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Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) Proteins (PARD6A)

PARD6A is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. Additionally we are shipping Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) Antibodies (66) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PARD6A 56513 Q9Z101
Rat PARD6A PARD6A 307799 Q6B4M5
PARD6A 50855 Q9NPB6
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Top Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Caenorhabditis elegans His tag   1 mg Log in to see 56 to 66 Days
$2,825.17
Details

PARD6A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) (PARD6A) Interaction Partners

Mouse (Murine) Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) (PARD6A) interaction partners

  1. Lgl1 (show Klra7 Proteins) forms two distinct complexes in vivo, Lgl1 (show Klra7 Proteins)-NMIIA and Lgl1 (show Klra7 Proteins)-Par6alpha-aPKCzeta (show PRKCZ Proteins), and that the formation of these complexes is affected by the phosphorylation state of Lgl1 (show Klra7 Proteins).

  2. Our results provide the first in vivo characterization of RalA (show rala Proteins) function in the mammalian brain and highlight a novel

  3. The nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei which is driven by microtubules and dynein/dynactin (show DCTN1 Proteins) complex, and requires Cdc42 (show CDC42 Proteins), Par6 and Par3 (show F2RL2 Proteins).

  4. PAR6 has a role in forming primordial follicles in mouse ovary

  5. Rin (show RIT2 Proteins) and Rit (show RIT1 Proteins) Bind to PAR6 GTP (show AK3 Proteins)-dependently and regulate cell transformation

  6. Par6alpha-mediated inhibition of insulin (show INS Proteins)-dependent glycogen (show GYS1 Proteins) synthesis in C2C12 cells depends on the direct interaction of Par6alpha with aPKC and on aPKC-mediated T34 phosphorylation of Akt1 (show AKT1 Proteins).

  7. In addition to regulating Par-6-aPKC localization, Cdc42 (show CDC42 Proteins) increases aPKC activity by relieving Par-6 inhibition.

  8. Neph1 (show NEPH1 Proteins)-Nephrin (show NPHS1 Proteins) proteins bind the Par3 (show F2RL2 Proteins)-Par6-atypical protein kinase C (show PRKCZ Proteins) (aPKC) complex to regulate podocyte cell polarity

  9. The aPKC-PAR3 complex associates with the nephrin-podocin complex in podocytes through direct interaction between PAR3 and nephrin, and the kinase activity of aPKC is required for the appropriate distribution of nephrin and podocin in podocytes.

  10. the TGFbeta (show TGFB1 Proteins)-Par6 polarity pathway has a role in breast cancer progression

Human Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) (PARD6A) interaction partners

  1. Shp2 (show PTPN11 Proteins) promotes metastasis of prostate cancer by attenuating the PAR3 (show F2RL2 Proteins)/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition

  2. TGFbeta (show TGFB1 Proteins) induced Par6 phosphorylation on Ser345 and its recruitment to the leading edge of the membrane ruffle in migrating PC-3U cells, where it colocalised with aPKCzeta (show PRKCZ Proteins). The p-Par6-aPKCzeta (show PRKCZ Proteins) complex is important for cell migration and invasion.

  3. Data indicate that both tumor focality and Par3 (show F2RL2 Proteins)/Par6/atypical protein kinase C (show PRKCZ Proteins) (APKC) expression were significantly associated with tumor recurrence.

  4. BDNF (show BDNF Proteins) can regulate formation of functional synapses by increasing the expression of the RhoA (show RHOA Proteins) inhibitors, Par6C and Rnd3 (show RND3 Proteins).

  5. Morg1 (show wdr83 Proteins) facilitates Par6-aPKC binding to Crb3 (show CRB3 Proteins) for definition of apical identity of epithelial cells.

  6. Par6 negatively regulates trophoblast fusion via its roles on tight junctions and cytoskeleton dynamics and provide novel insight into the contribution of this polarity marker in altered trophoblast cell fusion typical of preeclampsia.

  7. Atypical protein kinase C (show PRKCZ Proteins) kinase activity, as well as an association with PAR6, were found to be important for PAR6 phosphorylation.

