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high affinity receptor for pancreatic polypeptide that inhibits gall bladder contraction, gut motility, and pancreatic secretion [RGD, Feb 2006]..
Results suggest that rabbit and human Y1, Y2 and Y5 receptor (show NPY5R Proteins) subtypes are well conserved, whereas Y4 receptors are less well conserved.
A copy number variation (CNV) analysis demonstrated a significantly higher frequency of NPY4R containing 10q11.22 CNV loss in the patient population, while CNV gain in this region was more prevalent in the control population. Mutation analysis resulted in the identification of 15 rare non-synonymous heterozygous variants. Two variants in the patient population demonstrated receptor dysfunction and a pathogenic effect.
Data suggest that repression of JNK-c-Jun signaling through pancreatic polypeptide receptor 1 (PP1) is one of the key anti-tumor mechanisms of neuronal membrane cytoskeletal protein 4.1 (show EPB41 Proteins) (4.1N (show EPB41L1 Proteins)).
These data demonstrate glucose-regulated secretion of PP and its effects on glucagon (show GCG Proteins) release through PPYR1 receptors expressed by alpha-cells.
Pancreatic polypeptide (show PPY Proteins) is recognized by two hydrophobic domains of the human Y4 receptor binding pocket.
structure determination of transmembrane segments of Y4 and the yeast Ste2p G-protein-coupled receptors
Results report on the functional reconstitution of the hY(2)R and the hY(4 (show CRY1 Proteins))R in Sf9 insect cells using the baculovirus system.
The pharmacologic insensitivity of pancreatic polypeptide responses to either NPY1- or NPY2-receptor antagonism, or to tetrodotoxin, indicates that NPY4 receptors are involved and that they are predominantly post-junctional in colon mucosa.
PP1 (show PPA1 Proteins) is targeted to DNA polymerase (show POLB Proteins) III via an interaction with the p68 (show ANXA6 Proteins) subunit.
Genetic deletion of the Y4 receptor impaired fear extinction, an effect that was rescued by short-term fasting
Data describe the complex interaction between Y2/Y4 receptors in control of bone mass, and suggest that the reduction in cortical bone observed in the absence of leptin (show LEP Proteins) is due to the anti-osteogenic effect of elevated hypothalamic NPY (show NPY Proteins) levels.
Data from studies in knockout mice suggest that signaling through Y4 receptor prevents development of short-/long-term anxiety-/depression-like behaviour caused by acute immune challenge. Study includes comparison with Y2 receptor (show NPY2R Proteins) knockout mice.
Pancreatic polypeptide (show PPY Proteins) enhances colonic contractile activity and fecal output through neuropeptide Y (show NPY Proteins) Y(4) receptor, and a neuropeptide Y (show NPY Proteins) Y(4) receptor agonist might offer a novel therapeutic approach to ameliorate constipation.
These findings show that pancreatic polypeptide (show PPY Proteins) reduces food intake predominantly via stimulation of the anorexigenic alpha-MSH signaling pathway, and that this effect is mediated by direct action on local Y4 receptors within the arcuate nucleus.
These findings attest to a differential role of Y2 and Y4 receptor signalling in the circadian control of behaviours that balance energy intake and energy expenditure.
Y1, Y2, and Y4 receptors are not crucially involved in NPY's hyperphagic, hypogonadal (show GNRH1 Proteins), and obesogenic effects, but they are responsible for the central regulation of circulating insulin (show INS Proteins) levels by NPY (show NPY Proteins).
The neuropeptide Y (NPY (show NPY Proteins))-Y4 receptor knockout mice Increased novelty-induced motor activity and reduced depression-like behavior.
high affinity receptor for pancreatic polypeptide that inhibits gall bladder contraction, gut motility, and pancreatic secretion
gastric Y4 receptor
, neuropeptide Y receptor Y4
, neuropeptide Y receptor type 4
, G-protein coupled receptor
, neuropeptide Y receptor 4
, pancreatic polypeptide receptor 1
, neuropeptide Y receptor type 4-like
, Y4 receptor