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Paired Box 6 Proteins (PAX6)

PAX6 encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. Additionally we are shipping PAX6 Antibodies (238) and PAX6 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PAX6 25509 P63016
PAX6 5080 P26367
PAX6 18508 P63015
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Top PAX6 Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,535.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,175.33
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,175.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,175.33
Details
Yeast Oryzias latipes His tag   1 mg Log in to see 56 to 66 Days
$3,223.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

PAX6 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,
,
Mouse (Murine)

Top referenced PAX6 Proteins

  1. Human PAX6 Protein expressed in Wheat germ - ABIN1314075 : Maucksch, Firmin, Butler-Munro, Montgomery, Dottori, Connor: Non-Viral Generation of Neural Precursor-like Cells from Adult Human Fibroblasts. in Journal of stem cells & regenerative medicine 2014 (PubMed)

More Proteins for Paired Box 6 (PAX6) Interaction Partners

Xenopus laevis Paired Box 6 (PAX6) interaction partners

  1. signaling via Pax6 expression through Shp2-binding sites of XFrs3 is necessary for the eye development in Xenopus laevis

  2. Our results show that the expression of Pax6 and Pax7 (show PAX7 Proteins) is widely maintained in the adult brain of Xenopus

Human Paired Box 6 (PAX6) interaction partners

  1. findings suggest that PAX6+/- is associated with smaller pineal size, lower melatonin secretion and greater parental report of sleep disturbances in children; further studies are needed to explore the potential use of melatonin replacement for improving sleep quality in patients with PAX6+/-

  2. In post-mortem substantia nigra from Parkinson's disease patients, a reduced number of PAX6 expressing cells were found.

  3. We analyzed the PAX6 gene in a Bosma arrhinia microphthalmia syndrome patient but found no variation or mutation that could constitute or establish a causal association in our patient

  4. Variants in TRIM44 (show TRIM44 Proteins) Cause Aniridia by Impairing PAX6 Expression

  5. MicroRNA-7 inhibits the malignant phenotypes of nonsmall cell lung cancer in vitro by targeting Pax6

  6. ChIP experiments confirmed that Pdx1 (show PDX1 Proteins) activates the expression of the downstream transcription factors, Ngn3 (show NEUROG3 Proteins) and Pax6, by combined with the promoter regions of insulin (Insulin (show INS Proteins)-P), Ngn3 (Ngn3 (show NEUROG3 Proteins)-P), and Pax6 (Pax6-P).

  7. we reported the results of the clinical and molecular evaluation of a threegeneration Chinese family with aniridia and identified a rare heterozygous M1K mutation in PAX6.

  8. Trans-placental BPA (show DST Proteins) exposure down-regulated gene expression of Sox2 (show SOX2 Proteins) and Pax6 potentially underlying the adverse effect on childhood neuronal development. [Meta-analysis]

  9. Molecular analysis identified two compound heterozygous TYR (show TYR Proteins) mutations known to cause OCAIA (show TYR Proteins) and cosegregate with oculocutaneous albinism. In addition, we identified a novel heterozygous PAX6 mutation confirming the atypical aniridia phenotype.

  10. SOX4, SOX11 (show SOX11 Proteins), and PAX6 were significant for tumor type.

Cow (Bovine) Paired Box 6 (PAX6) interaction partners

  1. Some polymorphisms in PAX6 are associated with growth traits at some ages, and may be used as candidates for marker-assisted selection in beef cattle breeding program.

Mouse (Murine) Paired Box 6 (PAX6) interaction partners

  1. c.718C>T transitional mutation of PAX6 has been found to underlie the aniridia, which showed an autosomal dominant inheritance pattern in this northeastern Chinese family

  2. novel mutation in the PAX6 gene has been identified in a Chinese family affected with aniridia

  3. the Pax6 paired domain has roles in neural tube patterning and peripheral nervous system development

  4. This study demonstrated that Pax6 is expressed in astrocytes and binds to the GLT-1 promoter in vitro and in vivo.

  5. Pax6 inactivation in the adult pancreas reveals ghrelin (show GHRL Proteins) as endocrine cell maturation marker.

  6. results indicate that Pax6 is required by thalamic progenitors for the normal molecular patterning of the thalamic neurons that they generate

  7. Pax6 expression is essential for horizontal basal cells to differentiate into neuronal cells during regeneration.

  8. Upper-layer neuron production was increased in double-transgenic mouse embryos with sustained Pax6 expression in the neurogenic lineage. Increased basal progenitors existed in the subventricular zone and the intermediate zone of the neocortex.

