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PXK binds to the Na,K-ATPase beta-1 (ATP1B1\; MIM 182330) and beta-3 (ATP1B3\; MIM 601867) subunits and modulates both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005 [PubMed 16135750]).[supplied by OMIM, Mar 2008].. Additionally we are shipping PXK Antibodies (52) and PXK Kits (1) and many more products for this protein.
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Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis
genetic association study in Han population in China: Data suggest an SNP in PXK [rs2176082(C/T); but not rs6445975(G/T)] is associated with recurrent pregnancy loss; SNPs in KIAA0319L (show KIAA0319L Proteins) [rs2275247(A/G)] or JAZF1 (show JAZF1 Proteins) [rs1635852(C/T)] are not associated.
Results confirm the genetic association of the locus 3p14.3 with systemic lupus erythematosus in Europeans and point to the ABHD6 (show ABHD6 Proteins) and not PXK, as the major susceptibility gene in the region.
study determined that the previously described systemic lupus erythematosus susceptibility loci PXK (P = 3.27 x 10(-11), OR = 1.20) and JAZF1 (show JAZF1 Proteins) (P = 1.11 x 10(-8), OR = 1.13) are shared with systemic sclerosis
The rs6445975 polymorphism of PXK and the rs2304256 polymorphism of tyrosine kinase 2 (show TYK2 Proteins) are associated with the development of systemic lupus erythematosus in Europeans
The association of PXK rs6445975 with systemic lupus erythematosus that was previously observed in Caucasians was not replicated in Koreans or in Hong Kong Chinese.
These results indicate that PXK plays a critical role in epidermal growth factor receptor (show EGFR Proteins) trafficking through modulating ligand-induced ubiquitination of the receptor.
MONaKA modulates brain Na,K-ATPase (show ATP1A1 Proteins) by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission [MONaKA]
study presents four new regions having genetic associations with systemic lupus erythematosus in women of European descent: ITGAM (show ITGAM Proteins), KIAA1542, PXK and rs10798269
MONaKA modulates brain Na,K-ATPase (show ATP1A1 Proteins) by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission.
PXK binds to the Na,K-ATPase beta-1 (ATP1B1\; MIM 182330) and beta-3 (ATP1B3\; MIM 601867) subunits and modulates both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005
PX domain-containing protein kinase-like protein
, PX ser/thr kinase v2
, PX serine/threonine kinase
, modulator of Na,K-ATPase long form
, modulator of Na,K-ATPase