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The enzyme encoded by PON1 is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Additionally we are shipping Paraoxonase 1 Kits (62) and Paraoxonase 1 Proteins (27) and many more products for this protein.
Showing 10 out of 163 products:
Human Polyclonal PON1 Primary Antibody for EIA, FACS - ABIN954245
Cagirci, Cay, Karakurt, Durmaz, Yazihan, Canga, Aydin, Acikel, Kilic, Topaloglu, Aras, Demir, Akdemir: Paraoxonase activity might be predictive of the severity of aortic valve stenosis. in The Journal of heart valve disease 2010
Show all 3 references for ABIN954245
Human Polyclonal PON1 Primary Antibody for IHC, IHC (p) - ABIN4346826
Lescuyer, Pernin, Hainard, Bigeire, Burgess, Zimmermann-Ivol, Sanchez, Schifferli, Hochstrasser, Moll: Proteomic analysis of a podocyte vesicle-enriched fraction from human normal and pathological urine samples. in Proteomics. Clinical applications 2010
Show all 2 references for ABIN4346826
Human Monoclonal PON1 Primary Antibody for FACS, IHC - ABIN1724909
Saadat: Paraoxonase 1 genetic polymorphisms and susceptibility to breast cancer: a meta-analysis. in Cancer epidemiology 2012
Show all 2 references for ABIN1724909
Human Monoclonal PON1 Primary Antibody for ICC, FACS - ABIN1724910
Yesilova, Turan, Ucmak, Selek, Halil Yavuz, Tanr?kulu: Reduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress. in Redox report : communications in free radical research 2012
Show all 2 references for ABIN1724910
Cow (Bovine) Polyclonal PON1 Primary Antibody for IHC, WB - ABIN2776787
Penco, Buscema, Patrosso, Marocchi, Grossi: New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. in BMC bioinformatics 2008
Human Polyclonal PON1 Primary Antibody for ELISA, WB - ABIN439721
Bhattacharyya, Nicholls, Topol, Zhang, Yang, Schmitt, Fu, Shao, Brennan, Ellis, Brennan, Allayee, Lusis, Hazen: Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. in JAMA 2008
Human Polyclonal PON1 Primary Antibody for FACS, IHC (p) - ABIN654641
Guglielmetti, Mazza, Pagano, Carrella, Sciuto, Nodari, Pezzolato, Richelmi, Baioni, Caramelli, Acutis, Bozzetta: Identification by a proteomic approach of a plasma protein as a possible biomarker of illicit dexamethasone treatment in veal calves. in Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 2014
Cow (Bovine) Polyclonal PON1 Primary Antibody for WB - ABIN2776789
Rosenblat, Gaidukov, Khersonsky, Vaya, Oren, Tawfik, Aviram: The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux. in The Journal of biological chemistry 2006
The present study determined that ARE, CLP (show CALML3 Antibodies), CAT, and MPO (show MPO Antibodies) levels are different between the pediatric patients with sepsis and healthy controls. ARE level can be a potent biomarker for sepsis in critical patients in intensive care units.
A decrease in PON1 activity and increase in 8-isoprostane serum activities in patients may indicate the importance of lipid peroxidation in MM disease. Oxidative stress and especially lipid peroxidation could reduce the antioxidant activity of PON1 and ARE in MM patients and could be considered as factors in the pathogenesis of MM disease.
patients with renal failure have differences in the lipid profile compared to chronic kidney disease patients on hemodialysis, and these differences affect serum PON1 concentration; the decrease of serum PON1 concentration is influenced by the lipid profile of CKD patients
This study demonstrated that PON1 polymorphisms L55M and Q192R seem to be genetic markers involved in the development of diabetic nephropathy in youth with type 1 diabetes.
Our results confirm the relationship between variations in PON1 activities and lipid metabolism, and showed that genetically programmed low PON1 activities would have certain responsibility in the increase in glycemia and concomitantly the aggravation of atherosclerotic disease
PON1 polymorphism might be one of the genetic factors of longevity in the Bama Zhuang population.
First study in the literature to show an association between paraoxonase-1 activity and thyroid hormone (show PTH Antibodies) concentration and neural tube defects.
Apo A (show APOA Antibodies)-I and paraoxonase-1 levels may be clinically useful for ischemic stroke diagnosis and for differentiating between ischemic and hemorrhagic strokes.
PON1 overexpression protects against AAA (show APP Antibodies) progression by reducing oxidative stress, apoptosis and inflammation
FGF-23 (show FGF23 Antibodies) and PON1 lactonase have roles in native AV fistula thrombosis in hemodialysis patients
PON1 overexpression protects against AAA (show AAAS Antibodies) progression by reducing oxidative stress, apoptosis and inflammation
Paraoxonase 1 (PON1) influence circadian gene expression and period length
results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL (show HSD11B1 Antibodies), owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis.
Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes.
5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1.
HDL (show HSD11B1 Antibodies) (mostly HDL3), stimulates PON1 antiatherogenic activities in mouse macrophages.
Findings suggest that Pon1 interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis
The study demonstrated a significant decline in PON1 activity which correlates with increased LDL oxidation after 8 months of age in Wistar rats.
PON1 plays a protective role against hepatic derangements, secondary to fat and cholesterol overnutrition. PON1 deficiency is associated with oxidative stress and metabolic alterations leading to liver steatosis.
PON1 is not essential for normal development, function, ageing, and the defense against light damage of the mouse retina.
PON1 behaves as a negative acute phase protein (show ORM1 Antibodies) in pigs since a significant decrease (P<0.05) in its activity after 72 h of the induction of the inflammation was observed with all substrates.
characterization the SNPs in the promoter region of the bovine PON1 gene, and to evaluation of association with serum PON1 activity in periparturient Holstein cows
The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.
Data indicate that Cu(2+), Mn(2+), Zn(2+), Ni(2 (show VMP1 Antibodies)+), and Pb(2+) were found to inhibite the paraoxonase 1 (PON1) enzyme activity in a concentration-dependent fashion.
The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.
Significantly lower PON1 activity and PON1/high density lipoprotein ratio in lactating cows compared to heifers showed that metabolic efforts during pregnancy, parturition and lactation influence PON1 activity due to oxidative stress.
The activity of PON1 and malondialdehyde in late pregnancy and early lactation in dairy cattle is reported.
ApoE (show APOE Antibodies) mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Antibodies) paraoxonase activity
PON1 can decrease the AChE inhibition, and alleviated clinical signs and tissue damage caused by dichlorvos.
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.
, paraoxonase 2
, serum paraoxonase/arylesterase 1-like
, A-esterase 1
, PON 1
, aromatic esterase 1
, arylesterase B-type
, esterase A
, paraoxonase B-type
, serum aryldiakylphosphatase
, serum aryldialkylphosphatase 1
, serum paraoxonase/arylesterase 1
, serum paraoxonase