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Structural component of the gap junctions and the hemichannels.. Additionally we are shipping Pannexin 3 Antibodies (24) and many more products for this protein.
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Case Report: osteosarcomatous transformation of axillary sweat gland neoplasm with high PANX3 expression.
Panx3 hemichannel is expressed in human odontoblast-like cells and mediates ATP release into the extracellular space.
Panx1 (show PANX1 Proteins) and Panx3 are co-expressed in human skeletal muscle myoblasts and play a pivotal role in dictating the proliferation and differentiation.
Data suggest that both up-regulation and down-regulation of expression of pannexins (PANX1 (show PANX1 Proteins), PANX2 (show PANX2 Proteins), PANX3) are associated with disease onset and/or progression; examples include neoplasms, multiple sclerosis, migraine, and hypertension. [REVIEW]
The 70 kDa immunoreactive species of Panx3 highly regulated during keratinocyte differentiation was shown to most likely correspond to another Panx3 isoform.
Panx3 functions to switch the chondrocyte cell fate from proliferation to differentiation by regulating the intracellular ATP/cAMP levels
although Panx1 (show PANX1 Proteins) and Panx3 share a common endoplasmic reticulum to Golgi secretory pathway to Cx43 (show GJA1 Proteins), their ultimate cell surface residency appears to be independent of cell contacts and the need for intact microtubules
These studies show that Panx1 (show PANX1 Proteins) and Panx3 have many characteristics that are distinct from Cx43 (show GJA1 Proteins) and that these proteins probably play an important biological role as single membrane channels.
Our results clearly show that Panx3 ablation produces phenotypic effects in mouse femora and humeri, and support the premise that Panx3 has a role in regulating long bone growth and development.
Panx3 functions as an endoplasmic reticulum (ER) Ca(2 (show CA2 Proteins)+) channel to promote differentiation, and it could rescue mineralization defects in Cx43 (show GJA1 Proteins)(-/-) calvarial cells.
Mice lacking Panx3 are resistant to the development of osteoarthritis.
results provide evidence of the crucial roles of Panx3 in vertebrate skeletal development in vivo.
Panx3 is a new regulator that promotes the switch from proliferation to differentiation of osteoprogenitors via multiple Panx3 signaling pathways.
Panx3 may serve an important role in bone development, and is a novel target for Runx2 (show RUNX2 Proteins)-dependent signaling.
Panx3 promotes osteoblast differentiation by functioning as an ER Ca(2 (show CA2 Proteins)+) channel and a hemichannel, and by forming gap junctions.
Panx1 (show PANX1 Proteins) and Panx3 are coexpressed in the mammalian epidermis, and the regulation of Panx1 (show PANX1 Proteins) plays a key role in keratinocyte differentiation.
Structural component of the gap junctions and the hemichannels.
, pannexin 3
, gap junction protein pannexin 3