DyLight 550 secondary antibody. DNA (Blue) was counterstained with DAPI. Note: mitochondria staining might not be easily observed without treatment with valinomycin or CCCP. Western Blot: PINK1 Antibody [BC100-494] - Whole cell protein from HeLa cells treated without or with valinomycin (1 uM for 24h) as indicated were separated by SDS-PAGE on a 7.5% polyacrylamide gel. Protein was transferred to PVDF membrane and probed with 1.0 ug/ml BC100-494 in 1% BSA and detected with an HRP-conjugated anti-rabbit secondary antibody using chemiluminescence. PINK1 was detected at approximately 60 kDa in the treated sample(arrowhead). 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB The anti-PINK1 C-term Pab (ABIN1882117) is used in Western blot to detect PINK1 in mouse heart tissue lysate. The anti-PINK1 C-term Pab (ABIN1882117) is used in Western blot to detect PINK1 in mouse heart tissue lysate. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details

PINK1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-PINK1 Antibodies

  1. Human Polyclonal PINK1 Primary Antibody for ELISA, ICC - ABIN249446 : Weihofen, Ostaszewski, Minami, Selkoe: Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. in Human molecular genetics 2008 (PubMed)
    Show all 85 references for 249446

  2. Human Polyclonal PINK1 Primary Antibody for WB - ABIN151937 : Meijer, Karimi-Busheri, Huang, Weinfeld, Young: Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for 151937

  3. Human Polyclonal PINK1 Primary Antibody for WB - ABIN1882117 : Rogaeva, Johnson, Lang, Gulick, Gwinn-Hardy, Kawarai, Sato, Morgan, Werner, Nussbaum, Petit, Okun, McInerney, Mandel, Groen, Fernandez, Postuma, Foote: Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. in Archives of neurology 2004 (PubMed)
    Show all 4 references for 1882117

  4. Human Polyclonal PINK1 Primary Antibody for SimWes, WB - ABIN152067 : Xiong, Wang, Chen, Choo, Ma, Tang, Xia, Jiang, Ronai, Zhuang, Zhang: Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. in The Journal of clinical investigation 2009 (PubMed)
    Show all 3 references for 152067

  5. Human Polyclonal PINK1 Primary Antibody for EIA, IHC (p) - ABIN358994 : Hatano, Li, Sato, Asakawa, Yamamura, Tomiyama, Yoshino, Asahina, Kobayashi, Hassin-Baer, Lu, Ng, Rosales, Shimizu, Toda, Mizuno, Hattori: Novel PINK1 mutations in early-onset parkinsonism. in Annals of neurology 2004 (PubMed)
    Show all 2 references for 358994

  6. Human Monoclonal PINK1 Primary Antibody for ICC, IF - ABIN4345677 : Ko, Park, Park, Koh: PPAR-γ activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction. in Toxicology letters 2016 (PubMed)

  7. Human Polyclonal PINK1 Primary Antibody for WB - ABIN652208 : Berthier, Jiménez-Sáinz, Pulido: PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)

  8. Rat (Rattus) Polyclonal PINK1 Primary Antibody for ELISA, WB - ABIN334460 : Chishti, Bohlega, Ahmed, Loualich, Carroll, Sato, St George-Hyslop, Westaway, Rogaeva: T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease. in Archives of neurology 2006 (PubMed)

More Antibodies against PINK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin (show PARK2 Antibodies) flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  2. autophosphorylation of PINK1 is essential for the mitochondrial translocation of Parkin (show PARK2 Antibodies) and for subsequent phosphorylation and activation of Parkin (show PARK2 Antibodies).

  3. A pink1 genomic knock-in allele was generated to monitor the dynamic expression pattern of PINK1. The spatiotemporal expression pattern of PINK1 correlates with the cell-type specific mitochondrial clearance or persistence. PINK1 and PARKIN (show PARK2 Antibodies) function epistatically to mediate timely specific mitophagy during Drosophila midgut metamorphosis.

  4. Our data indicate that PINK1 and Parkin (show PARK2 Antibodies) play an important role in FUS (show FUS Antibodies)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (show FUS Antibodies) proteinopathy and PINK1/Parkin (show PARK2 Antibodies) genes, providing new insights into the pathogenesis of FUS (show FUS Antibodies) proteinopathy.

