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Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. Additionally we are shipping PYD (Pyrin Domain) Containing 1 Antibodies (41) and many more products for this protein.
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Changes in the tertiary structure of mutated pyrin (show MEFV Proteins) B30.2 domain interrupting the formation of the pyrin (show MEFV Proteins)-caspase-1 (show CASP1 Proteins) complex are related to the manifestations of Mediterranean familial fever.
X-ray diffraction data were collected to a resolution of 3.6 A from a crystal belonging to the cubic space group P23 with unit-cell parameters a=b=c=94.12 A, alpha=beta=gamma=90.00 degrees .
NMR assignment of human ASC2 (show NCOA6 Proteins), a self contained protein interaction domain involved in apoptosis and inflammation.
analysis of the 3D structure of human ASC2 (show NCOA6 Proteins) protein involved in apoptosis and inflammation
ASC2 (show NCOA6 Proteins) is a pyrin (show MEFV Proteins) domain-only protein that regulates inflammatory signaling
POP1/ASC2 associates with ASC (show PYCARD Proteins) via PAAD-PAAD interactions and modulates NF-kappa B (show NFKB1 Proteins) and pro-caspase-1 (show CASP1 Proteins) regulation by this adapter protein (show TOLLIP Proteins)
Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
PAAD-only protein 1
, pyrin domain containing 1
, pyrin domain-containing protein 1
, pyrin-domain containing protein 1
, pyrin-only protein 1