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PAX9 is a member of the paired box (PAX) family of transcription factors. Additionally we are shipping PAX9 Antibodies (84) and PAX9 Kits (2) and many more products for this protein.
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The phenotypes caused by the knockdown of Pax1b in zebrafish could not be phenocopied by pax9 morphilino and could not be rescued by either Pax1a or Pax9 overexpression.
Functional investigation of a subset of these genes, fgf10a (show FGF10 Proteins), tgfb2 (show TGFB2 Proteins), pax9, and smad5 (show SMAD5 Proteins) revealed their necessity in zebrafish palatogenesis.
Cloning and examination through whole-mount in situ hybridization and reverse transcriptase-polymerase chain reaction of the expression patterns of pax1, pax9, and uncx transcription factors in the anuran Xenopus laevis.
Statistically significant relations were found between detected 22 variations in PAX9 gene and tooth size and were detected in which 18 of them are novel.
results demonstrate a new initiation codon mutation in the PAX9 gene; this mutation probably caused the oligodontia in the investigated Chinese family through haplo-insufficiency
previously unknown heterozygous g.9527G>T mutation in the PAX9 gene in monozygotic twins with oligodontia & 3 additional affected family members. mutation is located in intron 2, splice site between exon 2 and intron 2.
analysis provided evidence for gene-gene interaction between FGF3 (show FGF3 Proteins) (rs4980700) and PAX9 (rs2073242), increasing risk for isolated oral clefts (p = 0.0003). FGF3 (show FGF3 Proteins) is associated with oral clefts and may interact with PAX9.
The meta-analysis results revealed 4 genetic sites of the PAX9 gene involved in hypodontia cases.
Probably other genes can determine phenotypical patterns of dental agenesis in the families studied, different than the ones described in the mutations of PAX9
Polymorphisms in the promoter region of PAX9 gene may have an influence on the transcriptional factors and activity of this gene.
Significant association was demonstrated between genotypic distribution of SNPs in the MSX1 (show MSX1 Proteins) and PAX9 genes and tooth agenesis type (TAT (show TAT Proteins)) in Korean patients with nonsyndromic cleft lip and palate.
Identification of novel mutations in the paired domain of PAX9 in two unrelated Japanese patients with sporadic non-syndromic oligodontia.
Combined reduction of MSX1 (show MSX1 Proteins) and PAX9 gene dosages increased the risk for oligodontia in Mexican families.
The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells. A primary function for Pax9 in the expansion of taste progenitor fields in taste papillae.
Transfection of Pax9 and Bmp4 (show BMP4 Proteins) into mouse induced pluripotent stem cells facilitates their differentiation into odontoblast-like cells for cell- and tissue-based therapy.
Disruption of Slc25a21 (show Slc25a21 Proteins) is associated with orofacial defects and otitis media due to diminished expression of a neighboring gene, pax9.
Our data indicate that Pax9 regulates a molecular network involving the Bmp4, Fgf10, Shh and Osr2 pathways to control palatal shelf patterning and morphogenesis.
the transcription factors Pax3 (show PAX3 Proteins) and Pax9 as redundant regulators of mouse heterochromatin, as they repress RNA output from major satellite repeats by associating with DNA within pericentric heterochromatin
Mice lacking both Osr2 and Pax9 exhibited early tooth developmental arrest with significantly reduced Bmp4 (show BMP4 Proteins) and Msx1 (show MSX1 Proteins) mRNA expression in the developing tooth mesenchyme.
Genetic interactions between Pax9 and Msx1 (show MSX1 Proteins) regulate lip development and several stages of tooth morphogenesis.
Thymopoiesis requires Pax9 function in thymic epithelial cells. In Pax9 null mice, the thymic anlage develops as an ectopic polyp-like structure in the larynx, fails to perform the normal caudo-ventral movement to the upper mediastinum, and remains small.
Pax1 (show PAX1 Proteins) and Pax9 can transactivate regulatory sequences in the Bapx1 (show NKX3-2 Proteins) promoter to induce chondrogenic differentiation in the sclerotome.
PAX9 has a role in tooth development in humans
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 9 gene is unknown but it may involve development of stratified squamous epithelia as well as various organs and skeletal elements.
, paired box homeotic gene 9
, paired box protein Pax-9
, paired box 9
, paired box gene 9
, paired box protein Pax-9-like
, paired domain gene 9
, Paired box protein Pax-9