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anti-Pantothenate Kinase 2 (PANK2) Antibodies

PANK2 encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Additionally we are shipping Pantothenate Kinase 2 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PANK2 80025 Q9BZ23
PANK2 74450  
PANK2 296167  
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Top anti-Pantothenate Kinase 2 Antibodies at antibodies-online.com

Showing 10 out of 79 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-PANK2 Pab in mouse liver tissue lysate (35ug/lane). PANK2(arrow) was detected using the purified Pab (1:60 dilution). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-PANK2 Pab in mouse liver tissue lysate (35ug/lane). PANK2(arrow) was detected using the purified Pab (1:40 dilution). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-PANK2 mouse monoclonal antibody. (ABIN2453420, Dilution 1:50) Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-PANK2 mouse monoclonal antibody. (ABIN2453420, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-PANK2 Pab (ABIN391237) in mouse liver tissue lysate (35 µg/lane). PANK2(arrow) was detected using the purified polyclonal antibody (1:60 dilution). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-PANK2 Pab (ABIN391238) in mouse liver tissue lysate (35 µg/lane). PANK2(arrow) was detected using the purified polyclonal antibody (1:40 dilution). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of PANK2 expression in HepG2 (A), MCF7 (B), HT29 (C), mouse liver (D), PC12 (E) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Mouse Un-conjugated IF, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IF, IHC, WB Anti-PANK2 mouse monoclonal antibody (ABIN2453419) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PANK2 (RC215676). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PANK2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PANK2. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PANK2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PANK2. Flow cytometric Analysis of Jurkat cells, using anti-PANK2 antibody (ABIN2453418), (Red), compared to a nonspecific negative control antibody (ABIN2453418), (Blue). 100 μL Log in to see 2 to 3 Days
$423.50
Details

PANK2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Pantothenate Kinase 2 Antibodies

  1. Human Polyclonal PANK2 Primary Antibody for EIA, WB - ABIN359320 : Ching, Westaway, Gitschier, Higgins, Hayflick: HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration. in Neurology 2002 (PubMed)
    Show all 5 references for ABIN359320

  2. Human Polyclonal PANK2 Primary Antibody for EIA, WB - ABIN359321 : Hörtnagel, Prokisch, Meitinger: An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria. in Human molecular genetics 2003 (PubMed)
    Show all 5 references for ABIN359321

  3. Human Monoclonal PANK2 Primary Antibody for FACS, IF - ABIN2453420 : Brunetti, Dusi, Morbin, Uggetti, Moda, DAmato, Giordano, dAmati, Cozzi, Levi, Hayflick, Tiranti: Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model. in Human molecular genetics 2012 (PubMed)
    Show all 2 references for ABIN2453420

More Antibodies against Pantothenate Kinase 2 Interaction Partners

Human Pantothenate Kinase 2 (PANK2) interaction partners

  1. Tissue or cellular hypoxic/ischemic injury within the globus pallidus may underlie the pathogenesis of pantothenate kinase (show FBL Antibodies)-associated neurodegeneration due to PANK2 mutations and apoE (show APOE Antibodies) aggregates.

  2. Mutations in PANK2 and CoASY lead, respectively, to PKAN and CoPAN forms of Neurodegeneration with brain iron accumulation . Mutations in PLA2G6 lead to PLAN. Mutations in C19orf12 lead to MPAN

  3. Data suggests that the c.680 A>G mutation in the PANK2 gene alone is not sufficient to determine acanthocytic shape transformation in erythrocytes but some additional factor(s)/condition(s) are necessary for acanthocytosis to occur.

  4. Novel PANK2 gene mutations and clinical features in patients with pantothenate kinase (show FBL Antibodies)-associated neurodegeneration.

  5. study presents 2 siblings who were homozygous for a novel c.695A>G (p.Asp232Gly) missense mutation in exon 2 of PANK2 gene; index patient presented with a 5-year history of slowly progressive gait disturbance, dysarthria, mild axial rigidity and bradykinesia

  6. Caucasian patients have more complex presentations than Asians. Exon 3 and 4 are hot spots for screening PANK2 mutations in Asian patients.

  7. we describe the clinical, radiological, and molecular find-ings of a classic PKAN patient of Iranian descent with a novel frameshift mutation in the coding region of the PANK2 gene

  8. Identification of novel compound heterozygous mutations in PANK2 gene in two Chinese siblings with atypical pantothenate kinase (show FBL Antibodies)-associated neurodegeneration.

  9. Mutations in both PANK2 and C19orf12 contributed significantly to neurodegeneration with brain iron accumulation in the Iranian patients

  10. Skin fibroblasts from pantothenate kinase (show FBL Antibodies)-associated neurodegeneration patients highlight a possible molecular relationship between Pank2 deficiency and iron misregulation.

Mouse (Murine) Pantothenate Kinase 2 (PANK2) interaction partners

  1. Pank2(-/-) mice fed with a ketogenic diet developed a pantothenate kinase (show FBL Antibodies)-associated neurodegeneration-like syndrome

  2. Data demonstrate that Pank2 localizes to mitochondria. Pank2-defective neurons have an altered mitochondrial membrane potential, a defect further corroborated by swollen mitochondria at the ultra-structural level and by defective respiration.

  3. The data indicate that PanK1 and PanK2 can compensate for each other to supply tissue CoA.

  4. expression of PanK2 was higher in human brain compared to mouse brain

Pantothenate Kinase 2 (PANK2) Antigen Profile

Protein Summary

This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.

Gene names and symbols associated with PANK2

  • pantothenate kinase 2 (PANK2) antibody
  • pantothenate kinase 2 (Tsp_01576) antibody
  • pantothenate kinase 2 (Pank2) antibody
  • ribonuclease, RNase A family, 11 (non-active) (RNASE11) antibody
  • 4933409I19Rik antibody
  • AI642621 antibody
  • ATPANK2 antibody
  • C20orf48 antibody
  • F10M6.180 antibody
  • F10M6_180 antibody
  • HARP antibody
  • HSS antibody
  • NBIA1 antibody
  • PANK2 antibody
  • pantothenate kinase 2 antibody
  • PKAN antibody

Protein level used designations for PANK2

pantothenate kinase 2 (Hallervorden-Spatz syndrome) , pantothenate kinase 2 , pantothenate kinase 2, mitochondrial-like , Hallervorden-Spatz syndrome , pantothenate kinase 2, mitochondrial , pantothenic acid kinase 2

GENE ID SPECIES
458070 Pan troglodytes
829351 Arabidopsis thaliana
10911642 Trichinella spiralis
100217410 Ovis aries
100432599 Pongo abelii
100539295 Meleagris gallopavo
80025 Homo sapiens
74450 Mus musculus
477168 Canis lupus familiaris
296167 Rattus norvegicus
783426 Bos taurus
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