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anti-PTK6 Protein tyrosine Kinase 6 (PTK6) Antibodies

The protein encoded by PTK6 is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Additionally we are shipping PTK6 Proteins (11) and PTK6 Kits (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTK6 5753 Q13882
PTK6 366275  
PTK6 20459 Q64434
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Top anti-PTK6 Antibodies at antibodies-online.com

Showing 10 out of 132 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PTK6 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from 293 cells treated with EGF 200ng/ml 30', using Breast Tumor Kinase (Phospho-Tyr447) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of NIH-3T3 cells, using Breast Tumor Kinase (Phospho-Tyr447) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-hPTK6-E26 Pab (ABIN392105) in A375 cell line lysate (35 µg/lane). hPTK6-E26(arrow) was detected using the purified polyclonal antibody (1:50 dilution). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from LOVO cells, using Breast Tumor Kinase Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of NIH-3T3 cells, using Breast Tumor Kinase (Ab-447) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using PTK6 mouse mAb against Hela (1), A549 (2) and MCF-7 (3) cell lysate. 100 μL Log in to see 3 to 4 Days
$442.20
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$283.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL Log in to see 14 to 21 Days
$291.50
Details
Human Mouse Un-conjugated IHC (p), ELISA Immunoperoxidase of monoclonal antibody to PTK6 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details

PTK6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PTK6 Antibodies

  1. Human Monoclonal PTK6 Primary Antibody for ELISA, WB - ABIN969373 : Wilks: Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. in Proceedings of the National Academy of Sciences of the United States of America 1989 (PubMed)
    Show all 4 references for ABIN969373

  2. Human Polyclonal PTK6 Primary Antibody for EIA, IHC (p) - ABIN359990 : Derry, Prins, Ray, Tyner: Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. in Oncogene 2003 (PubMed)
    Show all 3 references for ABIN359990

  3. Human Polyclonal PTK6 Primary Antibody for ELISA, WB - ABIN1533880 : Mitchell, Barker, Martindale, Kamalati, Lowe, Page, Gusterson, Crompton: Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours. in Oncogene 1994 (PubMed)
    Show all 2 references for ABIN1533880

  4. Human Monoclonal PTK6 Primary Antibody for IHC (p), ELISA - ABIN519484 : Akl, Ayoub, Mohyeldin, Busnena, Foudah, Liu, Sayed: Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models. in PLoS ONE 2014 (PubMed)
    Show all 2 references for ABIN519484

  5. Human Polyclonal PTK6 Primary Antibody for IHC (p), WB - ABIN392105 : Chen, Ma, Cao, Huang, Zeng, Wen: Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma. in Medical oncology (Northwood, London, England) 2014 (PubMed)
    Show all 2 references for ABIN392105

  6. Human Polyclonal PTK6 Primary Antibody for IF, ELISA - ABIN1531497 : Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... in Nature 2002 (PubMed)
    Show all 2 references for ABIN1531497

  7. Human Polyclonal PTK6 Primary Antibody for IF (p), IHC (p) - ABIN1713614 : Akl, Foudah, Ebrahim, Meyer, El Sayed: The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling. in Marine drugs 2014 (PubMed)

  8. Human Polyclonal PTK6 Primary Antibody for WB - ABIN2786824 : Lukong, Richard: Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration. in Cellular signalling 2008 (PubMed)

More Antibodies against PTK6 Interaction Partners

Human PTK6 Protein tyrosine Kinase 6 (PTK6) interaction partners

  1. PELP1 (show PELP1 Antibodies) interacted with GR to activate Brk expression.

  2. PTK6 prolongs S-phase and increases the ability of gemcitabine to cause DNA damage in vitro and in vivo

  3. BRK expression in a majority of CC can interact with RTK, augmenting growth and interfering with proliferation inhibitors (SAM68 (show KHDRBS1 Antibodies)). Therapeutically targeting BRK function (in addition to RTK) should be of benefit for CC treatment.

