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Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) (PARD6A) ELISA Kits

PARD6A is a member of the PAR6 family and encodes a protein with a PSD95\\/Discs-large\\/ZO1 (PDZ) domain and a semi-Cdc42\\/Rac interactive binding (CRIB) domain. Additionally we are shipping Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) Antibodies (69) and Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse PARD6A PARD6A 56513 Q9Z101
Anti-Rat PARD6A PARD6A 307799 Q6B4M5
Anti-Human PARD6A PARD6A 50855 Q9NPB6
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More ELISA Kits for Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) Interaction Partners

Mouse (Murine) Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) (PARD6A) interaction partners

  1. Lgl1 forms two distinct complexes in vivo, Lgl1-NMIIA and Lgl1-Par6alpha-aPKCzeta (show PRKCZ ELISA Kits), and that the formation of these complexes is affected by the phosphorylation state of Lgl1.

  2. Our results provide the first in vivo characterization of RalA (show rala ELISA Kits) function in the mammalian brain and highlight a novel

  3. The nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei which is driven by microtubules and dynein/dynactin (show DCTN1 ELISA Kits) complex, and requires Cdc42 (show CDC42 ELISA Kits), Par6 and Par3 (show F2RL2 ELISA Kits).

  4. PAR6 has a role in forming primordial follicles in mouse ovary

  5. Rin (show RIT2 ELISA Kits) and Rit (show RIT1 ELISA Kits) Bind to PAR6 GTP (show AK3 ELISA Kits)-dependently and regulate cell transformation

  6. Par6alpha-mediated inhibition of insulin (show INS ELISA Kits)-dependent glycogen (show GYS1 ELISA Kits) synthesis in C2C12 cells depends on the direct interaction of Par6alpha with aPKC and on aPKC-mediated T34 phosphorylation of Akt1 (show AKT1 ELISA Kits).

  7. In addition to regulating Par-6-aPKC localization, Cdc42 (show CDC42 ELISA Kits) increases aPKC activity by relieving Par-6 inhibition.

  8. Neph1 (show NEPH1 ELISA Kits)-Nephrin (show NPHS1 ELISA Kits) proteins bind the Par3 (show F2RL2 ELISA Kits)-Par6-atypical protein kinase C (show PRKCZ ELISA Kits) (aPKC) complex to regulate podocyte cell polarity

  9. The aPKC-PAR3 complex associates with the nephrin-podocin complex in podocytes through direct interaction between PAR3 and nephrin, and the kinase activity of aPKC is required for the appropriate distribution of nephrin and podocin in podocytes.

  10. the TGFbeta (show TGFB1 ELISA Kits)-Par6 polarity pathway has a role in breast cancer progression

Human Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) (PARD6A) interaction partners

  1. Shp2 (show PTPN11 ELISA Kits) promotes metastasis of prostate cancer by attenuating the PAR3 (show F2RL2 ELISA Kits)/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition

  2. TGFbeta (show TGFB1 ELISA Kits) induced Par6 phosphorylation on Ser345 and its recruitment to the leading edge of the membrane ruffle in migrating PC-3U cells, where it colocalised with aPKCzeta (show PRKCZ ELISA Kits). The p-Par6-aPKCzeta (show PRKCZ ELISA Kits) complex is important for cell migration and invasion.

  3. Data indicate that both tumor focality and Par3 (show F2RL2 ELISA Kits)/Par6/atypical protein kinase C (show PRKCZ ELISA Kits) (APKC) expression were significantly associated with tumor recurrence.

  4. BDNF (show BDNF ELISA Kits) can regulate formation of functional synapses by increasing the expression of the RhoA (show RHOA ELISA Kits) inhibitors, Par6C and Rnd3 (show RND3 ELISA Kits).

  5. Morg1 (show wdr83 ELISA Kits) facilitates Par6-aPKC binding to Crb3 (show CRB3 ELISA Kits) for definition of apical identity of epithelial cells.

  6. Par6 negatively regulates trophoblast fusion via its roles on tight junctions and cytoskeleton dynamics and provide novel insight into the contribution of this polarity marker in altered trophoblast cell fusion typical of preeclampsia.

  7. Atypical protein kinase C (show PRKCZ ELISA Kits) kinase activity, as well as an association with PAR6, were found to be important for PAR6 phosphorylation.

