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anti-PTK2 Protein tyrosine Kinase 2 (PTK2) Antibodies

PTK2 encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Additionally we are shipping FAK Kits (29) and FAK Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTK2 5747 Q05397
PTK2 25614 O35346
PTK2 14083 P34152
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Top anti-FAK Antibodies at antibodies-online.com

Showing 10 out of 689 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain, using FAK (Phospho-Ser910) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using FAK (Phospho-Ser910) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2 cells treated with PMA 125ng/ml 20', using FAK (Phospho-Ser843) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells treated with Ca2+ 40nM 30', using FAK (Phospho-Tyr397) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using FAK (Phospho-Tyr397) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from 293 cells treated with EGF 200ng/ml 30', using FAK (Phospho-Tyr397) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from MCF-7/HuvEc cells, using FAK (Ab-843) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using FAK (Ab-843) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from HepG2/HT-29 cells, using FAK (Ab-397) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using FAK (Ab-397) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using FAK (Ab-910) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of PTK2 (arrow) using rabbit polyclonal PTK2 Antibody (C-term) (ABIN652554). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PTK2 gene (Lane 2). Formalin-fixed and paraffin-embedded human brain tissue reacted with PTK2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PTK2 (arrow) using rabbit polyclonal PTK2 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PTK2 gene (Lane 2). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Mouse Un-conjugated BI, IP, IHC, WB Western blot analysis of FAK on a A431 cell lysate (Human epithelial carcinoma, ATCC CRL-1555). Lane 1: 2 µg/ml, lane 2: 1 µg/ml, lane 3: 0.5 µg/ml of the mouse anti- FAK antibody. Immunofluorescent staining of U2OS (ATCC HTB-96) cells. Cells were seeded in a 96-well imaging plate at ~ 10,000 cells per well. After overnight incubation, cells were stained using the alcohol perm protocol and the anti-FAK antibody. The second step reagent was FITC goat anti-mouse Ig. Images were taken on a BD Pathway™ 855 bioimaging system using a 20x objective. This antibody also stained A549 (ATCC CCL-185) and HeLa (ATCC CCL-2) cells and worked with both the Triton™ X-100 and alcohol perm protocols. 50 μg Log in to see 5 to 6 Days
$205.42
Details

PTK2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FAK Antibodies

  1. Chicken Monoclonal FAK Primary Antibody for BI, IP - ABIN967736 : Clancy, Rediske, Tang, Nijher, Frenkel, Philips, Abramson: Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. in The Journal of clinical investigation 1997 (PubMed)
    Show all 7 references for ABIN967736

  2. Human Polyclonal FAK Primary Antibody for EIA, WB - ABIN453801 : Calalb, Polte, Hanks: Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. in Molecular and cellular biology 1995 (PubMed)
    Show all 3 references for ABIN453801

  3. Human Polyclonal FAK Primary Antibody for IHC, ELISA - ABIN1532611 : Lee, Strunk, Spritz: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. in Oncogene 1993 (PubMed)

  4. Human Polyclonal FAK Primary Antibody for FACS, IF - ABIN652554 : Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression. in The Journal of biological chemistry 2012 (PubMed)

  5. Human Polyclonal FAK Primary Antibody for IF, IHC - ABIN1532612 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006 (PubMed)

More Antibodies against FAK Interaction Partners

Human PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. Upregulated expression of FAK is associated with hepatocellular carcinoma.

  2. ITGB4 (show ITGB4 Antibodies) is overexpressed in hepatocellular carcinoma tissues and promotes metastases of HCC (show FAM126A Antibodies) by conferring anchorage independence through EGFR (show EGFR Antibodies)-dependent FAK-AKT (show AKT1 Antibodies) activation.

  3. Data show that rab5 (show RAB5A Antibodies) GTP-Binding Protein (Rab5a (show RAB5A Antibodies)) is overexpressed in human hepatocellular carcinoma (HCC (show FAM126A Antibodies)) and contributes to cancer cell proliferation and invasion through regulation of FAK and AKT (show AKT1 Antibodies) signaling.

  4. LEFTY2 (show LEFTY2 Antibodies) down-regulates MKi67 (show MKI67 Antibodies) expression and FAK activity, up-regulates miR (show MLXIP Antibodies)-200a and E-cadherin (show CDH1 Antibodies), and is thus a powerful negative regulator of endometrial cell proliferation and migration.

  5. Calcium lactate (2.5 mM), alone and in combination with 5-FU, exerted antitumor activity against both anchored and unanchored colorectal cells via calcium-mediated FAK proteolysis and inhibition of EMT (show ITK Antibodies) markers, such as vimentin (show VIM Antibodies) and SNAIL (show SNAI1 Antibodies).

  6. From our data we conclude that targeting of CXCR4 (show CXCR4 Antibodies) and FAK may overcome ABCB1 (show ABCB1 Antibodies) and ABCC1 (show ABCC1 Antibodies)-dependent doxorubicin resistance in non-small cell lung carcinoma cells

  7. Periostin (show POSTN Antibodies) expression in human periodontal ligament fibroblasts promotes the migration of human mesenchymal stem cells through the alphavbeta3 integrin/FAK/PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway in vitro.

