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Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain (By similarity)..
The findings provide evidence for a putative novel role of PIN1 in the development of the nociceptive system and indicate phosphorylation-mediated conformational changes as a mechanism for regulating the PRRXL1 role in the process.
The results of this study suggest that Prrxl1 knockout mouse model of congenital hypoalgesia may have an effect on brain plasticity that is the inverse of what is usually observed in animal models of chronic pain.
The results of this study showed that Prrxl1(-/-) animal is a valuable model system for examining the genetic assembly and functional role of trigeminal lemniscal circuits in the normal control of eating in mammals.
Tlx3 uses distinct mechanisms to tightly modulate Prrxl1 activity, either by controlling its transcriptional levels or by increasing Prrxl1 phosphorylation state.
Prrxl1 uses distinct regulatory regions to repress its own expression in dorsal root ganglia and dorsal spinal cord.
Data suggest phosphorylation at serine-119 is a determinant of Prrxl1 conformation/transcriptional activity in embryonic dorsal root ganglia and dorsal spinal cord nociceptive neurons and may regulate Prrxl1 during nociceptive system development.
Prrxl1 transcription is regulated by three alternative promoters, which control the expression of three distinct Prrxl1 5'-UTR (show UTS2R ELISA Kits) variants.
Our present results point to a role for Prrxl1 in sensitization of nociceptive neurons upon inflammatory pain.
Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires Drg11.
transcriptionally regulates DRAGON; coexpressed with DRAGON in embryonic dorsal root ganglion and spinal cord
Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain (By similarity).
dorsal root ganglia homeobox protein
, paired related homeobox-like 1
, paired-like homeodomain trancription factor DRG11
, dorsal root ganglion 11
, homeobox protein DRG11
, paired related homeobox protein-like 1
, paired-like homeodomain trancription factor Drg11
, paired-related homeobox protein-like 1
, paired homeodomain protein DRG11
, paired related homeobox protein-like 1b