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PAX8 encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain.
PAX8 protein expression was associated with germinal layers in human and murine forebrain and hindbrain development.
Pax8 is essential for function and survival of adult thyroid cells.
a core regulatory subcircuit composed of Pax2 (show PAX2 ELISA Kits)/8, Gata3 (show GATA3 ELISA Kits) and Lim1 (show LHX1 ELISA Kits) turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
The Pax8 promoter appears to be autoregulated, a feature that might be responsible for the haploinsufficiency displayed by this gene.
Inducible, Pax8-rtTA-based deletion of VHL (show VHL ELISA Kits) leads to organ-specific expression of epithelial HIF and erythropoietin (show EPO ELISA Kits) in liver and kidney without causing pathological changes.
study concludes that Cadherin-16 is a novel downstream target of the transcription factor Pax8, likely since the early steps of thyroid development, and that its expression is associated with the fully differentiated state of the thyroid cell
a thyroid-specific regulatory element in the 5' upstream region of the Pax8 gene
these data identify Pax2 (show PAX2 ELISA Kits) and Pax8 as critical regulators that specify the nephric lineage.
The Box protein Pax-8 gene is an important and cardiac-specific ALK3 downstream gene in the BMP signaling pathway during inter-ventricular septum development.
Pax8(-/-)TRalpha1(-/-) compound mutants die around weaning unless they are substituted with thyroid hormones. Short life span of Pax8(-/-) mice due to complex mechanism involving TRalpha2 and an unliganded TR isoform.
This gene encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain. The encoded protein is important for proper differentiation of the thyroid and the kidney. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
paired box protein Pax-8
, Pax-8 protein
, paired box gene 8