  8. High FAK expression is associated with cervical cancer.

  9. Studies propose that localization of FAK Y407, rather than FAK expression and overall FAK Y407 phosphorylation levels, is crucial for the control of cell motility of triple-negative breast cancer (TNBC) cell lines and suggest that subcellular localization, next to expression and activity levels, are important for understanding TNBC progression.

  10. FAK activation is necessary for the promotion of osteogenesis induced by extracorporeal shockwave.

Xenopus laevis PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.

  2. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.

  3. work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development

  4. These data suggest an important role for the FERM domain in the activation of FAK.

  5. FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (show BDNF Antibodies), while phosphorylation at Y925 controls the rate of point contact turnover.

  6. Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.

  7. FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.

Mouse (Murine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. FAK promotes nascent integrin adhesions (NA) assembly and timely turnover to couple lamellipodial protrusion to adhesions for efficient advance of the leading edge. Phosphorylation on Y397 of FAK promotes dense NA formation but is dispensable for transient NA stabilization and leading edge advance.

  2. this manuscript shows that endothelial cell FAK activity induces VCAM-1 (show VCAM1 Antibodies) expression and contributes to atherosclerosis

  3. FAK activation is necessary for the promotion of osteogenesis induced by extracorporeal shockwave.

  4. Data show that the essential oil (EO) decreased focal adhesion and invadopodia formation which was accompanied by a drastic downregulation of focal adhesion kinase (FAK) and proto-oncogene protein Src.

  5. results suggest that LPS (show TLR4 Antibodies)-stimulated macrophage mediators attenuate both FAK and Src (show SRC Antibodies) activations in osteoblast, suggesting a novel role for TNFalpha (show TNF Antibodies) on osteoblast performance

  6. Report phosphorylation sites in focal adhesion kinase and putative new binding partners.

  7. data indicate that PTPalpha (show PTPRA Antibodies) and FAK, which are enriched in FAs (show FAS Antibodies), interact with IP3R1 (show ITPR1 Antibodies) at adjacent ER sites to spatially sequester IL-1 (show IL1A Antibodies)-induced Ca(2 (show CA2 Antibodies)+) signalling

  8. FAK-regulated signalling module PDK1 (show PDPK1 Antibodies)-Akt (show AKT1 Antibodies)-p70S6K (show RPS6KB1 Antibodies) that controls Src's intracellular trafficking operates at Src (show SRC Antibodies)-containing autophagosomes.

  9. Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes.

  10. FAK deletion correlates with increased phosphorylation of Tks-5 (show SH3PXD2A Antibodies) (tyrosine kinase substrate (show IRS2 Antibodies) with five SH3 domain (show ITSN1 Antibodies)) and reactive oxygen species production.

Cow (Bovine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. RhoA (show RHOA Antibodies) and membrane fluidity mediates the spatially polarized Src (show SRC Antibodies)/FAK activation in response to shear stress.

  2. XIAP (show XIAP Antibodies) plays an essential role in shear stress-stimulated FAK phosphorylation.

  3. mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C (show PKC Antibodies)

  4. These results suggest that TGF-beta1 (show TGFB1 Antibodies)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (show SRC Antibodies)-dependent and -independent pathways.

  5. Results suggest focal adhesion kinase is involved in thrombospondin-1 (show THBS1 Antibodies)-induced vascular smooth muscle cell migration.

FAK (PTK2) Antigen Profile

Protein Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Gene names and symbols associated with PTK2

  • PTK2 protein tyrosine kinase 2 (PTK2) antibody
  • protein tyrosine kinase 2 (PTK2) antibody
  • protein tyrosine kinase 2 (Ptk2) antibody
  • protein tyrosine kinase 2 (ptk2) antibody
  • PTK2 protein tyrosine kinase 2 (Ptk2) antibody
  • Fadk antibody
  • FAK antibody
  • FAK1 antibody
  • FRNK antibody
  • mKIAA4203 antibody
  • p125FAK antibody
  • pp125FAK antibody
  • PPP1R71 antibody

Protein level used designations for PTK2

FADK 1 , FAK-related non-kinase polypeptide , PTK2 protein tyrosine kinase 2 , focal adhesion kinase 1 , focal adhesion kinase-related nonkinase , protein phosphatase 1 regulatory subunit 71 , protein phosphatase 1, regulatory subunit 71 , pp125FAK , protein-tyrosine kinase 2 , focal adhesion kinase pp125FAK , focal ashension kinase 1 , p41/p43FRNK , focal adhesion kinase

GENE ID SPECIES
100058245 Equus caballus
5747 Homo sapiens
25614 Rattus norvegicus
399286 Xenopus laevis
14083 Mus musculus
396416 Gallus gallus
475108 Canis lupus familiaris
506270 Bos taurus
Selected quality suppliers for anti-FAK (PTK2) Antibodies
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