Pappalysin 2 Proteins (PAPPA2)

Metalloproteinase which specifically cleaves IGFBP-5. Additionally we are shipping Pappalysin 2 Antibodies (46) and Pappalysin 2 Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse PAPPA2 PAPPA2 23850  
PAPPA2 60676 Q9BXP8
Rat PAPPA2 PAPPA2 364027  
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Top Pappalysin 2 Proteins at

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 20 to 21 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days

PAPPA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Top referenced Pappalysin 2 Proteins

  1. Human PAPPA2 Protein expressed in Human Cells - ABIN2003006 : Crosley, Durland, Seethram, MacRae, Gruslin, Christians: First-trimester levels of pregnancy-associated plasma protein A2 (PAPP-A2) in the maternal circulation are elevated in pregnancies that subsequently develop preeclampsia. in Reproductive sciences (Thousand Oaks, Calif.) 2014 (PubMed)

More Proteins for Pappalysin 2 (PAPPA2) Interaction Partners

Zebrafish Pappalysin 2 (PAPPA2) interaction partners

  1. Papp-a2 modulates Bmp and Notch (show NOTCH1 Proteins) signaling by independent mechanisms in zebrafish embryos to control cranial cartilage development and angiogenesis.

Mouse (Murine) Pappalysin 2 (PAPPA2) interaction partners

  1. Locally-produced Pappa2 in osteoblasts, epiphysis, and metaphysis, is required for normal postnatal bone growth.

  2. Despite a dramatic disruption of the balance between circulating IGF-I (show IGF1 Proteins), IGFBP-3 (show IGFBP3 Proteins) and -5, we found no effects of Pappa2 deletion on glucose metabolism, weight gain or adiposity on a high-fat diet.

  3. Pappa2 deletion had no effect on female reproduction and subtle effects on male fertility.

  4. Pappa2 is responsible for the effects of the previously-identified QTL, demonstrating that natural variation in the Pappa2 gene contributes to variation in postnatal growth in mice

  5. investigation of biological role of PAPP-A2 using knockout mice, heterozygotes, primary fibroblasts: The most striking phenotype of PAPP-A2 KO mice was postnatal growth retardation. PAPP-A2 KO mice were fertile, but exhibited compromised fecundity.

  6. Elevated PAPPA2 levels are a consequence rather than a cause of pregnancy complications.

  7. The refinement of the target region to four genes and the finding that the QTL affects IGFBP-5 (show IGFBP5 Proteins) levels suggest that PAPPA2 may be involved with normal postnatal growth

  8. Pappa2 expression also shows specific localization within the mouse embryo and therefore may play roles in fetal development, independent of its action in the placenta

Human Pappalysin 2 (PAPPA2) interaction partners

  1. These patients provide important insights into the regulation of longitudinal growth in humans, documenting the critical role of PAPP-A2 in releasing IGF-I (show IGF1 Proteins) from its binding proteins.

  2. Short-term treatment with progressive doses of rhIGF1 (recombinant human insulin-like growth factor-1 (show IGF1 Proteins)) improved growth in two siblings with deficiency of PAPP-A2 (pregnancy-associated plasma protein-A2) [due to a homozygous loss-of-function frameshift mutation in exon 3 of the PAPP-A2 gene (p.D643fs25*)] that resulted in postnatal growth failure due to resulting decrease in IGF1 (show IGF1 Proteins) bioavailability. [CASE REPORT]

  3. in situ hybridization (ISH (show ANTXR2 Proteins)) and immunohistochemistry (IHC) were employed to examine the spatial and temporal expression of PAPPA2 in the human fetomaternal interface.

  4. PAPP-A2 is differentially expressed in different trophoblast populations and shows strong down regulation in the mid second trimester in chorionic villous samples.

  5. The association between this PAPPA2 single nucleotide polymorphism and developmental dysplasia of the hip was evaluated.

  6. The upregulation of PAPP-A2 observed in preeclampsia at term occurs early in pregnancy, before the symptoms develop.

  7. PAPPA2 may be upregulated in severe pre-eclampsia and, functionally, this may be mediated via increased placental hypoxia known to occur with this pregnancy disorder.

  8. The existence of this assay will enable an assessment of the biomarker potential of PAPP-A2 in pre-eclampsia as well as other clinical conditions.

  9. Association of a single nucleotide polymorphism in pregnancy-associated plasma protein-A2 with developmental dysplasia of the hip

  10. factors previously known to be highly expressed in preeclamptic placentae (PGE2 and TNF-alpha (show TNF Proteins)), contribute to the upregulation of PAPPA2. results are consistent with the hypothesis that PAPPA2 is upregulated as a consequence of placental pathology

Cow (Bovine) Pappalysin 2 (PAPPA2) interaction partners

  1. Variants in the pregnancy-associated plasma protein-A2 gene on Bos taurus autosome 16 are associated with daughter calving ease and productive life in Holstein cattle.

Pappalysin 2 (PAPPA2) Protein Profile

Protein Summary

Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.

Gene names and symbols associated with Pappalysin 2 Proteins (PAPPA2)

  • pappalysin 2 (PAPPA2)
  • pappalysin 2 (pappa2)
  • pappalysin 2 (Pappa2)
  • pappalysin 2 (LOC100357077)
  • PAPP-A2 protein
  • PAPP-E protein
  • PAPPE protein
  • PLAC3 protein
  • si:dkey-39f8.1 protein

Protein level used designations for Pappalysin 2 Proteins (PAPPA2)

pappalysin 2 , pappalysin-2-like , placenta-specific 3 , pregnancy-associated plasma preproprotein-A2 , pregnancy-associated plasma protein-E , pappalysin-2 , pregnancy-associated plasma protein E1

457543 Pan troglodytes
567038 Danio rerio
100021506 Monodelphis domestica
100052718 Equus caballus
100447000 Pongo abelii
100468592 Ailuropoda melanoleuca
100491868 Xenopus (Silurana) tropicalis
100567326 Anolis carolinensis
100582901 Nomascus leucogenys
23850 Mus musculus
60676 Homo sapiens
364027 Rattus norvegicus
100357077 Oryctolagus cuniculus
100736235 Cavia porcellus
100521390 Sus scrofa
480058 Canis lupus familiaris
538320 Bos taurus
429071 Gallus gallus
101118205 Ovis aries
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