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Paired Box 3 Proteins (PAX3)

PAX3 is a member of the paired box (PAX) family of transcription factors. Additionally we are shipping Paired Box 3 Antibodies (114) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PAX3 5077 P23760
Rat PAX3 PAX3 114502  
PAX3 18505 P24610
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Top Paired Box 3 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,296.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PAX3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Paired Box 3 (PAX3) Interaction Partners

Horse (Equine) Paired Box 3 (PAX3) interaction partners

  1. A novel missense variant, PAX3:p.Pro32Arg, in Appaloosa horses with a splashed white phenotype in addition to their leopard complex spotting patterns.

  2. several independent mutations in MITF (show MITF Proteins) and PAX3 together with known variants in the EDNRB (show EDNRB Proteins) and KIT genes explain a large proportion of horses with the more extreme white spotting phenotypes

Xenopus laevis Paired Box 3 (PAX3) interaction partners

  1. The pax3 and Pax7 (show PAX7 Proteins) paralogs cooperate in neural and neural crest patterning using distinct molecular mechanisms, in Xenopus laevis embryos.

Human Paired Box 3 (PAX3) interaction partners

  1. Secreted Frizzled-Related Protein 3 (SFRP3 (show FRZB Proteins)) Is Required for Tumorigenesis of PAX3-FOXO1 (show FOXO1 Proteins)-Positive Alveolar Rhabdomyosarcoma

  2. findings suggest a tumor suppressor role for APC (show APC Proteins)/C(Cdh1 (show CDH1 Proteins)) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma.

  3. PAX3 phosphorylation has a role in determing melanoma phenotypes by affecting proliferation, invasion, and transformation

  4. All affected members of pedigree IR-WS-20 carried the mutation c.1024_1040 del AGCACGATTCCTTCCAA in exon 7 of PAX3, while none of the unaffected members and 50 of the ethnic matched controls tested had this deletion.

  5. PAX3 differentially regulates various downstream target genes involved in cell proliferation in melanoma cells compared to melanocytes.

  6. The results expand the spectrum of PAX3 mutations and may have implications for the genetic counseling of Waardenburg syndrome in Iran.

  7. Report novel PAX3-NCOA1 (show NCOA1 Proteins) gene fusions in biphenotypic sinonasal sarcomas with focal rhabdomyoblastic differentiation.

  8. PAX3-FOXO1 (show FOXO1 Proteins) may contribute to tumor formation.

  9. Data show that transcription factors PAX3 and FOXD3 (show FOXD3 Proteins)-mediated melanoma cell migration is dependent on promoting the expression of chemokine receptor CXCR4 (show CXCR4 Proteins).

  10. findings suggest that PAX3 WS mutants interfere with the normal functions of PAX3 in a dominant negative manner, which is important to the understanding of the pathogenesis of Waardenburg syndrome

Cow (Bovine) Paired Box 3 (PAX3) interaction partners

  1. SNP and haplotype analysis of PAX3 gene provide evidence for association with growth traits in Chinese cattle.

Mouse (Murine) Paired Box 3 (PAX3) interaction partners

  1. The Pax3(GFP) allele proved to be a convenient marker to identify and directly sort heterogeneous populations of melanoma cells within the tumor bulk at each stage of melanoma progression.

  2. deletion of Foxc1 (show FOXC1 Proteins) and Foxc2 (show FOXC2 Proteins) specifically in Pax3-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb

  3. findings suggest a tumor suppressor role for APC (show APC Proteins)/C(Cdh1 (show CDH1 Proteins)) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma.

  4. These results demonstrate a requirement for endoglin (show ENG Proteins) in descendants of Pax3-expressing vascular cell precursors.

  5. Results suggest that regional Pax3 expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B (show PDGFB Proteins)-induced brainstem gliomagenesis

  6. we show that the ability of Pax3 to induce the skeletal myogenic cell fate occurs at the expenses of the cardiac lineage.

  7. Pax3 activity is regulated by the Hippo pathway and Pax (show PXN Proteins) factors are Hippo effectors.

  8. Loss of Pax3 expression is associated with craniofacial abnormalities.

  9. the PAX3-NCOA2 (show NCOA2 Proteins) fusion gene has a dual role in the tumorigenesis of rhabdomyosarcoma

  10. positive input from the neural-specific transcription factor Sox2 (show SOX2 Proteins). Altogether, our data provide important mechanistic insights into the coordinated integration of different signaling pathways on a short Pax3 CRM.

Zebrafish Paired Box 3 (PAX3) interaction partners

  1. BMP, Wnt (show WNT2 Proteins) and FGF signaling are needed for expression of the neural plate border specifiers pax3a and zic3 (show ZIC3 Proteins) in zebrafish

  2. evidence of YAP's role in regulating pax3 neural crest expression

  3. Pax3 in zebrafish is required for specification of two specific lineages of neural crest, xanthophores and enteric neurons.

Paired Box 3 (PAX3) Protein Profile

Protein Summary

This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2\;13)(q35\;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.

Gene names and symbols associated with Paired Box 3 Proteins (PAX3)

  • paired box 3 (PAX3)
  • paired box 3 (pax3)
  • paired box 3 (pax3-b)
  • paired box 3 (Pax3)
  • paired box gene 3 (Pax3)
  • paired box gene 3a (pax3a)
  • CDHS protein
  • HUP2 protein
  • Pax-3 protein
  • pax3 protein
  • pax3b protein
  • Sp protein
  • splotch protein
  • WS1 protein
  • WS3 protein
  • xpax3 protein
  • xPax3-B protein
  • zgc:92547 protein

Protein level used designations for Paired Box 3 Proteins (PAX3)

paired box 3 , paired box protein 3 , paired box gene 3 (Waardenburg syndrome 1) , Paired-domain transcription factor Pax3 , Waardenburg syndrome 1 , paired box protein Pax-3 , paired-box 3 , paired box protein Pax-3-like , paired box 3 b , paired box protein Pax-3-B , paired-domain transcription factor Pax3-B , paired box gene 3 , paired box homeotic gene 3 , paired domain gene 3 , paired domain gene HuP2 , paired-box 3 protein , homeodomain protein PAX3 , etID309899.2

GENE ID SPECIES
414901 Sus scrofa
448464 Xenopus (Silurana) tropicalis
459971 Pan troglodytes
705315 Macaca mulatta
100056517 Equus caballus
100357318 Oryctolagus cuniculus
100406473 Callithrix jacchus
100468866 Ailuropoda melanoleuca
100560571 Anolis carolinensis
100591131 Nomascus leucogenys
496377 Xenopus laevis
374127 Gallus gallus
5077 Homo sapiens
488544 Canis lupus familiaris
540951 Bos taurus
114502 Rattus norvegicus
18505 Mus musculus
30532 Danio rerio
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