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The DNA-associated protein encoded by PHOX2B is a member of the paired family of homeobox proteins localized to the nucleus. Additionally we are shipping PHOX2B Proteins (2) and many more products for this protein.
Showing 10 out of 54 products:
Human Polyclonal PHOX2B Primary Antibody for ELISA - ABIN449850
McGaughey, Vinton, Huynh, Al-Saif, Beer, McCallion: Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b. in Genome research 2008
Mouse (Murine) Polyclonal PHOX2B Primary Antibody for IF, WB - ABIN655288
Burbach, Hellemons, Grant, Pant: The homeodomain transcription factor Phox2 in the stellate ganglion of the squid Loligo pealei. in Biology open 2015
reduced dosage of PHOX2B during development, through either a heterozygous deletion or dominant-negative mutation, imposes a block in the differentiation of sympathetic neuronal precursors
Phox2b is expressed throughout the primary taste centers of two cyprinid fish, Danio rerio and Carassius auratus
Phox2b function is sox10 (show SOX10 Antibodies)-dependent in the developing enteric nervous system
Given the association between congenital heart disease and aberrant neural crest cell development, however, findings are suggestive that congenital heart disease may be a rare feature of PHOX2B mutation which has not been previously reported
This study is the first to evaluate minimal residual disease detection using neuroblastoma (show ARHGEF16 Antibodies) mRNAs in human ovarian tissue. Only PHOX2B was a reliable marker of neuroblastoma (show ARHGEF16 Antibodies) cells contaminating ovarian tissue.
This truncated protein localized to the nucleus and transactivated a target promoter. These data suggest that nonsense pathogenic variants in the first exon of PHOX2B likely escape nonsense mediated decay (NMD) and produce N-terminally truncated proteins functionally distinct from those produced by the more common polyalanine repeat mutations (PARMs).
These pre-clinical data strongly suggest that PHOX2B functions as a suppressor of neuroblastoma (show ARHGEF16 Antibodies) progression.
High PHOX2B expression is associated with Neuroblastoma (show ARHGEF16 Antibodies).
PHOX2B forms homodimers and heterodimerizes weakly with mutated proteins, excluding the direct involvement of the polyalanine tract in dimer formation, indicating that mutated proteins retain partial ability to form heterodimers with PHOX2A (show PHOX2A Antibodies).
Expression of NOX4 (show NOX4 Antibodies)/p22(phox (show CYBA Antibodies)) as well as ROS (show ROS1 Antibodies) production is enhanced by IL-1beta (show IL1B Antibodies). On the other hand, the use of NOX4 (show NOX4 Antibodies) inhibitors decreased IL-1beta (show IL1B Antibodies)-induced collagenase synthesis by chondrocytes.
PHOX2A (show PHOX2A Antibodies) expression is finely controlled during retinoic acid differentiation and this, together with PHOX2B down-regulation.
Point "silent" mutations affecting different nucleotides of the PHOX2B gene were observed in 32 % of patients with Class III malocclusion and never in controls (0 %).
Germline non-polyalanine repeat expansion mutations in PHOX2B (PHOX2B NPARM) predispose to peripheral neuroblastic tumors (PNT (show ETS2 Antibodies)), frequently in association with other neurocristopathies.
Murine models of congenital central hypoventilation syndrome designed with PHOX2B mutations have suggested RTN neuron agenesis.
The retrotrapezoid nucleus neurons expressing Atoh1 (show ATOH1 Antibodies) and Phox2b are essential for the respiratory response to CO2.
Adult Phox2b(+/-) mice showed altered exploratory behavior in the open field and in the elevated plus maze, both indicative of anxiety. Phox2b(+/-) mice did not show cognitive or motor impairments.
many cranial nerve-associated crest cells coexpress the pan (show SUPT6H Antibodies)-autonomic determinant Paired-like homeodomain 2b (Phox2b) together with markers of Schwann cell precursors. Some give rise to Schwann cells after down-regulation of PHOX2b.
In this review, conditional mouse mutants of Phox2b(27Ala) lacked the ventilary response to hypercapnia at birth.
Phox2b transcripts were identified in FAC (show FANCC Antibodies)-sorted Pitx3 (show PITX3 Antibodies) positive neurons.
This study demonistrated that Phox2b-expressing retrotrapezoid neurons are intrinsically responsive to H+ and CO2.
Nonpolyalanine repeat expansion mutation of PHOX2B is both a dominant-negative and gain-of-function mutation.
The PHOX2B can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching.
The cranial sensory pathways, somatic and visceral, are related, and Phox2b serves as a developmental switch from the former to the latter.
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.
paired-like homeobox 2b
, paired mesoderm homeobox protein 2B
, PHOX2B homeodomain protein
, neuroblastoma Phox
, neuroblastoma paired-type homeobox protein
, paired mesoderm homeobox 2b
, GENA 269
, dilated pupils 1