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PON3 is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. Additionally we are shipping Paraoxonase 3 Kits (15) and Paraoxonase 3 Proteins (5) and many more products for this protein.
Showing 10 out of 72 products:
Human Polyclonal PON3 Primary Antibody for EIA, WB - ABIN453785
Precourt, Seidman, Delvin, Amre, Deslandres, Dominguez, Sinnett, Levy: Comparative expression analysis reveals differences in the regulation of intestinal paraoxonase family members. in The international journal of biochemistry & cell biology 2009
Show all 2 references for ABIN453785
Human Polyclonal PON3 Primary Antibody for IHC, WB - ABIN2777017
Sanghera, Manzi, Minster, Shaw, Kao, Bontempo, Kamboh: Genetic variation in the paraoxonase-3 (PON3) gene is associated with serum PON1 activity. in Annals of human genetics 2008
The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1 (show PON1 Antibodies), 2 and 3 in granulosa cells and PON1 (show PON1 Antibodies) activity in follicular fluid and plasma of dairy cows.
Low PON3 expression is associated with hepatocellular carcinoma progression.
This study showed that the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway is up-regulated by the expression of PON3 in oral squamous cell carcinoma by AP-1 (show FOSB Antibodies).
Studies indicate that three paraoxonases PON1 (show PON1 Antibodies), PON2 (show PON2 Antibodies), and PON3 genes are clustered on chromosome 7, and that PONs possess numerous atheroprotective properties.
PON3 SNP rs13226149 was associated with intracerebral hemorrhage in log-additive and dominant models. The A allele of rs13226149 contributed to the decreased risk of ICH (show COL4a2 Antibodies). SNP rs1053275 was not associated with ICH (show COL4a2 Antibodies).
Data suggest cigarette smoke leads to inhibition of hydrolytic activity of paraoxonase isoenzymes (PON1 (show PON1 Antibodies), PON2 (show PON2 Antibodies), PON3) by modification of thiol groups, by interactions with free radicals/heavy metals, or by decreasing HDL (show HSD11B1 Antibodies) level in blood. [REVIEW]
Interaction of PON-3 and PON-1 (show PON1 Antibodies) and HDL (show HSD11B1 Antibodies) are associated with the presence and severity of coronary artery disease in type 2 diabetes mellitus patients.
PON3 in HDL (show HSD11B1 Antibodies) may be an important protein in preventing atherosclerosis.
PON2 (show PON2 Antibodies) and PON3 (i) are associated with mitochondria and mitochondria-associated membranes, (ii) modulate mitochondria-dependent superoxide production, and (iii) prevent apoptosis.
PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.
Our results suggest that low serum paraoxonase activity is a risk factor for Alzheimer disease. Furthermore, multiple variants in PON (show PON1 Antibodies) influence serum paraoxonase activity and their effects may be synergistic.
study suggests a role for PON3 in the metabolism of lipid and bile acid as well as protection against atherosclerosis, gallstone disease, and obesity
investigation of effect of knockout of Pon3 in embryo: Data suggest that Pon3-/- mice exhibit increased early embryonic and neonatal mortality.
mouse Pon3 is expressed in a wide range of tissues, and that its expression is temporally controlled
PON3 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.
The anti-atherogenic biological activities were studied in vitro using serum or cell cultures, and also in vivo, using PON 1 (show PON1 Antibodies)/2/3 knockout or transgenic mice, as well as humans - healthy volunteers and atherosclerotic patients.
The directed evolution and characterization of recombinant variants of serum paraoxonase PON3, is described.
Results show that PON3 mRNA and protein are ubiquitously expressed in pig tissues. Moreover, the relative abundance of PON3 mRNA, measured in perirenal and subcutaneous fat tissues, is higher in obese gilts compared with the leaner (show CACNA1A Antibodies) gilts.
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described\; however, only one has been fully characterized.
, serum paraoxonase/lactonase 3-like
, serum paraoxonase/lactonase 3