  4. Additive impact of HER2 (show ERBB2 Antibodies)-/PTK6-RNAi on interactions with HER3 (show ERBB3 Antibodies) or IGF-1R (show IGF1R Antibodies) leads to reduced breast cancer progression

  5. overexpression or knockdown of PTK6 or ERK1/2 effectively removed the inhibition of S1P-induced migration by miR-17.

  6. Establishment of cross talk between PTK6 and CagA (show S100A8 Antibodies) by functional studies may further elucidate the underlying biology of H. pylori-mediated gastric cancer

  7. PTK6 is expressed in the normal human mammary gland, but does not appear to be active and may have kinase-independent functions that are distinct from its cancer promoting activities at the membrane.

  8. Down-regulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.

  9. PTP1B (show PTPN1 Antibodies) inhibited BRK by dephosphorylating Tyr (show TYR Antibodies)-342, but activated SRC (show SRC Antibodies) by antagonizing PAG (show PRDX1 Antibodies)-dependent inhibition by CSK (show CSK Antibodies).

  10. Activating mutations in BRK in breast cancer may disrupt intramolecular interactions that normally maintain BRK in an autoinhibited conformation.

Mouse (Murine) PTK6 Protein tyrosine Kinase 6 (PTK6) interaction partners

  1. PTK6 prolongs S-phase and increases the ability of gemcitabine to cause DNA damage in vitro and in vivo

  2. Ptk6 promotes ERBB2 (show ERBB2 Antibodies)-induced mammary gland tumorigenesis in the mouse.

  3. Protein tyrosine kinase 6 has a role in mediating TNFalpha (show TNF Antibodies)-induced endothelial barrier dysfunction

  4. Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT (show AKT1 Antibodies).

  5. expression of Brk/PTK6 in non-transformed mammary epithelial cells mediates p38 MAPK (show MAPK14 Antibodies) phosphorylation and promotes increased cellular survival, delayed involution, and latent tumor formation.

  6. a novel function for PTK6 at the plasma membrane

  7. PTK6 promotes STAT3 (show STAT3 Antibodies) activation in the colon following injection of the carcinogen azoxymethane and regulates STAT3 (show STAT3 Antibodies) activity in mouse colon tumors.

  8. AKT (show AKT1 Antibodies) is a direct substrate of PTK6 and AKT (show AKT1 Antibodies) tyrosine residues 315 and 326 are phosphorylated by PTK6.

  9. PTK6 associates with nuclear and cytoplasmic beta-catenin (show CTNNB1 Antibodies) and inhibits beta-catenin (show CTNNB1 Antibodies)- and T-cell factor (TCF (show HNF4A Antibodies))-mediated transcription.

  10. The tyrosine kinases Brk/PTK6/Sik, Srm (show SRM Antibodies), Frk/Rak/Gtk (show FRK Antibodies)/Iyk/Bsk (show EPHA5 Antibodies), and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.

PTK6 Antigen Profile

Protein Summary

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PTK6

  • PTK6 protein tyrosine kinase 6 (PTK6) antibody
  • protein tyrosine kinase 6 (PTK6) antibody
  • protein tyrosine kinase 6 (Ptk6) antibody
  • PTK6 protein tyrosine kinase 6 (Ptk6) antibody
  • BRK antibody
  • Sik antibody
  • tks antibody
  • Tksk antibody

Protein level used designations for PTK6

PTK6 protein tyrosine kinase 6 , protein-tyrosine kinase 6-like , breast tumor kinase , protein-tyrosine kinase 6 , protein-tyrosine kinase BRK , tyrosine-protein kinase BRK , protein tyrosine kinase 6 , src-related intestinal kinase , tyrosine kinase identified from skin

GENE ID SPECIES
100060532 Equus caballus
100438236 Pongo abelii
100589028 Nomascus leucogenys
5753 Homo sapiens
366275 Rattus norvegicus
20459 Mus musculus
529814 Bos taurus
Selected quality suppliers for anti-PTK6 (PTK6) Antibodies
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