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The protein encoded by PTK6 is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Additionally we are shipping PTK6 Antibodies (139) and PTK6 Proteins (11) and many more products for this protein.
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PELP1 (show PELP1 ELISA Kits) interacted with GR to activate Brk expression.
PTK6 prolongs S-phase and increases the ability of gemcitabine to cause DNA damage in vitro and in vivo
BRK expression in a majority of CC can interact with RTK, augmenting growth and interfering with proliferation inhibitors (SAM68 (show KHDRBS1 ELISA Kits)). Therapeutically targeting BRK function (in addition to RTK) should be of benefit for CC treatment.
Additive impact of HER2 (show ERBB2 ELISA Kits)-/PTK6-RNAi on interactions with HER3 (show ERBB3 ELISA Kits) or IGF-1R (show IGF1R ELISA Kits) leads to reduced breast cancer progression
overexpression or knockdown of PTK6 or ERK1/2 effectively removed the inhibition of S1P-induced migration by miR-17.
Establishment of cross talk between PTK6 and CagA (show S100A8 ELISA Kits) by functional studies may further elucidate the underlying biology of H. pylori-mediated gastric cancer
PTK6 is expressed in the normal human mammary gland, but does not appear to be active and may have kinase-independent functions that are distinct from its cancer promoting activities at the membrane.
Down-regulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.
PTP1B (show PTPN1 ELISA Kits) inhibited BRK by dephosphorylating Tyr (show TYR ELISA Kits)-342, but activated SRC (show SRC ELISA Kits) by antagonizing PAG (show PRDX1 ELISA Kits)-dependent inhibition by CSK (show CSK ELISA Kits).
Activating mutations in BRK in breast cancer may disrupt intramolecular interactions that normally maintain BRK in an autoinhibited conformation.
Ptk6 promotes ERBB2 (show ERBB2 ELISA Kits)-induced mammary gland tumorigenesis in the mouse.
Protein tyrosine kinase 6 has a role in mediating TNFalpha (show TNF ELISA Kits)-induced endothelial barrier dysfunction
Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT (show AKT1 ELISA Kits).
expression of Brk/PTK6 in non-transformed mammary epithelial cells mediates p38 MAPK (show MAPK14 ELISA Kits) phosphorylation and promotes increased cellular survival, delayed involution, and latent tumor formation.
a novel function for PTK6 at the plasma membrane
PTK6 promotes STAT3 (show STAT3 ELISA Kits) activation in the colon following injection of the carcinogen azoxymethane and regulates STAT3 (show STAT3 ELISA Kits) activity in mouse colon tumors.
AKT (show AKT1 ELISA Kits) is a direct substrate of PTK6 and AKT (show AKT1 ELISA Kits) tyrosine residues 315 and 326 are phosphorylated by PTK6.
PTK6 associates with nuclear and cytoplasmic beta-catenin (show CTNNB1 ELISA Kits) and inhibits beta-catenin (show CTNNB1 ELISA Kits)- and T-cell factor (TCF (show HNF4A ELISA Kits))-mediated transcription.
The tyrosine kinases Brk/PTK6/Sik, Srm (show SRM ELISA Kits), Frk/Rak/Gtk (show FRK ELISA Kits)/Iyk/Bsk (show EPHA5 ELISA Kits), and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants.
PTK6 protein tyrosine kinase 6
, protein-tyrosine kinase 6-like
, breast tumor kinase
, protein-tyrosine kinase 6
, protein-tyrosine kinase BRK
, tyrosine-protein kinase BRK
, protein tyrosine kinase 6
, src-related intestinal kinase
, tyrosine kinase identified from skin