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Paraoxonase 1 Proteins (PON1)

The enzyme encoded by PON1 is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Additionally we are shipping Paraoxonase 1 Antibodies (150) and Paraoxonase 1 Kits (65) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PON1 5444 P27169
PON1 18979 P52430
PON1 84024 P55159
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Top Paraoxonase 1 Proteins at

Showing 10 out of 28 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human His tag 10 μg Log in to see 6 to 11 Days

PON1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Paraoxonase 1 (PON1) Interaction Partners

Human Paraoxonase 1 (PON1) interaction partners

  1. toxicogenetics/genetic association study in population in Turkey: Data suggest SNP in PON1 (192Q/R) is associated with susceptibility to organophosphate poisoning; plasma ACHE activities of exposed workers vary w/ PON1 genotype: 192RR>192QR>192QQ.

  2. PON-1 55 L/M and 192Q/R polymorphisms and allelic variants are not related with the risk for migraine in Turkish people.

  3. Data suggest that serum PON1 activity is up-regulated in subjects treated with cholesterol-lowering agents (fibrates with/without statins) in prevention of cardiovascular disease (CVD) in patients at risk for CVD. [META-ANALYSIS, REVIEW]

  4. Leu-9, Tyr (show TYR Proteins)-185, and Tyr (show TYR Proteins)-293 of PON1 are importance in binding to HDL (show HSD11B1 Proteins) and catalytic activity.

  5. PON1 Q192R polymorphism is likely to be a risk factor for cataract development in Pakistani population while PON1 L55M was not found to be associated with cataract.

  6. presence of an association between the PON1 gene polymorphism and serum levels of advanced glycation end products and advanced oxidation protein products in farmers occupationally exposed to pesticides

  7. Molecular dynamics simulation studies were employed on selected recombinant h-PON1 (rh-PON1) mutants to understand the effect of amino acid substitutions at position 192 on the structural features of the active site of the enzyme.

  8. PON1, P2Y12 (show P2RY12 Proteins) and COX1 polymorphisms were associated with poorer vascular outcomes in patients with extracranial or intracranial stents.

  9. To evaluate the association of the paraoxonase 1 (PON1) gene polymorphisms c.-108C>T, p.L55M, and p.Q192R with the risk of glioma in Southeast Mexico

  10. This study identified that PON1 L55M associated with Vascular Dementia.

Mouse (Murine) Paraoxonase 1 (PON1) interaction partners

  1. results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL (show HSD11B1 Proteins), owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis.

  2. Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes.

  3. 5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1.

  4. HDL (show HSD11B1 Proteins) (mostly HDL3), stimulates PON1 antiatherogenic activities in mouse macrophages.

  5. Findings suggest that Pon1 interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis

  6. The study demonstrated a significant decline in PON1 activity which correlates with increased LDL oxidation after 8 months of age in Wistar rats.

  7. PON1 plays a protective role against hepatic derangements, secondary to fat and cholesterol overnutrition. PON1 deficiency is associated with oxidative stress and metabolic alterations leading to liver steatosis.

  8. PON1 is not essential for normal development, function, ageing, and the defense against light damage of the mouse retina.

  9. Suggest that PON1 decreases sustained pro-inflammatory reactions, which subsequently can attenuate plaque progression.

  10. PON1 plays a beneficial role in glucose regulation and metabolism and may serve as an important tool in diabetes control.

Pig (Porcine) Paraoxonase 1 (PON1) interaction partners

  1. PON1 behaves as a negative acute phase protein (show ORM1 Proteins) in pigs since a significant decrease (P<0.05) in its activity after 72 h of the induction of the inflammation was observed with all substrates.

Cow (Bovine) Paraoxonase 1 (PON1) interaction partners

  1. The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.

  2. Data indicate that Cu(2+), Mn(2+), Zn(2+), Ni(2 (show VMP1 Proteins)+), and Pb(2+) were found to inhibite the paraoxonase 1 (PON1) enzyme activity in a concentration-dependent fashion.

  3. The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.

  4. Significantly lower PON1 activity and PON1/high density lipoprotein ratio in lactating cows compared to heifers showed that metabolic efforts during pregnancy, parturition and lactation influence PON1 activity due to oxidative stress.

  5. The activity of PON1 and malondialdehyde in late pregnancy and early lactation in dairy cattle is reported.

Rabbit Paraoxonase 1 (PON1) interaction partners

  1. ApoE (show APOE Proteins) mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Proteins) paraoxonase activity

  2. PON1 can decrease the AChE inhibition, and alleviated clinical signs and tissue damage caused by dichlorvos.

Paraoxonase 1 (PON1) Protein Profile

Protein Summary

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Gene names and symbols associated with Paraoxonase 1 Proteins (PON1)

  • paraoxonase 1 (pon1)
  • paraoxonase 1 (PON1)
  • paraoxonase 1 (Pon1)
  • ESA protein
  • MGC53915 protein
  • MGC89222 protein
  • MVCD5 protein
  • Pon protein
  • PON1 protein
  • pon2 protein

Protein level used designations for Paraoxonase 1 Proteins (PON1)

paraoxonase 1 , paraoxonase 2 , serum paraoxonase/arylesterase 1-like , A-esterase 1 , K-45 , PON 1 , aromatic esterase 1 , arylesterase B-type , esterase A , paraoxonase B-type , serum aryldiakylphosphatase , serum aryldialkylphosphatase 1 , serum paraoxonase/arylesterase 1 , serum paraoxonase

448598 Xenopus (Silurana) tropicalis
463547 Pan troglodytes
699355 Macaca mulatta
100408915 Callithrix jacchus
100436640 Pongo abelii
100602768 Nomascus leucogenys
5444 Homo sapiens
18979 Mus musculus
84024 Rattus norvegicus
475234 Canis lupus familiaris
100048952 Sus scrofa
523798 Bos taurus
100009133 Oryctolagus cuniculus
100721268 Cavia porcellus
101116983 Ovis aries
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