  8. Pak6 (show PAK6 Proteins) is a binding partner and a outatuve effector protein for the atypical rho GTPase (show RACGAP1 Proteins) cdc42 (show CDC42 Proteins) homologous protein.

  9. Data show that DDR1 (show DDR1 Proteins) coordinates the Par3 (show F2RL2 Proteins)/Par6 cell-polarity complex through its carboxy terminus, binding PDZ domains in Par3 (show F2RL2 Proteins) and Par6.

  10. Par6alpha controls centrosome organization through its association with the dynactin (show DCTN1 Proteins) subunit p150(Glued (show DCTN1 Proteins)).

Caenorhabditis elegans (C. elegans) Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) (PARD6A) interaction partners

  1. Our results support a model in which CYB (show CSTB Proteins)-2.1/2/CDK-1 (show CDK1 Proteins) antagonize CUL-2 (show CUL2 Proteins) activity to promote stabilization of PAR-6 levels during polarization of the early C. elegans embryo.

  2. the arcade cell epithelium polarizes by a PAR-6-mediated pathway that is independent of E-cadherin (show CDH1 Proteins), beta-integrin and beta-laminin.

  3. PAR-3 and PAR-6 function in cytokinesis may be partially redundant and play a role in the maintenance of DYN-1 in the cleavage furrow.

  4. evidence PAR (show AFG3L2 Proteins) polarity arises from coupling of advective transport by flowing cell cortex to a multistable PAR (show AFG3L2 Proteins) reaction-diffusion system; advection in active, flowing medium provides mechanism for mechanically templated pattern formation in development

  5. Centrosomes localize apically by first moving toward lateral foci of the conserved polarity proteins PAR-3 and PAR-6, then move together with these foci toward the future apical surface. Embryos lacking PAR-3 fail to localize their centrosomes apically.

  6. PAR-2 (show F2RL1 Proteins) and PAR-6, which localize to opposing PAR (show AFG3L2 Proteins) domains, undergo exchange between well mixed cytoplasmic populations and laterally diffusing membrane-associated states

  7. Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegans

  8. PAR (show AFG3L2 Proteins) proteins function in both apicobasal and anterior-posterior asymmetry during the first few cell cycles of embryogenesis.

  9. CDC-37-mediated inhibition of the CDC-42 (show CDC42 Proteins)-dependent binding site and PAR-3-mediated release of this inhibition provide a key mechanism for the anterior accumulation of PAR-6.

  10. CDC-42 (show CDC42 Proteins) interaction with PAR-6 is not required for the initial establishment of asymmetry but is required for maximal cortical accumulation of PAR-6 and to maintain its asymmetry.

Par-6 Partitioning Defective 6 Homolog alpha (C. Elegans) (PARD6A) Protein Profile

Protein Summary

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with PARD6A

  • par-6 partitioning defective 6 homolog alpha (C. elegans) (PARD6A)
  • par-6 (partitioning defective 6,) homolog alpha (C. elegans) (Pard6a)
  • par-6 family cell polarity regulator alpha (PARD6A)
  • Protein PAR-6 (par-6)
  • 0710008C04Rik protein
  • 2610010A15Rik protein
  • Par-6 protein
  • PAR-6A protein
  • PAR6 protein
  • Par6a protein
  • PAR6alpha protein
  • PAR6C protein
  • PARD6A protein
  • TAX40 protein
  • TIP-40 protein

Protein level used designations for PARD6A

par-6 partitioning defective 6 homolog alpha (C. elegans) , partitioning defective 6 homolog alpha , PAR-6 alpha , PAR-6A , Tax interaction protein 40 , partitioning defective protein 6A , Tax-interacting protein 40 , par-6 partitioning defective 6 homolog alpha , partitioning defective-6 homolog alpha , partitioning-defective protein 6 , tax interaction protein 40

GENE ID SPECIES
427529 Gallus gallus
489756 Canis lupus familiaris
699351 Macaca mulatta
100586482 Nomascus leucogenys
56513 Mus musculus
307799 Rattus norvegicus
50855 Homo sapiens
173137 Caenorhabditis elegans
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