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The protein encoded by PTK6 is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Additionally we are shipping PTK6 Proteins (11) and PTK6 Kits (9) and many more products for this protein.
Showing 10 out of 141 products:
Human Monoclonal PTK6 Primary Antibody for ELISA, WB - ABIN969373
Wilks: Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. in Proceedings of the National Academy of Sciences of the United States of America 1989
Show all 4 references for ABIN969373
Human Polyclonal PTK6 Primary Antibody for EIA, IHC (p) - ABIN359990
Derry, Prins, Ray, Tyner: Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. in Oncogene 2003
Show all 3 references for ABIN359990
Human Polyclonal PTK6 Primary Antibody for ELISA, WB - ABIN1533880
Mitchell, Barker, Martindale, Kamalati, Lowe, Page, Gusterson, Crompton: Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours. in Oncogene 1994
Show all 2 references for ABIN1533880
Human Polyclonal PTK6 Primary Antibody for IHC (p), WB - ABIN392105
Chen, Ma, Cao, Huang, Zeng, Wen: Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma. in Medical oncology (Northwood, London, England) 2014
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Human Polyclonal PTK6 Primary Antibody for IF, ELISA - ABIN1531497
Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... in Nature 2002
Show all 2 references for ABIN1531497
Human Monoclonal PTK6 Primary Antibody for ELISA, WB - ABIN2869234
Liu, Zhang, Zhong, Li, Liu, Lin, Wu, Zeng: Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma. in Journal of translational medicine 2013
Human Polyclonal PTK6 Primary Antibody for IF (p), IHC (p) - ABIN1713614
Akl, Foudah, Ebrahim, Meyer, El Sayed: The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling. in Marine drugs 2014
Human Polyclonal PTK6 Primary Antibody for WB - ABIN2786824
Lukong, Richard: Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration. in Cellular signalling 2008
PELP1 (show PELP1 Antibodies) interacted with GR to activate Brk expression.
PTK6 prolongs S-phase and increases the ability of gemcitabine to cause DNA damage in vitro and in vivo
BRK expression in a majority of CC can interact with RTK, augmenting growth and interfering with proliferation inhibitors (SAM68 (show KHDRBS1 Antibodies)). Therapeutically targeting BRK function (in addition to RTK) should be of benefit for CC treatment.
Additive impact of HER2 (show ERBB2 Antibodies)-/PTK6-RNAi on interactions with HER3 (show ERBB3 Antibodies) or IGF-1R (show IGF1R Antibodies) leads to reduced breast cancer progression
overexpression or knockdown of PTK6 or ERK1/2 effectively removed the inhibition of S1P-induced migration by miR-17.
Establishment of cross talk between PTK6 and CagA (show S100A8 Antibodies) by functional studies may further elucidate the underlying biology of H. pylori-mediated gastric cancer
PTK6 is expressed in the normal human mammary gland, but does not appear to be active and may have kinase-independent functions that are distinct from its cancer promoting activities at the membrane.
Down-regulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.
PTP1B (show PTPN1 Antibodies) inhibited BRK by dephosphorylating Tyr (show TYR Antibodies)-342, but activated SRC (show SRC Antibodies) by antagonizing PAG (show PRDX1 Antibodies)-dependent inhibition by CSK (show CSK Antibodies).
Activating mutations in BRK in breast cancer may disrupt intramolecular interactions that normally maintain BRK in an autoinhibited conformation.
Ptk6 promotes ERBB2 (show ERBB2 Antibodies)-induced mammary gland tumorigenesis in the mouse.
Protein tyrosine kinase 6 has a role in mediating TNFalpha (show TNF Antibodies)-induced endothelial barrier dysfunction
Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT (show AKT1 Antibodies).
expression of Brk/PTK6 in non-transformed mammary epithelial cells mediates p38 MAPK (show MAPK14 Antibodies) phosphorylation and promotes increased cellular survival, delayed involution, and latent tumor formation.
a novel function for PTK6 at the plasma membrane
PTK6 promotes STAT3 (show STAT3 Antibodies) activation in the colon following injection of the carcinogen azoxymethane and regulates STAT3 (show STAT3 Antibodies) activity in mouse colon tumors.
AKT (show AKT1 Antibodies) is a direct substrate of PTK6 and AKT (show AKT1 Antibodies) tyrosine residues 315 and 326 are phosphorylated by PTK6.
PTK6 associates with nuclear and cytoplasmic beta-catenin (show CTNNB1 Antibodies) and inhibits beta-catenin (show CTNNB1 Antibodies)- and T-cell factor (TCF (show HNF4A Antibodies))-mediated transcription.
The tyrosine kinases Brk/PTK6/Sik, Srm (show SRM Antibodies), Frk/Rak/Gtk (show FRK Antibodies)/Iyk/Bsk (show EPHA5 Antibodies), and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants.
PTK6 protein tyrosine kinase 6
, protein-tyrosine kinase 6-like
, breast tumor kinase
, protein-tyrosine kinase 6
, protein-tyrosine kinase BRK
, tyrosine-protein kinase BRK
, protein tyrosine kinase 6
, src-related intestinal kinase
, tyrosine kinase identified from skin