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PAF1 encodes a subunit of the polymerase associated factor (PAF1) complex. Additionally we are shipping PAF1 Proteins (3) and many more products for this protein.
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Propose that degradation of MYC (show MYC Antibodies) limits the accumulation of MYC (show MYC Antibodies)/PAF1C complexes during transcriptional activation.
Mechanistic studies indicated that PAF1C could promote lung cancer cell proliferation through regulating c-MYC (show MYC Antibodies) transcription.
CNOT4 (show CNOT4 Antibodies) controls the degradation of chromatin-unbound PAF1 (show PEX2 Antibodies) via the 26S proteasome (show Psmd4 Antibodies).
this study found that Pol II-associated factor 1 (PAF1 (show PEX2 Antibodies)) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb (show CDK9 Antibodies)) directly regulates the initial recruitment of PAF1 (show PEX2 Antibodies) complex (PAF1C) to genes, and that the subsequent recruitment of CDK12 (show CRKRS Antibodies) is dependent on PAF1C.
This study reveals an evolutionarily conserved role for PAF1 (show PEX2 Antibodies) as a regulator of promoter-proximal pausing by RNA Pol II in all metazoans, including human.
PD2 is a novel cancer stem cell (CSC) maintenance protein, loss of which renders the CSCs more susceptible to drug-induced cell death.
Together, these results indicate that human adenovirus E1A (show BCKDHA Antibodies) uses hBre1 (show RNF20 Antibodies) to recruit the hPaf1 complex in order to optimally activate viral early transcription by enhancing transcriptional elongation.
The results show that the Paf1 (show PEX2 Antibodies)/Leo1 (show LEO1 Antibodies) heterodimer is necessary for its binding to histone H3 (show HIST3H3 Antibodies), the histone octamer, and nucleosome in vitro.
E1A (show BCKDHA Antibodies) changes the function of hBre1 (show RNF20 Antibodies) from a ubiquitin ligase involved in substrate selection to a scaffold which recruits hPaf1 as a means to stimulate transcription and transcription-coupled histone modifications.
Data indicate that the Plus3 domain of the Rtf1 (show RTF1 Antibodies) subunit mediates Paf1C recruitment to genes by binding a repeating domain within the phosphorylated elongation factor (show TSFM Antibodies) Spt5 (show SUPT5H Antibodies).
link Paf1C with PolII elongation and RNA processing indicates that Paf1C subunits could play roles in controlling transcript length through suppression of PolII accumulation at transcription start site (TSS (show RPL38 Antibodies))-proximal pA sites
The PAF1 (show PEX2 Antibodies) complex is required for mammalian development, likely through regulation of H3K36me3, indicating a functional conservation of the PAF1 (show PEX2 Antibodies) complex from yeast to mammals in vivo.
As part of a cell-intrinsic transcriptional pathway, Paf1 (show PEX2 Antibodies) regulates neuronal migration in the brain.
MLL (show MLL Antibodies) interacts directly with the polymerase associated factor complex (PAFc) via Paf1 (show PEX2 Antibodies) and CTR9 (show CTR9 Antibodies). PAFc augments MLL (show MLL Antibodies) and MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) mediated transcriptional activation of Hoxa9 (show HOXA9 Antibodies) and their interaction is essential for leukemogenesis.
show that Paf1/PD2 is overexpressed in mouse embryonic stem cells (ESCs (show NR2E3 Antibodies)) and is involved in the maintenance of mouse ESCs (show NR2E3 Antibodies).
The PAF1 complex differentially regulates cardiomyocyte specification.
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
RNA polymerase II-associated factor 1 homolog
, pancreatic differentiation protein 2
, PD2-like protein
, paf1, RNA polymerase II associated factor, homolog, like