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anti-PTK2 Protein tyrosine Kinase 2 (PTK2) Antibodies

PTK2 encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Additionally we are shipping FAK Kits (28) and FAK Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTK2 5747 Q05397
PTK2 25614 O35346
PTK2 14083 P34152
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Top anti-FAK Antibodies at antibodies-online.com

Showing 10 out of 649 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells treated with Ca2+ 40nM 30', using FAK (Phospho-Tyr397) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using FAK (Phospho-Tyr397) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain, using FAK (Phospho-Ser910) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using FAK (Phospho-Ser910) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from 293 cells treated with EGF 200ng/ml 30', using FAK (Phospho-Tyr397) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2 cells treated with PMA 125ng/ml 20', using FAK (Phospho-Ser843) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from MCF-7/HuvEc cells, using FAK (Ab-843) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using FAK (Ab-843) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using FAK (Ab-577) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from HepG2/HT-29 cells, using FAK (Ab-397) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using FAK (Ab-397) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of PTK2 (arrow) using rabbit polyclonal PTK2 Antibody (C-term) (ABIN652554). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PTK2 gene (Lane 2). Formalin-fixed and paraffin-embedded human brain tissue reacted with PTK2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PTK2 (arrow) using rabbit polyclonal PTK2 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PTK2 gene (Lane 2). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Mouse Un-conjugated BI, IP, IHC, WB Western blot analysis of FAK on a A431 cell lysate (Human epithelial carcinoma, ATCC CRL-1555). Lane 1: 2 µg/ml, lane 2: 1 µg/ml, lane 3: 0.5 µg/ml of the mouse anti- FAK antibody. Immunofluorescent staining of U2OS (ATCC HTB-96) cells. Cells were seeded in a 96-well imaging plate at ~ 10,000 cells per well. After overnight incubation, cells were stained using the alcohol perm protocol and the anti-FAK antibody. The second step reagent was FITC goat anti-mouse Ig. Images were taken on a BD Pathway™ 855 bioimaging system using a 20x objective. This antibody also stained A549 (ATCC CCL-185) and HeLa (ATCC CCL-2) cells and worked with both the Triton™ X-100 and alcohol perm protocols. 50 μg Log in to see 5 to 6 Days
$205.42
Details

PTK2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FAK Antibodies

  1. Chicken Monoclonal FAK Primary Antibody for BI, IP - ABIN967736 : Clancy, Rediske, Tang, Nijher, Frenkel, Philips, Abramson: Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. in The Journal of clinical investigation 1997 (PubMed)
    Show all 7 references for ABIN967736

  2. Human Polyclonal FAK Primary Antibody for EIA, WB - ABIN453801 : Calalb, Polte, Hanks: Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. in Molecular and cellular biology 1995 (PubMed)
    Show all 3 references for ABIN453801

  3. Human Polyclonal FAK Primary Antibody for IHC, ELISA - ABIN1533049 : Lee, Strunk, Spritz: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. in Oncogene 1993 (PubMed)

  4. Human Polyclonal FAK Primary Antibody for FACS, IF - ABIN652554 : Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression. in The Journal of biological chemistry 2012 (PubMed)

  5. Human Polyclonal FAK Primary Antibody for IF, IHC - ABIN1532612 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006 (PubMed)

More Antibodies against FAK Interaction Partners

Human PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. CEP-37440 decreased the cell proliferation of FC-IBC02, SUM190, and KPL4 by blocking the autophosphorylation kinase activity of FAK1 (Tyr (show TYR Antibodies) 397).

  2. Bit1 (show PTRH2 Antibodies) may be an important regulator in cell growth, apoptosis, migration and invasion of esophageal squamous cell carcinoma via targeting FAK-paxillin (show PXN Antibodies) pathway.

  3. In human colon cancer cells, Akt1 (show AKT1 Antibodies) binds focal adhesion kinase via the Akt1 kinase (show AKT1 Antibodies) domain independently of the pleckstrin (show PLEK Antibodies) homology domain

  4. FAK enhances glycolysis and decreases mitochondrial respiration and increases key glycolytic proteins. Active/tyrosine-phosphorylated FAK directly binds to PKM2 and promotes PKM2-mediated glycolysis.

  5. Our findings suggest that the targets of FAK play a key role in metastasis

  6. Data suggest that, in colonic/prostatic neoplasm cells, increased expression of NDRG1 decreases activating phosphorylation of FAK and paxillin; silencing/inhibition of NDRG1 results in opposite effect and inhibits neoplasm cell migration/adhesion.

  7. Collectively, our data demonstrate that DCMF induces cell migration and promotes wound healing through activation of Src (show SRC Antibodies)/FAK, ERK (show EPHB2 Antibodies), AKT (show AKT1 Antibodies), and p38 MAPK (show MAPK14 Antibodies) signaling.