  5. we show that overexpression of Drosophila Clu (show CLU Antibodies) complements PINK1, but not parkin (show PARK2 Antibodies), mutant muscles. Thus, Clu (show CLU Antibodies) is essential for mitochondrial homeostasis and functions in concert with Parkin (show PARK2 Antibodies) and VCP (show vcp Antibodies) for Marf (show MFN2 Antibodies) degradation to promote damaged mitochondrial clearance.

  6. In addition, a PINK1 mutant, which induced mitochondrial enlargement and had been considered as a Drosophila model of Parkinson's disease (PD), caused fly muscle defects, and the loss of vimar could rescue these defects. Furthermore, we found that the mammalian homolog of Vimar, RAP1GDS1 (show RAP1GDS1 Antibodies), played a similar role in regulating mitochondrial morphology, suggesting a functional conservation of this GEF (show SLC2A4RG Antibodies) member.

  7. Buffy has a role enhancing the loss of parkin (show PARK2 Antibodies) and suppressing the loss of Pink1 phenotypes in Drosophila

  8. PINK1-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  9. Clu (show CLU Antibodies) directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.

  10. Human Mask homolog ANKHD1 (show ANKHD1 Antibodies) may serve as a potential therapeutic target for treating Parkinson disease caused by pink1/parkin (show PARK2 Antibodies) mutations.

Zebrafish PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Pink1-depleted zebrafish are the first vertebrate model of PINK1 deficiency with loss of dopaminergic neurons.

  2. Our findings suggest that a lack of pink1 in zebrafish alters many vital and critical pathways in addition to the HIF signaling pathway.

  3. Distinct groups of dopaminergic neurons are sensitive to targeted loss of Pink1 factor in a morphant fish model of toxin-induced Parkinson's disease.

  4. Morpholino-mediated loss of pink1 function in zebrafish profoundly affects the development of dopaminergic neurons in the ventral diencephalon and affects behaviour of the zebrafish larvae, namely their response to tactile stimuli and locomotor behavior.

Human PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Adipogenic process can be dissected into 3 stages according to the participation of PARL (show PARL Antibodies)-PINK1-Parkin (show PARK2 Antibodies) system. Findings reveal the sequential adipogenic events directed by PARL (show PARL Antibodies)-PINK1-Parkin (show PARK2 Antibodies) system, add more evidence supporting the convergence of pathogenesis leading to neurodegenerative and metabolic disease

  2. PKA-mediated phosphorylation of MIC60 negatively regulates mitochondrial clearance that is initiated by PINK1 and Parkin (show PARK2 Antibodies).

  3. We report that loss of PINK1 contributes to the Warburg effect through ROS (show ROS1 Antibodies)-dependent stabilization of hypoxia-inducible factor-1A and reduced pyruvate kinase muscle isozyme 2 activity which highlight the importance of PINK1 and reactive oxygen species balance in normal and tumor cells.

  4. PINK1 disease mutants failed to recruit synphilin-1 (show SNCAIP Antibodies) and did not activate mitophagy, indicating that PINK1-synphilin-1 (show SNCAIP Antibodies)-SIAH-1 (show SIAH1 Antibodies) represents a new parkin (show PARK2 Antibodies)-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.

  5. PINK1 p.G411S is a rare genetic risk factor with a relatively large effect size conferred by a partial dominant-negative function phenotype.

  6. In summary, our results demonstrate that PINK1 promoted hepatic IR via JNK (show MAPK8 Antibodies) and ERK (show EPHB2 Antibodies) pathway in PA treated HepG2 cells, implying a novel molecular target for the therapy of diabetes.

  7. the results suggest that BNIP3 (show BNIP3 Antibodies) plays a vital role in regulating PINK1 mitochondrial outer membrane localization, the proteolytic process of PINK1 and PINK1/parkin (show PARK2 Antibodies)-mediated mitophagy under physiological conditions.

  8. PINK1 interferes with selective mitochondrial fission and mitophagy.

  9. findings suggest that PINK1 and PARKIN (show PARK2 Antibodies) play critical roles in selective cell death in which damaged mitochondria are retained, independent of mitochondrial autophagy.

