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Paf1, RNA Polymerase II Associated Factor, Homolog (S. Cerevisiae) Proteins (PAF1)

PAF1 encodes a subunit of the polymerase associated factor (PAF1) complex. Additionally we are shipping PAF1 Antibodies (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PAF1 54623 Q8N7H5
PAF1 54624 Q8K2T8
PAF1 361531 Q4V886
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Top PAF1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,527.33
Details

PAF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

Rat (Rattus)

More Proteins for Paf1, RNA Polymerase II Associated Factor, Homolog (S. Cerevisiae) (PAF1) Interaction Partners

Human Paf1, RNA Polymerase II Associated Factor, Homolog (S. Cerevisiae) (PAF1) interaction partners

  1. Propose that degradation of MYC (show MYC Proteins) limits the accumulation of MYC (show MYC Proteins)/PAF1C complexes during transcriptional activation.

  2. Mechanistic studies indicated that PAF1C could promote lung cancer cell proliferation through regulating c-MYC (show MYC Proteins) transcription.

  3. CNOT4 (show CNOT4 Proteins) controls the degradation of chromatin-unbound PAF1 (show PEX2 Proteins) via the 26S proteasome (show Psmd4 Proteins).

  4. this study found that Pol II-associated factor 1 (PAF1 (show PEX2 Proteins)) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb (show CDK9 Proteins)) directly regulates the initial recruitment of PAF1 (show PEX2 Proteins) complex (PAF1C) to genes, and that the subsequent recruitment of CDK12 (show CRKRS Proteins) is dependent on PAF1C.

  5. This study reveals an evolutionarily conserved role for PAF1 (show PEX2 Proteins) as a regulator of promoter-proximal pausing by RNA Pol II in all metazoans, including human.

  6. PD2 is a novel cancer stem cell (CSC) maintenance protein, loss of which renders the CSCs more susceptible to drug-induced cell death.

  7. Together, these results indicate that human adenovirus E1A (show BCKDHA Proteins) uses hBre1 (show RNF20 Proteins) to recruit the hPaf1 complex in order to optimally activate viral early transcription by enhancing transcriptional elongation.

  8. The results show that the Paf1 (show PEX2 Proteins)/Leo1 (show LEO1 Proteins) heterodimer is necessary for its binding to histone H3 (show HIST3H3 Proteins), the histone octamer, and nucleosome in vitro.

  9. E1A (show BCKDHA Proteins) changes the function of hBre1 (show RNF20 Proteins) from a ubiquitin ligase involved in substrate selection to a scaffold which recruits hPaf1 as a means to stimulate transcription and transcription-coupled histone modifications.

  10. Data indicate that the Plus3 domain of the Rtf1 (show RTF1 Proteins) subunit mediates Paf1C recruitment to genes by binding a repeating domain within the phosphorylated elongation factor (show TSFM Proteins) Spt5 (show SUPT5H Proteins).

Mouse (Murine) Paf1, RNA Polymerase II Associated Factor, Homolog (S. Cerevisiae) (PAF1) interaction partners

  1. link Paf1C with PolII elongation and RNA processing indicates that Paf1C subunits could play roles in controlling transcript length through suppression of PolII accumulation at transcription start site (TSS (show RPL38 Proteins))-proximal pA sites

  2. The PAF1 (show PEX2 Proteins) complex is required for mammalian development, likely through regulation of H3K36me3, indicating a functional conservation of the PAF1 (show PEX2 Proteins) complex from yeast to mammals in vivo.

  3. As part of a cell-intrinsic transcriptional pathway, Paf1 (show PEX2 Proteins) regulates neuronal migration in the brain.

  4. MLL (show MLL Proteins) interacts directly with the polymerase associated factor complex (PAFc) via Paf1 (show PEX2 Proteins) and CTR9. PAFc augments MLL (show MLL Proteins) and MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) mediated transcriptional activation of Hoxa9 (show HOXA9 Proteins) and their interaction is essential for leukemogenesis.

  5. show that Paf1/PD2 is overexpressed in mouse embryonic stem cells (ESCs (show NR2E3 Proteins)) and is involved in the maintenance of mouse ESCs (show NR2E3 Proteins).

Zebrafish Paf1, RNA Polymerase II Associated Factor, Homolog (S. Cerevisiae) (PAF1) interaction partners

  1. The PAF1 complex differentially regulates cardiomyocyte specification.

PAF1 Protein Profile

Protein Summary

This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PAF1

  • Paf1, RNA polymerase II associated factor, homolog (paf1)
  • RNA polymerase II-associated factor 1 homolog (LOC100019208)
  • RNA polymerase II-associated factor 1 homolog (LOC100161171)
  • Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) (PAF1)
  • RNA polymerase II-associated factor 1 homolog (paf1)
  • RNA polymerase II-associated factor 1 homolog (LOC100411768)
  • RNA polymerase II-associated factor 1 homolog (LOC100465029)
  • RNA polymerase II-associated factor 1 homolog (LOC100543667)
  • RNA polymerase II-associated factor 1 homolog (LOC100594485)
  • RNA polymerase II-associated factor 1 homolog (LOC100625528)
  • RNA polymerase II-associated factor 1 homolog (LOC100639019)
  • RNA polymerase II-associated factor 1 homolog (LOC100650306)
  • Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) (Paf1)
  • paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) (paf1)
  • 5730511K23Rik protein
  • AA675045 protein
  • F23149_1 protein
  • im:6906070 protein
  • paf1 protein
  • paf1l protein
  • PD2 protein
  • RGD1306219 protein
  • wu:fb80a09 protein

Protein level used designations for PAF1

RNA polymerase II-associated factor 1 homolog , pancreatic differentiation protein 2 , PD2-like protein , paf1, RNA polymerase II associated factor, homolog, like

GENE ID SPECIES
394974 Xenopus (Silurana) tropicalis
100019208 Monodelphis domestica
100161171 Acyrthosiphon pisum
100172552 Pongo abelii
100194999 Salmo salar
100411768 Callithrix jacchus
100465029 Ailuropoda melanoleuca
100514194 Sus scrofa
100543667 Meleagris gallopavo
100594485 Nomascus leucogenys
100625528 Sus scrofa
100639019 Amphimedon queenslandica
100650306 Bombus terrestris
446278 Xenopus laevis
54623 Homo sapiens
54624 Mus musculus
361531 Rattus norvegicus
528744 Bos taurus
553020 Danio rerio
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