  9. NFIA (show NFIA Proteins) and NFIB (show NFIB Proteins) are endogenously expressed in gradients with high caudo-medial to low rostro-lateral expression ... this expression pattern deviates from that of PAX6, suggesting that PAX6 does not drive Nfi (show NFIC Proteins) expression

  10. The expression dynamics shows that Pax6 localizes at XY body during meiotic prophase I, especially in the mid-phase of pachytene spermatocytes which suggests that Pax6 may have some function in inactivation of sex chromosomes during meiosis.

Zebrafish Paired Box 6 (PAX6) interaction partners

  1. Pax6 has an evolutionarily conserved function in establishing the temporospatial expression of Shh (show SHH Proteins) in the mid-diencephalic organizer in vertebrates.

  2. loss of Pax6b or Hb9 (show MNX1 Proteins) independently results in the loss of insulin (show INS Proteins) expression, the data reveal a novel cross-talk between the two essential regulators of early beta-cell differentiation.

  3. The results suggest that decreased Pax6 expression is permissive for axon regeneration and extensive searching, while higher levels of Pax6 are associated with restoration of topography.

  4. This study supports the hypothesis that the Pax6 transcription factor is also a signaling molecule with direct non-cell autonomous activity.

  5. following a postulated whole-genome duplication event in an ancestral teleost, duplicates pax6a and pax6b encode transcription factors required for eye, brain, olfactory system, and pancreas development

  6. Pax6 interacts with itself via both the paired domain and the homeodomain. Pax6 interaction with itself superactivates Pax6 mediated transactivation.

PAX6 Protein Profile

Protein Summary

This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with Paired Box 6 Proteins (PAX6)

  • paired box 6 (PAX6)
  • paired box 6 (pax6)
  • paired box 6 (Pax6)
  • paired box 6 (pax6-a)
  • paired box 6 (pax6-b)
  • paired box gene 6 (Pax6)
  • paired box gene 6a (pax6a)
  • 1500038E17Rik protein
  • AEY11 protein
  • AN protein
  • AN2 protein
  • cb280 protein
  • D11S812E protein
  • Dey protein
  • fc20e07 protein
  • Gsfaey11 protein
  • MGC52531 protein
  • MGDA protein
  • Pax-6 protein
  • pax-a protein
  • pax6 protein
  • Pax6.1 protein
  • pax6a protein
  • pax6b protein
  • PAXZF-A protein
  • paxzfa protein
  • pax[zf-a] protein
  • Sey protein
  • WAGR protein
  • wu:fc20e07 protein
  • XLPAX6 protein
  • xpax6 protein
  • zfpax-6a protein
  • zfpax-6b protein

Protein level used designations for Paired Box 6 Proteins (PAX6)

paired box protein Pax-6 , paired box 6 , paired box gene 6 , oculorhombin , paired box homeotic gene 6 , paired box gene 6 a , aniridia type II protein , paired box homeotic gene-6 , paired box gene 6 (aniridia, keratitis) , paired box protein PAX6 , paired box gene 6 b , paired domain transcription factor variant B , paired-type homeodomain Pax-6 protein , Dickie's small eye , small eye , etID309716.25 , paired box protein Pax[Zf-a] , pax-6

GENE ID SPECIES
100146390 Equus caballus
695746 Macaca mulatta
100303503 Saccoglossus kowalevskii
100552301 Anolis carolinensis
100590220 Nomascus leucogenys
554264 Ovis aries
25509 Rattus norvegicus
379100 Xenopus laevis
395943 Gallus gallus
5080 Homo sapiens
483441 Canis lupus familiaris
286857 Bos taurus
100009018 Oryctolagus cuniculus
100337586 Xenopus laevis
18508 Mus musculus
30567 Danio rerio
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