  8. Pak6 (show PAK6 ELISA Kits) is a binding partner and a outatuve effector protein for the atypical rho GTPase (show RACGAP1 ELISA Kits) cdc42 (show CDC42 ELISA Kits) homologous protein.

  9. Data show that DDR1 coordinates the Par3 (show F2RL2 ELISA Kits)/Par6 cell-polarity complex through its carboxy terminus, binding PDZ (show INADL ELISA Kits) domains in Par3 (show F2RL2 ELISA Kits) and Par6.

  10. Par6alpha controls centrosome organization through its association with the dynactin (show DCTN1 ELISA Kits) subunit p150(Glued (show DCTN1 ELISA Kits)).

Caenorhabditis elegans (C. elegans) Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) (PARD6A) interaction partners

  1. Our results support a model in which CYB (show CSTB ELISA Kits)-2.1/2/CDK-1 (show CDK1 ELISA Kits) antagonize CUL-2 (show CUL2 ELISA Kits) activity to promote stabilization of PAR-6 levels during polarization of the early C. elegans embryo.

  2. the arcade cell epithelium polarizes by a PAR-6-mediated pathway that is independent of E-cadherin (show CDH1 ELISA Kits), beta-integrin and beta-laminin.

  3. PAR-3 and PAR-6 function in cytokinesis may be partially redundant and play a role in the maintenance of DYN-1 in the cleavage furrow.

  4. evidence PAR (show AFG3L2 ELISA Kits) polarity arises from coupling of advective transport by flowing cell cortex to a multistable PAR (show AFG3L2 ELISA Kits) reaction-diffusion system; advection in active, flowing medium provides mechanism for mechanically templated pattern formation in development

  5. Centrosomes localize apically by first moving toward lateral foci of the conserved polarity proteins PAR-3 and PAR-6, then move together with these foci toward the future apical surface. Embryos lacking PAR-3 fail to localize their centrosomes apically.

  6. PAR-2 (show F2RL1 ELISA Kits) and PAR-6, which localize to opposing PAR (show AFG3L2 ELISA Kits) domains, undergo exchange between well mixed cytoplasmic populations and laterally diffusing membrane-associated states

  7. Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain (show INADL ELISA Kits) ligand, is required for PAR-6 function in C. elegans

  8. PAR (show AFG3L2 ELISA Kits) proteins function in both apicobasal and anterior-posterior asymmetry during the first few cell cycles of embryogenesis.

  9. CDC-37-mediated inhibition of the CDC-42 (show CDC42 ELISA Kits)-dependent binding site and PAR-3-mediated release of this inhibition provide a key mechanism for the anterior accumulation of PAR-6.

  10. CDC-42 (show CDC42 ELISA Kits) interaction with PAR-6 is not required for the initial establishment of asymmetry but is required for maximal cortical accumulation of PAR-6 and to maintain its asymmetry.

Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) (PARD6A) Antigen Profile

Antigen Summary

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with PARD6A

  • par-6 partitioning defective 6 homolog alpha (C. elegans) (PARD6A) antibody
  • par-6 (partitioning defective 6,) homolog alpha (C. elegans) (Pard6a) antibody
  • par-6 family cell polarity regulator alpha (PARD6A) antibody
  • Protein PAR-6 (par-6) antibody
  • 0710008C04Rik antibody
  • 2610010A15Rik antibody
  • Par-6 antibody
  • PAR-6A antibody
  • PAR6 antibody
  • Par6a antibody
  • PAR6alpha antibody
  • PAR6C antibody
  • PARD6A antibody
  • TAX40 antibody
  • TIP-40 antibody

Protein level used designations for PARD6A

par-6 partitioning defective 6 homolog alpha (C. elegans) , partitioning defective 6 homolog alpha , PAR-6 alpha , PAR-6A , Tax interaction protein 40 , partitioning defective protein 6A , Tax-interacting protein 40 , par-6 partitioning defective 6 homolog alpha , partitioning defective-6 homolog alpha , partitioning-defective protein 6 , tax interaction protein 40

427529 Gallus gallus
489756 Canis lupus familiaris
699351 Macaca mulatta
100586482 Nomascus leucogenys
56513 Mus musculus
307799 Rattus norvegicus
50855 Homo sapiens
173137 Caenorhabditis elegans
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