  8. These results suggest that ITCs could be potential agents for the prevention of C6 glioma cell migration and invasion by decreasing FAK/JNK (show MAPK8 Antibodies)-mediated MMP-9 (show MMP9 Antibodies) expression

  9. In clinical samples of hepatocellular carcinom (HCC (show FAM126A Antibodies)), miR (show MLXIP Antibodies)-379-5p negatively correlated with FAK, which was up-regulated in HCC (show FAM126A Antibodies).

  10. Combining erlotinib with FAK inhibitor was also potent in vivo as evidenced by reduced tumor growth in the A549 mouse xenograft model.

Xenopus laevis PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.

  2. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.

  3. work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development

  4. These data suggest an important role for the FERM domain in the activation of FAK.

  5. FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (show BDNF Antibodies), while phosphorylation at Y925 controls the rate of point contact turnover.

  6. Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.

  7. FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.

Mouse (Murine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. results suggest that LPS (show TLR4 Antibodies)-stimulated macrophage mediators attenuate both FAK and Src (show SRC Antibodies) activations in osteoblast, suggesting a novel role for TNFalpha (show TNF Antibodies) on osteoblast performance

  2. Report phosphorylation sites in focal adhesion kinase and putative new binding partners.

  3. data indicate that PTPalpha (show PTPRA Antibodies) and FAK, which are enriched in FAs (show FAS Antibodies), interact with IP3R1 (show ITPR1 Antibodies) at adjacent ER sites to spatially sequester IL-1 (show IL1A Antibodies)-induced Ca(2 (show CA2 Antibodies)+) signalling

  4. FAK-regulated signalling module PDK1 (show PDPK1 Antibodies)-Akt (show AKT1 Antibodies)-p70S6K (show RPS6KB1 Antibodies) that controls Src's intracellular trafficking operates at Src (show SRC Antibodies)-containing autophagosomes.

  5. Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes.

  6. FAK deletion correlates with increased phosphorylation of Tks-5 (show SH3PXD2A Antibodies) (tyrosine kinase substrate (show IRS2 Antibodies) with five SH3 domain (show ITSN1 Antibodies)) and reactive oxygen species production.

  7. Par4 (show F2RL3 Antibodies), CEBPB (show CEBPB Antibodies) and FAK form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT (show ITK Antibodies) and self-renewal

  8. LPS (show TLR4 Antibodies)-induced increases in intestinal TJP and intestinal inflammation were regulated by TLR4 (show TLR4 Antibodies)-dependent activation of the FAK/MyD88 (show MYD88 Antibodies)/IL-1R-associated kinase 4 signaling pathway.

  9. Inactivation of the FAK signaling pathway by either genetic or pharmacologic methods significantly sensitizes both murine and human PTEN (show PTEN Antibodies)-null T-ALL cells to PI3K/AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) inhibition when cultured in vitro on feeder layer cells or a matrix and in vivo

  10. These data indicate that FAK might exaggerate NMDAR (show GRIN1 Antibodies)-mediated synaptic transmission in the spinal dorsal horn to sensitize nociceptive behaviors.

Cow (Bovine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. RhoA (show RHOA Antibodies) and membrane fluidity mediates the spatially polarized Src (show SRC Antibodies)/FAK activation in response to shear stress.

  2. XIAP (show XIAP Antibodies) plays an essential role in shear stress-stimulated FAK phosphorylation.

  3. mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C (show PKC Antibodies)

  4. These results suggest that TGF-beta1 (show TGFB1 Antibodies)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (show SRC Antibodies)-dependent and -independent pathways.

  5. Results suggest focal adhesion kinase is involved in thrombospondin-1 (show THBS1 Antibodies)-induced vascular smooth muscle cell migration.

FAK (PTK2) Antigen Profile

Protein Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Gene names and symbols associated with PTK2

  • PTK2 protein tyrosine kinase 2 (PTK2) antibody
  • protein tyrosine kinase 2 (PTK2) antibody
  • protein tyrosine kinase 2 (Ptk2) antibody
  • protein tyrosine kinase 2 (ptk2) antibody
  • PTK2 protein tyrosine kinase 2 (Ptk2) antibody
  • Fadk antibody
  • FAK antibody
  • FAK1 antibody
  • FRNK antibody
  • mKIAA4203 antibody
  • p125FAK antibody
  • pp125FAK antibody
  • PPP1R71 antibody

Protein level used designations for PTK2

FADK 1 , FAK-related non-kinase polypeptide , PTK2 protein tyrosine kinase 2 , focal adhesion kinase 1 , focal adhesion kinase-related nonkinase , protein phosphatase 1 regulatory subunit 71 , protein phosphatase 1, regulatory subunit 71 , pp125FAK , protein-tyrosine kinase 2 , focal adhesion kinase pp125FAK , focal ashension kinase 1 , p41/p43FRNK , focal adhesion kinase

GENE ID SPECIES
100058245 Equus caballus
5747 Homo sapiens
25614 Rattus norvegicus
399286 Xenopus laevis
14083 Mus musculus
396416 Gallus gallus
475108 Canis lupus familiaris
506270 Bos taurus
Selected quality suppliers for anti-FAK (PTK2) Antibodies
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