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The enzyme encoded by PON1 is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Additionally we are shipping Paraoxonase 1 Kits (69) and Paraoxonase 1 Proteins (25) and many more products for this protein.
Showing 10 out of 172 products:
Human Monoclonal PON1 Primary Antibody for ICC, FACS - ABIN1724910
Yesilova, Turan, Ucmak, Selek, Halil Yavuz, Tanr?kulu: Reduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress. in Redox report : communications in free radical research 2012
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Human Monoclonal PON1 Primary Antibody for FACS, IHC - ABIN1724909
Saadat: Paraoxonase 1 genetic polymorphisms and susceptibility to breast cancer: a meta-analysis. in Cancer epidemiology 2012
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Human Polyclonal PON1 Primary Antibody for IHC, IHC (p) - ABIN4346826
Lescuyer, Pernin, Hainard, Bigeire, Burgess, Zimmermann-Ivol, Sanchez, Schifferli, Hochstrasser, Moll: Proteomic analysis of a podocyte vesicle-enriched fraction from human normal and pathological urine samples. in Proteomics. Clinical applications 2010
Show all 2 Pubmed References
Human Polyclonal PON1 Primary Antibody for ELISA, WB - ABIN439721
Bhattacharyya, Nicholls, Topol, Zhang, Yang, Schmitt, Fu, Shao, Brennan, Ellis, Brennan, Allayee, Lusis, Hazen: Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. in JAMA 2008
Human Monoclonal PON1 Primary Antibody for ELISA, WB - ABIN519040
Cubedo, Padró, Alonso, Mata, Badimon: ApoL1 levels in high density lipoprotein and cardiovascular event presentation in patients with familial hypercholesterolemia. in Journal of lipid research 2016
Human Polyclonal PON1 Primary Antibody for ELISA, WB - ABIN562316
Gupta, Kandimalla, Priyanka, Singh, Gill, Singh: Effect of Resveratrol and Nicotine on PON1 Gene Expression: In Vitro Study. in Indian journal of clinical biochemistry : IJCB 2014
Human Polyclonal PON1 Primary Antibody for FACS, IHC (p) - ABIN654641
Guglielmetti, Mazza, Pagano, Carrella, Sciuto, Nodari, Pezzolato, Richelmi, Baioni, Caramelli, Acutis, Bozzetta: Identification by a proteomic approach of a plasma protein as a possible biomarker of illicit dexamethasone treatment in veal calves. in Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 2014
Cow (Bovine) Polyclonal PON1 Primary Antibody for IHC, WB - ABIN2776787
Penco, Buscema, Patrosso, Marocchi, Grossi: New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. in BMC bioinformatics 2008
rare genetic variation in PON1 was associated with ischemic stroke, with stronger associations identified in those of AA. Increased focus on PON1 enzyme function and its role in cerebrovascular disease is warranted.
PON1 arylesterase activity correlated negatively with sCD40L, ADMA, and sICAM-1 levels in overweight patients with newly diagnosed untreated hyperlipidaemia.
The results of various studies in different populations indicate that some SNPs of the PON1 gene are associated with stroke.
Genotype RR of PON1 Q192R is an independent risk factor predicting re-stenting in Chinese acute coronary syndrome patients after coronary stenting
Clinical observations focusing on gene polymorphisms of PON indicate that three different genotypes of polymorphism PON1Q192R have unequal degrees atheroprotective properties.
the measurement of serum PON1 concentration post-radiotherapy (RT) could be an efficient prognostic biomarker, and may be used as an index of the efficacy of the RT.
Patients with the Q allele of the PON1 Q192R polymorphism who were treated with statins exhibited improvement in glucose metabolism, especially in insulin (show INS Antibodies) secretion, suggesting the importance of genotyping PON1 Q192R to identify those who could benefit from statin therapy.
PON1 and CYP2C19 (show CYP2C19 Antibodies) polymorphisms were associated with lower clopidogrel responsiveness in this sample.
generated a meta-marker model made up of SERPINA4 (show SERPINA4 Antibodies) and PON1 that is useful as a differential diagnostic biomarker differentiating lung cancer from other lung diseases.
Our study showed that although lipoic acid up-regulates PON3 (show PON3 Antibodies) but down-regulates PON1 mRNA expression, it increases both PON1 and PON3 (show PON3 Antibodies) protein levels and arylesterase activity in HepG2 cells. We can report that lipoic acid may be useful for preventing atherosclerosis at therapeutic doses.
PON1 overexpression protects against AAA (show AAAS Antibodies) progression by reducing oxidative stress, apoptosis and inflammation
Paraoxonase 1 (PON1) influence circadian gene expression and period length
results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL (show HSD11B1 Antibodies), owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis.
Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes.
5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1.
HDL (show HSD11B1 Antibodies) (mostly HDL3), stimulates PON1 antiatherogenic activities in mouse macrophages.
Findings suggest that Pon1 interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis
The study demonstrated a significant decline in PON1 activity which correlates with increased LDL oxidation after 8 months of age in Wistar rats.
PON1 plays a protective role against hepatic derangements, secondary to fat and cholesterol overnutrition. PON1 deficiency is associated with oxidative stress and metabolic alterations leading to liver steatosis.
PON1 is not essential for normal development, function, ageing, and the defense against light damage of the mouse retina.
PON1 behaves as a negative acute phase protein (show ORM1 Antibodies) in pigs since a significant decrease (P<0.05) in its activity after 72 h of the induction of the inflammation was observed with all substrates.
characterization the SNPs in the promoter region of the bovine PON1 gene, and to evaluation of association with serum PON1 activity in periparturient Holstein cows
The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.
Data indicate that Cu(2+), Mn(2+), Zn(2+), Ni(2 (show VMP1 Antibodies)+), and Pb(2+) were found to inhibite the paraoxonase 1 (PON1) enzyme activity in a concentration-dependent fashion.
The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.
Significantly lower PON1 activity and PON1/high density lipoprotein ratio in lactating cows compared to heifers showed that metabolic efforts during pregnancy, parturition and lactation influence PON1 activity due to oxidative stress.
The activity of PON1 and malondialdehyde in late pregnancy and early lactation in dairy cattle is reported.
ApoE (show APOE Antibodies) mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Antibodies) paraoxonase activity
PON1 can decrease the AChE inhibition, and alleviated clinical signs and tissue damage caused by dichlorvos.
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.
, paraoxonase 2
, serum paraoxonase/arylesterase 1-like
, A-esterase 1
, PON 1
, aromatic esterase 1
, arylesterase B-type
, esterase A
, paraoxonase B-type
, serum aryldiakylphosphatase
, serum aryldialkylphosphatase 1
, serum paraoxonase/arylesterase 1
, serum paraoxonase