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Paired Box 5 Proteins (PAX5)

PAX5 encodes a member of the paired box (PAX) family of transcription factors. Additionally we are shipping PAX5 Antibodies (167) and PAX5 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PAX5 5079 Q02548
Rat PAX5 PAX5 500453  
PAX5 18507 Q02650
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Top PAX5 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

PAX5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Paired Box 5 (PAX5) Interaction Partners

Human Paired Box 5 (PAX5) interaction partners

  1. PAX5 methylated imprint margins may signify recurrence in head and neck squamous cell carcinoma

  2. Authors demonstrate leukemogenicity of PAX5-PML (show PML Proteins) by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk (show BLNK Proteins)) is repressed by PAX5-PML (show PML Proteins) in leukemia cells; enforced expression of Blnk (show BLNK Proteins) increases survival despite introduction of PAX5-PML (show PML Proteins).

  3. PAX5 deletion is an independent risk factor for DFS (show FST Proteins) in B-ALL children.

  4. Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in mantle cell lymphoma patients independent (show CCND1 Proteins) of CCND1.

  5. This is the first reported case of a novel complex variant translocation of t(11;14)(q13;q32) and t(9;14)(p13;q32)in PAX5-positive plasma cell myeloma.

  6. data suggested the differential regulation of hDAO expression by two promoters whose activities may be modulated by the binding of PAX2 (show PAX2 Proteins) and PAX5

  7. Cells from PAX5 translocated patients show LCK (show LCK Proteins) up-regulation and over-activation, as well as STAT5 (show STAT5A Proteins) hyper-phosphorylation, compared to PAX5 wt and PAX5 deleted cases.

  8. Increased hypermethylation of PAX5 is associated with Triple negative breast cancer.

  9. PAX5 gene translocation is associated with B-cell precursor acute lymphoblastic leukemia.

  10. These findings indicated that the methylated CpG -236 of PAX5 promoter has the potential applicability for clinical evaluation the prognosis of gastric cancer

Xenopus laevis Paired Box 5 (PAX5) interaction partners

  1. Pax5 transcription factor cooperates in patterning the Xenopus brain.

Mouse (Murine) Paired Box 5 (PAX5) interaction partners

  1. Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in mantle cell lymphoma independent of CCND1 (show CCND1 Proteins).

  2. Spleen-specific isoform of Pax5 and Ataxin-7 can be considered as spleen-specific unique molecular markers for the evaluation of splenomegaly and lympho-proliferative disorders.

  3. Pax5 and Ebf1 (show EBF1 Proteins) collaborate to modulate the transcriptional response to Notch (show NOTCH1 Proteins) signaling, and their combined heterozygous loss allows for T-lineage conversion of B cell progenitors.

  4. a dramatic increase in the frequency of pro-B cell leukemia was observed in mice with combined heterozygous mutations in the Ebf1 (show EBF1 Proteins) and Pax5 genes, revealing a synergistic effect of combined dose reduction of these proteins

  5. These results show that in contrast to simple Pax5 haploinsufficiency, multiple sequential alterations targeting lymphoid development are central to leukemogenesis and contribute to the arrest in lymphoid maturation characteristic of ALL.

  6. miR (show MLXIP Proteins)-155 inhibits PU.1 expression, leading to Pax5 down-regulation and the initiation of the plasma cell differentiation pathway.

  7. restoring endogenous Pax5 expression in established B-ALL triggers immunophenotypic maturation and durable disease remission by engaging a transcriptional program reminiscent of normal B-cell differentiation

  8. Pax5 in GABAergic neurons is essential for normal ventricular development.

  9. results suggest that osteoblastic Pax5 would play a role in ovariectomy-induced bone loss through a mechanism relevant to the promotion of both osteoblastic bone formation and osteoclastic bone resorption in vivo

  10. Pax5 regulates Aicda (show AICDA Proteins) transcription through its C-terminal-activation domain

Zebrafish Paired Box 5 (PAX5) interaction partners

  1. pax5 works in conjunction with fgf3 (show FGF3 Proteins) and pax2a to establish and/or maintain the utricular macula and is essential for vestibular function.

PAX5 Protein Profile

Protein Summary

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9\;14)(p13\;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Gene names and symbols associated with Paired Box 5 Proteins (PAX5)

  • paired box 5 (PAX5)
  • paired box 5 (pax5)
  • paired box 5 (Pax5)
  • paired box gene 5 (Pax5)
  • paired box gene 5 (pax5)
  • BSAP protein
  • EBB-1 protein
  • KLP protein
  • noi protein
  • Pax-5 protein
  • pax2.1 protein
  • pax2a protein
  • PAX5 protein
  • pax5-a protein
  • paxzf-b protein
  • Pax[Zf-b] protein
  • RGD1565236 protein

Protein level used designations for Paired Box 5 Proteins (PAX5)

paired box 5 , paired box gene 5 (B-cell lineage specific activator) , paired box protein Pax-5 , paired box protein Pax-5-like , B-cell lineage specific activator , paired box homeotic gene 5 , paired domain gene 5 , transcription factor PAX 5 , XPax-5 , B-cell-specific transcription factor , Pax5 variant 1 , Pax5 variant 2 , No isthmus protein

716839 Macaca mulatta
747452 Pan troglodytes
100055252 Equus caballus
100389113 Callithrix jacchus
100457719 Pongo abelii
100481668 Ailuropoda melanoleuca
100586040 Nomascus leucogenys
5079 Homo sapiens
378499 Xenopus laevis
387330 Gallus gallus
612021 Canis lupus familiaris
500453 Rattus norvegicus
100520167 Sus scrofa
538371 Bos taurus
18507 Mus musculus
60636 Danio rerio
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