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PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. Additionally we are shipping Paired Box 2 Antibodies (95) and Paired Box 2 Proteins (13) and many more products for this protein.
PAX2 gene silencing can significantly inhibit the process of epithelial-mesenchymal transition (EMT (show ITK ELISA Kits)) of renal tubular cells in rats with advanced fibrosis.
The results of this study identify several new mutations of PAX2, and sequence variants in four additional genes, including a novel potentially pathogenic mutation in KIF26B, which may play a role in the pathogenesis of Renal Coloboma Syndrome.
data suggested the differential regulation of hDAO expression by two promoters whose activities may be modulated by the binding of PAX2 and PAX5 (show PAX5 ELISA Kits)
Homozygosity for the risk alleles of RET (show RET ELISA Kits) and PAX2 was not seen in the late onset group in primary hyperoxaluria type 1 patients.
PAX2 and PAX8 (show PAX8 ELISA Kits) are useful biomarker in the differential diagnosis of ovarian serous and mucinous tumors
The 798C>T/909A>C PAX2 genotype did not increase the susceptibility to HenochSchonlein purpura (HSP), but it was likely to increase the susceptibility of kidney involvement in HSP patients.
Novel PAX2 targets included multiple genes encoding proteins with predicted functions in the epididymis epithelium.
Results showed that PAX2 expression is significantly overexpressed in esophageal squamous cell carcinoma tissues and IL-5 (show IL5 ELISA Kits) is identified as PAX2's effector for metastasis.
Report increased Pax2 expression in the ureter epithelium of children with vesicoureteric reflux.
Pax2 may play a role in kidney development by regulating the expression of TBX1 (show TBX1 ELISA Kits).
PAX2 may not be a classical oncogene (show RAB1A ELISA Kits) or tumor suppressor but instead can act in either role by differential regulation of COX2 (show COX2 ELISA Kits) and/or HTRA1 (show HTRA1 ELISA Kits).
Dicer (show DICER1 ELISA Kits) ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth.
Pax2 specifies the intermediate mesoderm and renal epithelial cells through epigenetic mechanisms and in part by repressing paraxial mesodermal fate.
Data indicate hyperproliferation, impaired differentiation and increased apoptosis of neural progenitors in the cerebellum of lethal giant larvae homolog 1 (Lgl1)-Pax2 protein knockout embryos.
a core regulatory subcircuit composed of Pax2/8, Gata3 (show GATA3 ELISA Kits) and Lim1 (show LHX1 ELISA Kits) turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
the role of Pax2 protein levels in determining correct renal architecture and cell fate in urogenital development.
cross-talk between p53 (show TP53 ELISA Kits) and Pax2 provides a transcriptional platform that promotes nephrogenesis, thus contributing to nephron endowment
Hnf1b (show HNF1B ELISA Kits) and Pax2 operate to control kidney morphogenesis and ureter differentiation.
Hyperactivated Wnt (show WNT2 ELISA Kits) signaling increased expression of the transcription factor Pax2 in the cells lining cysts in autosomal dominant polycystic kidney disease.
Pax2 is essential for mouse development and regulates prostatic ductal growth, branching, and lobe-specific identitiy.
Pax2a and Pax8 (show PAX8 ELISA Kits) regulate cell differentiation during sensory placode formation
Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development
pax8 (show PAX8 ELISA Kits) works with related genes pax2a/pax2b to downregulate otic expression of foxi1 (show FOXI1 ELISA Kits), a necessary step for further otic development
wnt1 (show WNT1 ELISA Kits) and wnt10b (show WNT10B ELISA Kits) are required to maintain threshold levels of Pax2.1 and Fgf8 (show FGF8 ELISA Kits) at the midbrain-hindbrain boundary.
hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
Pax2a and Pax8 (show PAX8 ELISA Kits) are the main effectors downstream of Fgf signals in ear formation
pax8 (show PAX8 ELISA Kits) is initially required for normal otic induction, and subsequently pax8 (show PAX8 ELISA Kits), pax2a and pax2b act redundantly to maintain otic fate
Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons.
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
paired box 2
, paired box gene 2
, paired box protein Pax-2
, paired-box protein Pax-2
, paired-box containing protein Pax-2
, paired box homeotic gene 2
, optic disc coloboma
, no isthmus protein
, paired box gene 2.1
, paired box homeotic gene 2a
, paired box protein Pax-2a