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Palmitoyl-Protein Thioesterase 1 Proteins (PPT1)

The protein encoded by PPT1 is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. Additionally we are shipping PPT1 Antibodies (87) and PPT1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPT1 5538 P50897
PPT1 19063 O88531
PPT1 29411 P45479
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Top PPT1 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,731.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,731.67
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,731.67
Details
Yeast Caenorhabditis elegans His tag   1 mg Log in to see 56 to 66 Days
$2,740.83
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$160.55
Details

PPT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)
,
Rat (Rattus)

More Proteins for Palmitoyl-Protein Thioesterase 1 (PPT1) Interaction Partners

Human Palmitoyl-Protein Thioesterase 1 (PPT1) interaction partners

  1. we reveal the existence of a positive feedback loop, where palmitoylation of PPT1 results in decreased activity and subsequent elevation in the amount of palmitoylated proteins.

  2. analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma (show ARHGEF16 Proteins) cells

  3. Data (including data from knockout mice) suggest that deficiency of PPT1 leads to accumulation of granular osmiophilic deposits in many cell types, especially in astrocytes. [review-like article]

  4. Data suggest that human monocytes and macrophages express PPT1; PPT1 appears to contribute 32-40% of 2-arachidonylglycerol hydrolysis activity in THP1 monocyte cell line.

  5. This neuroimaging finding in PPT1-related neuronal ceroid lipofuscinosis (show CLN6 Proteins) was not previously reported.

  6. Stop codon read-through with PTC124 induces palmitoyl-protein thioesterase-1 activity, reduces thioester load and suppresses apoptosis in cultured cells from Infantile neuronal ceroid lipofuscinosis (show CLN6 Proteins) patients.

  7. Results describe the correlation between the three-dimensional structural changes in mutant palmitoyl protein thioesterase 1 and biochemical phenotypes.

  8. mutated in neuronal ceroid lipofuscinosis (show CLN6 Proteins)

  9. The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2.

  10. there is a close correlation between CLN2 (show TPP1 Proteins) and CLN1 expression and colorectal carcinoma progression and metastasis and suggest that they may be potential molecular targets

Mouse (Murine) Palmitoyl-Protein Thioesterase 1 (PPT1) interaction partners

  1. Parkinson-like motor/sensorimotor deficits in Cln1-/- mice are not mediated by dopamine deficiency.

  2. Data show that Cln1 mutations disrupt the maturation of cathepsin D (show CTSD Proteins) in lysosome contributing to neuropathology of infantile neuronal ceroid lipofuscinoses and suggest cathepsin D (show CTSD Proteins) deficiency to be common link between infantile and congenital form.

  3. The authors have generated a Cln1 R151X point mutation mouse model that recapitulates the molecular, neuropathological and behavioral phenotypes of neuronal ceroid lipofuscinoses.

  4. Data (including data from knockout mice) suggest that deficiency of Ppt1 leads to accumulation of granular osmiophilic deposits in many cell types, especially in astrocytes. [review-like article]

  5. Data suggest that mouse macrophages express PPT1; PPT1 appears to contribute to 2-arachidonylglycerol hydrolysis activity in peritoneal macrophages in culture.

  6. The simultaneous loss of both Cln1 and Cln5 (show CLN5 Proteins) genes might enhance the typical pathological phenotypes of these mice by disrupting or downregulating shared or convergent pathogenic pathways.

  7. These results uncover a previously unknown phenotype associated with PPT1 deficiency, that of altered thermoregulation, which is associated with impaired lipolysis and neurotransmitter release to brown adipose tissue during cold exposure.

  8. The addition of the small molecule PPT1 mimetic can further increase that response.

  9. Glutamate receptor 4 (GluR4 (show GRIA4 Proteins)) AMPA (show GRIA3 Proteins) receptor hypofunction and NMDA receptor hyperfunction phenotype show increased sensitivity in Ppt1-deficient neurons.

  10. Data show a progressive breakdown of axons and synapses in the brains of two different models of NCL (show NCL Proteins): Ppt1(-/-) model of infantile NCL (show NCL Proteins) and Cln6(nclf (show CLN6 Proteins)) model of variant late-infantile NCL (show NCL Proteins).

PPT1 Protein Profile

Protein Summary

The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PPT1

  • palmitoyl-protein thioesterase 1 (MGYG_00692)
  • palmitoyl-protein thioesterase 1 (PPT1)
  • palmitoyl-protein thioesterase 1 (Ppt1)
  • Protein PPT-1 (ppt-1)
  • similar to palmitoyl-protein thioesterase (RGD1560700)
  • 9530043G02Rik protein
  • AA960502 protein
  • C77813 protein
  • CLN1 protein
  • D4Ertd184e protein
  • INCL protein
  • Ppt protein

Protein level used designations for PPT1

palmitoyl-protein thioesterase 1 , ceroid-palmitoyl-palmitoyl-protein thioesterase 1 , palmitoyl-protein hydrolase 1 , PPT-1 , palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) , palmitoyl protein thioesterase

GENE ID SPECIES
10031925 Arthroderma gypseum CBS 118893
5538 Homo sapiens
19063 Mus musculus
29411 Rattus norvegicus
419681 Gallus gallus
475316 Canis lupus familiaris
281421 Bos taurus
191744 Caenorhabditis elegans
362585 Rattus norvegicus
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