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Pantothenate Kinase 2 (PANK2) ELISA Kits

PANK2 encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Additionally we are shipping Pantothenate Kinase 2 Antibodies (81) and Pantothenate Kinase 2 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human PANK2 PANK2 80025 Q9BZ23
Anti-Mouse PANK2 PANK2 74450  
Anti-Rat PANK2 PANK2 296167  
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More ELISA Kits for Pantothenate Kinase 2 Interaction Partners

Human Pantothenate Kinase 2 (PANK2) interaction partners

  1. Tissue or cellular hypoxic/ischemic injury within the globus pallidus may underlie the pathogenesis of pantothenate kinase (show FBL ELISA Kits)-associated neurodegeneration due to PANK2 mutations and apoE (show APOE ELISA Kits) aggregates.

  2. Mutations in PANK2 and CoASY lead, respectively, to PKAN and CoPAN forms of Neurodegeneration with brain iron accumulation . Mutations in PLA2G6 lead to PLAN. Mutations in C19orf12 lead to MPAN

  3. Data suggests that the c.680 A>G mutation in the PANK2 gene alone is not sufficient to determine acanthocytic shape transformation in erythrocytes but some additional factor(s)/condition(s) are necessary for acanthocytosis to occur.

  4. Novel PANK2 gene mutations and clinical features in patients with pantothenate kinase (show FBL ELISA Kits)-associated neurodegeneration.

  5. study presents 2 siblings who were homozygous for a novel c.695A>G (p.Asp232Gly) missense mutation in exon 2 of PANK2 gene; index patient presented with a 5-year history of slowly progressive gait disturbance, dysarthria, mild axial rigidity and bradykinesia

  6. Caucasian patients have more complex presentations than Asians. Exon 3 and 4 are hot spots for screening PANK2 mutations in Asian patients.

  7. we describe the clinical, radiological, and molecular find-ings of a classic PKAN patient of Iranian descent with a novel frameshift mutation in the coding region of the PANK2 gene

  8. Identification of novel compound heterozygous mutations in PANK2 gene in two Chinese siblings with atypical pantothenate kinase (show FBL ELISA Kits)-associated neurodegeneration.

  9. Mutations in both PANK2 and C19orf12 contributed significantly to neurodegeneration with brain iron accumulation in the Iranian patients

  10. Skin fibroblasts from pantothenate kinase (show FBL ELISA Kits)-associated neurodegeneration patients highlight a possible molecular relationship between Pank2 deficiency and iron misregulation.

Mouse (Murine) Pantothenate Kinase 2 (PANK2) interaction partners

  1. Pank2(-/-) mice fed with a ketogenic diet developed a pantothenate kinase (show FBL ELISA Kits)-associated neurodegeneration-like syndrome

  2. Data demonstrate that Pank2 localizes to mitochondria. Pank2-defective neurons have an altered mitochondrial membrane potential, a defect further corroborated by swollen mitochondria at the ultra-structural level and by defective respiration.

  3. The data indicate that PanK1 and PanK2 can compensate for each other to supply tissue CoA.

  4. expression of PanK2 was higher in human brain compared to mouse brain

Pantothenate Kinase 2 (PANK2) Antigen Profile

Antigen Summary

This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.

Gene names and symbols associated with PANK2

  • pantothenate kinase 2 (PANK2) antibody
  • pantothenate kinase 2 (Tsp_01576) antibody
  • pantothenate kinase 2 (Pank2) antibody
  • ribonuclease, RNase A family, 11 (non-active) (RNASE11) antibody
  • 4933409I19Rik antibody
  • AI642621 antibody
  • ATPANK2 antibody
  • C20orf48 antibody
  • F10M6.180 antibody
  • F10M6_180 antibody
  • HARP antibody
  • HSS antibody
  • NBIA1 antibody
  • PANK2 antibody
  • pantothenate kinase 2 antibody
  • PKAN antibody

Protein level used designations for PANK2

pantothenate kinase 2 (Hallervorden-Spatz syndrome) , pantothenate kinase 2 , pantothenate kinase 2, mitochondrial-like , Hallervorden-Spatz syndrome , pantothenate kinase 2, mitochondrial , pantothenic acid kinase 2

GENE ID SPECIES
458070 Pan troglodytes
829351 Arabidopsis thaliana
10911642 Trichinella spiralis
100217410 Ovis aries
100432599 Pongo abelii
100539295 Meleagris gallopavo
80025 Homo sapiens
74450 Mus musculus
477168 Canis lupus familiaris
296167 Rattus norvegicus
783426 Bos taurus
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