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The protein encoded by PANX1 belongs to the innexin family. Additionally we are shipping Pannexin 1 Antibodies (51) and Pannexin 1 Kits (7) and many more products for this protein.
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Extracellular ATP hydrolysis via NTPDase1 (show ENTPD1 Proteins) action inhibits synaptic transmission by pannexin 1-mediated increase in pH buffering of the synaptic cleft.
The existence of two Panx1 proteins in zebrafish displaying distinct tissue distribution, protein modification and electrophysiological properties, suggests that both proteins fulfill different functions in vivo.
The function of panx1 channel is significantly reduced following mutation of a single cysteine residue (C282W) in the fourth transmembrane region of panx1.
Overactive Panx-1 promotes cancer cell survival in the context of mechanical deformation. Panx-1 inhibitors can be used to treat highly metastatic cancer. Mechanosensitive Panx-1 channels will be a new target for the prevention of metastasis and stress-induced diseases.
The results of this study do not support a major contribution of PANX1-3 to disease risk of schizophrenia according to DSM-5.
a pivotal role of P2X7 receptor (show P2RX7 Proteins)-pannexin-1 in oxysterols toxicity in retinal cells
Data indicate that the consanguineous parents are each heterozygous for Pannexin1 (PANX1) but are not affected by the multiorgan syndromes.
CBX (show CBX1 Proteins) and other inhibitors, including probenecid, attenuate Panx1 channel activity through modulation of the first extracellular loop.
Decreased Panx1 function is a response to cell acidification mediated by IFN-gamma-induced (show SAMHD1 Proteins) up-regulation of Duox2 (show DUOX2 Proteins).
PANX-1 plays an important role in the release of cytokines and glutamate (show GRIN1 Proteins) in a tumor cell line.
The frequency of Panx1-400C homozygotes was higher among cardiovascular patients with hyper-reactive platelets. The Panx1-400C variant encodes a gain-of-function channel that enhances collagen-induced ATP release and platelet aggregation.
Pannexin1-dependent pathophysiological eATP release in lipoapoptosis is capable of stimulating migration of human monocytes
Panx1 channels promote leukocyte adhesion and emigration through the venous wall during acute systemic inflammation.
These results indicate that activation of Panx1 and P2X7 (show P2RX7 Proteins) R are required for apoptotic osteocytes in fatigued bone to trigger RANKL (show TNFSF11 Proteins) production in neighboring bystander osteocytes and implicate ATP as an essential signal mediating this process.
Panx1 is expressed in the central and peripheral nervous system during early developmental stages.
this study provides the first demonstration of Panx1 channel morphology and assembly in intact cells.
Panx1 in the heart influences different electrophysiological parameters involving depolarization, repolarization and atrial vulnerability causing atrial fibrillation.
ATP released by myocardial cells through Pannexin-1 channel during ischemia could evoke calcium responses in cardiac sympathetic nerve fibers.
Platelets of Panx1-/- mice showed reduced collagen-induced aggregation as compared to those of WT mice.
The observations of this study reveal a new role for Panx1 in NPC (show NPC1 Proteins) maintenance in the VZ and suggesting that targeting peri (show POSTN Proteins)-infarct Panx1 (in combination with other interventions) could improve outcomes after stroke.
The role of Pannexin 1 is analyzed at the systems level, it is not required for normal taste perception. Further studies are needed to determine the role of this hemichannel in taste cells.
The PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.