  10. findings underscore the importance of a mitophagy regulatory network of ATM (show ATM Antibodies) and PINK1/Parkin (show PARK2 Antibodies) and elucidate a novel mechanism by which ATM (show ATM Antibodies) influences spermidine-induced mitophagy

Mouse (Murine) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. study identifies a new role of Dual-AKAP1 (show AKAP1 Antibodies) in regulating mitochondrial trafficking through Miro-2 (show RHOT2 Antibodies), and supports a model in which PINK1 and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity

  2. Study showed that apoptosis is an important form of cellular degeneration in lipopolysaccharide (LPS (show TLR4 Antibodies)-sensitized hypoxic-ischemic (HI) injury in the immature brain. Loss of PINK1 can protect the immature brain against cell apoptosis induced by LPS (show TLR4 Antibodies)-sensitized HI injury. Moreover, alpha-Syn plays a neuroprotective role in LPS (show TLR4 Antibodies)-sensitized HI brain damage in PINK1-knockout neonatal mice

  3. the results suggest that BNIP3 (show BNIP3 Antibodies) plays a vital role in regulating PINK1 mitochondrial outer membrane localization, the proteolytic process of PINK1 and PINK1/parkin (show PARK2 Antibodies)-mediated mitophagy under physiological conditions.

  4. lack of PINK1 causes increased excitatory transmission and neurotransmitter release in the hippocampus, which might lead to the cognitive decline often observed in Parkinson's disease

  5. The identification of PINK1 and Parkin (show PARK2 Antibodies) as suppressors of an immune-response-eliciting pathway provoked by inflammation suggests new insights into Parkinson's disease pathology.

  6. PINK1 deficiency causes defects in GFAP (show GFAP Antibodies)-positive astrogliogenesis during brain development.

  7. The findings of this study show a CB1R (show CNR1 Antibodies) dysfunction at corticostriatal synapses in PINK1(-/-), but not in PINK1(+/-) mice, and provide a mechanistic link to the distinct plasticity deficits observed in both genotypes.

  8. Loss of PINK1 inhibits Ca2 (show CA2 Antibodies)+ efflux by NCLX (show SLC24A6 Antibodies) and triggers mitochondrial depolarization.

  9. PINK1 gene knockout can protect neonatal mice from hypoxic-ischemic brain damage (HIBD).

  10. Loss of Pink1 reprograms glucose metabolism through HIF1alpha (show HIF1A Antibodies), sustaining increased cell proliferation.

PINK1 Antigen Profile

Protein Summary

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Gene names and symbols associated with PINK1

  • PTEN-induced putative kinase 1 (Pink1) antibody
  • PTEN induced putative kinase 1 (PINK1) antibody
  • PTEN induced putative kinase 1 (pink1) antibody
  • PTEN induced putative kinase 1 (Pink1) antibody
  • 1190006F07Rik antibody
  • AU042772 antibody
  • AW557854 antibody
  • BEST:GH23468 antibody
  • BRPK antibody
  • CG4523 antibody
  • Dmel\\CG4523 antibody
  • dPink1 antibody
  • mFLJ00387 antibody
  • PARK6 antibody
  • PINK antibody
  • pink1 antibody
  • wu:fc39e12 antibody
  • zgc:101729 antibody

Protein level used designations for PINK1

CG4523-PA , CG4523-PB , CG4523-PC , CG4523-PD , CG4523-PE , CG4523-PF , CG4523-PG , CG4523-PH , PTEN induced putative kinase 1 , PTEN-Induced kinase 1 , Pink1-PA , Pink1-PB , Pink1-PC , Pink1-PD , Pink1-PE , Pink1-PF , Pink1-PG , Pink1-PH , PTEN-induced putative kinase 1 , serine/threonine-protein kinase PINK1, mitochondrial , serine/threonine-protein kinase PINK1, mitochondrial-like , PTEN-induced putative kinase protein 1 , protein kinase BRPK

GENE ID SPECIES
31607 Drosophila melanogaster
425370 Gallus gallus
494085 Danio rerio
510683 Bos taurus
706037 Macaca mulatta
749028 Pan troglodytes
100027082 Monodelphis domestica
100412264 Callithrix jacchus
100443445 Pongo abelii
100465867 Ailuropoda melanoleuca
65018 Homo sapiens
68943 Mus musculus
298575 Rattus norvegicus
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