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PTK2 encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Additionally we are shipping FAK Kits (29) and FAK Proteins (12) and many more products for this protein.
Showing 10 out of 689 products:
Chicken Monoclonal FAK Primary Antibody for BI, IP - ABIN967736
Clancy, Rediske, Tang, Nijher, Frenkel, Philips, Abramson: Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. in The Journal of clinical investigation 1997
Show all 7 references for ABIN967736
Human Polyclonal FAK Primary Antibody for EIA, WB - ABIN453801
Calalb, Polte, Hanks: Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. in Molecular and cellular biology 1995
Show all 3 references for ABIN453801
Human Polyclonal FAK Primary Antibody for IHC, ELISA - ABIN1532611
Lee, Strunk, Spritz: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. in Oncogene 1993
Human Polyclonal FAK Primary Antibody for FACS, IF - ABIN652554
Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression. in The Journal of biological chemistry 2012
Human Polyclonal FAK Primary Antibody for IF, IHC - ABIN1532612
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Upregulated expression of FAK is associated with hepatocellular carcinoma.
ITGB4 (show ITGB4 Antibodies) is overexpressed in hepatocellular carcinoma tissues and promotes metastases of HCC (show FAM126A Antibodies) by conferring anchorage independence through EGFR (show EGFR Antibodies)-dependent FAK-AKT (show AKT1 Antibodies) activation.
Data show that rab5 (show RAB5A Antibodies) GTP-Binding Protein (Rab5a (show RAB5A Antibodies)) is overexpressed in human hepatocellular carcinoma (HCC (show FAM126A Antibodies)) and contributes to cancer cell proliferation and invasion through regulation of FAK and AKT (show AKT1 Antibodies) signaling.
LEFTY2 (show LEFTY2 Antibodies) down-regulates MKi67 (show MKI67 Antibodies) expression and FAK activity, up-regulates miR (show MLXIP Antibodies)-200a and E-cadherin (show CDH1 Antibodies), and is thus a powerful negative regulator of endometrial cell proliferation and migration.
Calcium lactate (2.5 mM), alone and in combination with 5-FU, exerted antitumor activity against both anchored and unanchored colorectal cells via calcium-mediated FAK proteolysis and inhibition of EMT (show ITK Antibodies) markers, such as vimentin (show VIM Antibodies) and SNAIL (show SNAI1 Antibodies).
From our data we conclude that targeting of CXCR4 (show CXCR4 Antibodies) and FAK may overcome ABCB1 (show ABCB1 Antibodies) and ABCC1 (show ABCC1 Antibodies)-dependent doxorubicin resistance in non-small cell lung carcinoma cells
Periostin (show POSTN Antibodies) expression in human periodontal ligament fibroblasts promotes the migration of human mesenchymal stem cells through the alphavbeta3 integrin/FAK/PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway in vitro.
High FAK expression is associated with cervical cancer.
Studies propose that localization of FAK Y407, rather than FAK expression and overall FAK Y407 phosphorylation levels, is crucial for the control of cell motility of triple-negative breast cancer (TNBC) cell lines and suggest that subcellular localization, next to expression and activity levels, are important for understanding TNBC progression.
FAK activation is necessary for the promotion of osteogenesis induced by extracorporeal shockwave.
FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.
FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.
work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development
These data suggest an important role for the FERM domain in the activation of FAK.
FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (show BDNF Antibodies), while phosphorylation at Y925 controls the rate of point contact turnover.
Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.
FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.
FAK promotes nascent integrin adhesions (NA) assembly and timely turnover to couple lamellipodial protrusion to adhesions for efficient advance of the leading edge. Phosphorylation on Y397 of FAK promotes dense NA formation but is dispensable for transient NA stabilization and leading edge advance.
this manuscript shows that endothelial cell FAK activity induces VCAM-1 (show VCAM1 Antibodies) expression and contributes to atherosclerosis
Data show that the essential oil (EO) decreased focal adhesion and invadopodia formation which was accompanied by a drastic downregulation of focal adhesion kinase (FAK) and proto-oncogene protein Src.
results suggest that LPS (show TLR4 Antibodies)-stimulated macrophage mediators attenuate both FAK and Src (show SRC Antibodies) activations in osteoblast, suggesting a novel role for TNFalpha (show TNF Antibodies) on osteoblast performance
Report phosphorylation sites in focal adhesion kinase and putative new binding partners.
data indicate that PTPalpha (show PTPRA Antibodies) and FAK, which are enriched in FAs (show FAS Antibodies), interact with IP3R1 (show ITPR1 Antibodies) at adjacent ER sites to spatially sequester IL-1 (show IL1A Antibodies)-induced Ca(2 (show CA2 Antibodies)+) signalling
FAK-regulated signalling module PDK1 (show PDPK1 Antibodies)-Akt (show AKT1 Antibodies)-p70S6K (show RPS6KB1 Antibodies) that controls Src's intracellular trafficking operates at Src (show SRC Antibodies)-containing autophagosomes.
Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes.
FAK deletion correlates with increased phosphorylation of Tks-5 (show SH3PXD2A Antibodies) (tyrosine kinase substrate (show IRS2 Antibodies) with five SH3 domain (show ITSN1 Antibodies)) and reactive oxygen species production.
RhoA (show RHOA Antibodies) and membrane fluidity mediates the spatially polarized Src (show SRC Antibodies)/FAK activation in response to shear stress.
XIAP (show XIAP Antibodies) plays an essential role in shear stress-stimulated FAK phosphorylation.
mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C (show PKC Antibodies)
These results suggest that TGF-beta1 (show TGFB1 Antibodies)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (show SRC Antibodies)-dependent and -independent pathways.
Results suggest focal adhesion kinase is involved in thrombospondin-1 (show THBS1 Antibodies)-induced vascular smooth muscle cell migration.
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
, FAK-related non-kinase polypeptide
, PTK2 protein tyrosine kinase 2
, focal adhesion kinase 1
, focal adhesion kinase-related nonkinase
, protein phosphatase 1 regulatory subunit 71
, protein phosphatase 1, regulatory subunit 71
, protein-tyrosine kinase 2
, focal adhesion kinase pp125FAK
, focal ashension kinase 1
, focal adhesion kinase