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anti-Palmitoyl-Protein Thioesterase 1 (PPT1) Antibodies

The protein encoded by PPT1 is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. Additionally we are shipping PPT1 Proteins (12) and PPT1 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PPT1 5538 P50897
PPT1 19063 O88531
PPT1 29411 P45479
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Top anti-PPT1 Antibodies at antibodies-online.com

Showing 10 out of 89 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated WB 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of PPT1 Antibody (C-term) (ABIN389117) in 293 cell line lysates (35 µg/lane). PPT1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PPT1 antibody (C-term) (ABIN389117), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of hPPT1-C46 (ABIN389116) in mouse cerebellum tissue lysates (35 µg/lane).PPT1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB PPT1 Antibody (Center)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PPT1 antibody detected the PPT1 protein (arrow). Western blot analysis of PPT1 (arrow) using rabbit polyclonal PPT1 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PPT1 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$529.83
Details

PPT1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
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Top referenced anti-PPT1 Antibodies

  1. Human Polyclonal PPT1 Primary Antibody for EIA, IHC (p) - ABIN357783 : Calero, Gupta, Nonato, Tandel, Biehl, Hofmann, Clardy: The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN357783

  2. Human Polyclonal PPT1 Primary Antibody for EIA, IHC (p) - ABIN357784 : Hofmann, Atashband, Cho, Das, Gupta, Lu: Neuronal ceroid lipofuscinoses caused by defects in soluble lysosomal enzymes (CLN1 and CLN2). in Current molecular medicine 2002 (PubMed)
    Show all 5 references for ABIN357784

  3. Human Monoclonal PPT1 Primary Antibody for WB - ABIN1944801 : Crews, Lane, Schreiber: Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 4 references for ABIN1944801

More Antibodies against PPT1 Interaction Partners

Human Palmitoyl-Protein Thioesterase 1 (PPT1) interaction partners

  1. we reveal the existence of a positive feedback loop, where palmitoylation of PPT1 results in decreased activity and subsequent elevation in the amount of palmitoylated proteins.

  2. analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma (show ARHGEF16 Antibodies) cells

  3. Data (including data from knockout mice) suggest that deficiency of PPT1 leads to accumulation of granular osmiophilic deposits in many cell types, especially in astrocytes. [review-like article]

  4. Data suggest that human monocytes and macrophages express PPT1; PPT1 appears to contribute 32-40% of 2-arachidonylglycerol hydrolysis activity in THP1 monocyte cell line.

  5. This neuroimaging finding in PPT1-related neuronal ceroid lipofuscinosis (show CLN6 Antibodies) was not previously reported.

  6. Stop codon read-through with PTC124 induces palmitoyl-protein thioesterase-1 activity, reduces thioester load and suppresses apoptosis in cultured cells from Infantile neuronal ceroid lipofuscinosis (show CLN6 Antibodies) patients.

  7. Results describe the correlation between the three-dimensional structural changes in mutant palmitoyl protein thioesterase 1 and biochemical phenotypes.

  8. mutated in neuronal ceroid lipofuscinosis (show CLN6 Antibodies)

  9. The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2.

  10. there is a close correlation between CLN2 (show TPP1 Antibodies) and CLN1 expression and colorectal carcinoma progression and metastasis and suggest that they may be potential molecular targets

Mouse (Murine) Palmitoyl-Protein Thioesterase 1 (PPT1) interaction partners

  1. Parkinson-like motor/sensorimotor deficits in Cln1-/- mice are not mediated by dopamine deficiency.

  2. Data show that Cln1 mutations disrupt the maturation of cathepsin D (show CTSD Antibodies) in lysosome contributing to neuropathology of infantile neuronal ceroid lipofuscinoses and suggest cathepsin D (show CTSD Antibodies) deficiency to be common link between infantile and congenital form.

  3. The authors have generated a Cln1 R151X point mutation mouse model that recapitulates the molecular, neuropathological and behavioral phenotypes of neuronal ceroid lipofuscinoses.

  4. Data (including data from knockout mice) suggest that deficiency of Ppt1 leads to accumulation of granular osmiophilic deposits in many cell types, especially in astrocytes. [review-like article]

  5. Data suggest that mouse macrophages express PPT1; PPT1 appears to contribute to 2-arachidonylglycerol hydrolysis activity in peritoneal macrophages in culture.

  6. The simultaneous loss of both Cln1 and Cln5 (show CLN5 Antibodies) genes might enhance the typical pathological phenotypes of these mice by disrupting or downregulating shared or convergent pathogenic pathways.

  7. These results uncover a previously unknown phenotype associated with PPT1 deficiency, that of altered thermoregulation, which is associated with impaired lipolysis and neurotransmitter release to brown adipose tissue during cold exposure.

  8. The addition of the small molecule PPT1 mimetic can further increase that response.

  9. Glutamate receptor 4 (GluR4 (show GRIA4 Antibodies)) AMPA (show GRIA3 Antibodies) receptor hypofunction and NMDA receptor hyperfunction phenotype show increased sensitivity in Ppt1-deficient neurons.

  10. Data show a progressive breakdown of axons and synapses in the brains of two different models of NCL (show NCL Antibodies): Ppt1(-/-) model of infantile NCL (show NCL Antibodies) and Cln6(nclf (show CLN6 Antibodies)) model of variant late-infantile NCL (show NCL Antibodies).

PPT1 Antigen Profile

Protein Summary

The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PPT1

  • palmitoyl-protein thioesterase 1 (MGYG_00692) antibody
  • palmitoyl-protein thioesterase 1 (PPT1) antibody
  • palmitoyl-protein thioesterase 1 (Ppt1) antibody
  • Protein PPT-1 (ppt-1) antibody
  • similar to palmitoyl-protein thioesterase (RGD1560700) antibody
  • 9530043G02Rik antibody
  • AA960502 antibody
  • C77813 antibody
  • CLN1 antibody
  • D4Ertd184e antibody
  • INCL antibody
  • Ppt antibody

Protein level used designations for PPT1

palmitoyl-protein thioesterase 1 , ceroid-palmitoyl-palmitoyl-protein thioesterase 1 , palmitoyl-protein hydrolase 1 , PPT-1 , palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) , palmitoyl protein thioesterase

GENE ID SPECIES
10031925 Arthroderma gypseum CBS 118893
5538 Homo sapiens
19063 Mus musculus
29411 Rattus norvegicus
419681 Gallus gallus
475316 Canis lupus familiaris
281421 Bos taurus
191744 Caenorhabditis elegans
362585 Rattus norvegicus
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