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Pannexin 1 Proteins (PANX1)

The protein encoded by PANX1 belongs to the innexin family. Additionally we are shipping Pannexin 1 Antibodies (51) and Pannexin 1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PANX1 24145 Q96RD7
PANX1 55991 Q9JIP4
PANX1 315435 P60570
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Top Pannexin 1 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$838.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details

PANX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Pannexin 1 (PANX1) Interaction Partners

Zebrafish Pannexin 1 (PANX1) interaction partners

  1. Extracellular ATP hydrolysis via NTPDase1 (show ENTPD1 Proteins) action inhibits synaptic transmission by pannexin 1-mediated increase in pH buffering of the synaptic cleft.

  2. The existence of two Panx1 proteins in zebrafish displaying distinct tissue distribution, protein modification and electrophysiological properties, suggests that both proteins fulfill different functions in vivo.

  3. The function of panx1 channel is significantly reduced following mutation of a single cysteine residue (C282W) in the fourth transmembrane region of panx1.

Human Pannexin 1 (PANX1) interaction partners

  1. CBX (show CBX1 Proteins) and other inhibitors, including probenecid, attenuate Panx1 channel activity through modulation of the first extracellular loop.

  2. Decreased Panx1 function is a response to cell acidification mediated by IFN-gamma-induced (show SAMHD1 Proteins) up-regulation of Duox2 (show DUOX2 Proteins).

  3. PANX-1 plays an important role in the release of cytokines and glutamate (show GRIN1 Proteins) in a tumor cell line.

  4. The frequency of Panx1-400C homozygotes was higher among cardiovascular patients with hyper-reactive platelets. The Panx1-400C variant encodes a gain-of-function channel that enhances collagen-induced ATP release and platelet aggregation.

  5. Pannexin1-dependent pathophysiological eATP release in lipoapoptosis is capable of stimulating migration of human monocytes

  6. Panx1 channels promote leukocyte adhesion and emigration through the venous wall during acute systemic inflammation.

  7. This review focuses on the known roles of Panx1 related to purinergic signalling in the vasculature focusing on post-translational modifications and channel gating mechanisms that may participate in the regulated release of ATP.

  8. Within this review, the regulation of Panx1 channels is discussed, with a focus on how they may contribute to platelet function.

  9. These findings indicate that Panx1 participates in urothelial mechanotransduction and signaling by providing a direct pathway for mechanically-induced ATP release and by functionally interacting with P2X7Rs

  10. Data show that mutation encoding a truncated form of the pannexin-1 (PANX1) channel, PANX1(1-89), as recurrently enriched in highly metastatic breast cancer cells.

Mouse (Murine) Pannexin 1 (PANX1) interaction partners

  1. ATP released by myocardial cells through Pannexin-1 channel during ischemia could evoke calcium responses in cardiac sympathetic nerve fibers.

  2. Platelets of Panx1-/- mice showed reduced collagen-induced aggregation as compared to those of WT mice.

  3. The observations of this study reveal a new role for Panx1 in NPC (show NPC1 Proteins) maintenance in the VZ and suggesting that targeting peri (show POSTN Proteins)-infarct Panx1 (in combination with other interventions) could improve outcomes after stroke.

  4. The role of Pannexin 1 is analyzed at the systems level, it is not required for normal taste perception. Further studies are needed to determine the role of this hemichannel in taste cells.

  5. Panx1 channels promote leukocyte adhesion and emigration through the venous wall during acute systemic inflammation.

  6. The PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.

  7. Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing

  8. But not in Casp11 (show CASP4 Proteins)(-/-), Panx1(-/-), or P2x7 (show P2RX7 Proteins)(-/-) mice.

  9. Px1 channels releasing ATP have any role in the constrictor actions of alpha1-adrenoceptor activation

  10. A molecular signature in the pannexin1 intracellular loop confers channel activation by the alpha1 adrenoreceptor in smooth muscle cells.

Pannexin 1 (PANX1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.

Gene names and symbols associated with Pannexin 1 Proteins (PANX1)

  • pannexin 1a (panx1a)
  • pannexin 1 (PANX1)
  • pannexin 1 (panx1)
  • pannexin 1 (Panx1)
  • Pannexin 1 (Panx1)
  • AI847747 protein
  • MRS1 protein
  • Pannexin-1 protein
  • pannexin1 protein
  • PANX1 protein
  • PX1 protein
  • UNQ2529 protein
  • zgc:55631 protein

Protein level used designations for Pannexin 1 Proteins (PANX1)

pannexin 1 , pannexin-1 , innexin

GENE ID SPECIES
393890 Danio rerio
466751 Pan troglodytes
697204 Macaca mulatta
772164 Gallus gallus
100014304 Monodelphis domestica
100170473 Xenopus (Silurana) tropicalis
100171730 Pongo abelii
24145 Homo sapiens
607532 Canis lupus familiaris
528169 Bos taurus
55991 Mus musculus
315435 Rattus norvegicus
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