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PON3 is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. Additionally we are shipping Paraoxonase 3 Antibodies (71) and Paraoxonase 3 Proteins (5) and many more products for this protein.
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The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1 (show PON1 ELISA Kits), 2 and 3 in granulosa cells and PON1 (show PON1 ELISA Kits) activity in follicular fluid and plasma of dairy cows.
Studies indicate that three paraoxonases PON1 (show PON1 ELISA Kits), PON2 (show PON2 ELISA Kits), and PON3 genes are clustered on chromosome 7, and that PONs possess numerous atheroprotective properties.
PON3 SNP rs13226149 was associated with intracerebral hemorrhage in log-additive and dominant models. The A allele of rs13226149 contributed to the decreased risk of ICH (show COL4a2 ELISA Kits). SNP rs1053275 was not associated with ICH (show COL4a2 ELISA Kits).
Data suggest cigarette smoke leads to inhibition of hydrolytic activity of paraoxonase isoenzymes (PON1 (show PON1 ELISA Kits), PON2 (show PON2 ELISA Kits), PON3) by modification of thiol groups, by interactions with free radicals/heavy metals, or by decreasing HDL (show HSD11B1 ELISA Kits) level in blood. [REVIEW]
Interaction of PON-3 and PON-1 (show PON1 ELISA Kits) and HDL (show HSD11B1 ELISA Kits) are associated with the presence and severity of coronary artery disease in type 2 diabetes mellitus patients.
PON3 in HDL (show HSD11B1 ELISA Kits) may be an important protein in preventing atherosclerosis.
PON2 (show PON2 ELISA Kits) and PON3 (i) are associated with mitochondria and mitochondria-associated membranes, (ii) modulate mitochondria-dependent superoxide production, and (iii) prevent apoptosis.
PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.
Our results suggest that low serum paraoxonase activity is a risk factor for Alzheimer disease. Furthermore, multiple variants in PON (show PON1 ELISA Kits) influence serum paraoxonase activity and their effects may be synergistic.
Increased serum paraoxonase-3 concentration is associated with insulin (show INS ELISA Kits) sensitivity in peripheral artery disease and with inflammation in coronary artery disease.
This study reports for the first time an important increase in serum PON3 concentrations in HIV-infected patients that is associated with their oxidative status and their treatment with NNRTI.
study suggests a role for PON3 in the metabolism of lipid and bile acid as well as protection against atherosclerosis, gallstone disease, and obesity
investigation of effect of knockout of Pon3 in embryo: Data suggest that Pon3-/- mice exhibit increased early embryonic and neonatal mortality.
mouse Pon3 is expressed in a wide range of tissues, and that its expression is temporally controlled
PON3 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.
The anti-atherogenic biological activities were studied in vitro using serum or cell cultures, and also in vivo, using PON 1 (show PON1 ELISA Kits)/2/3 knockout or transgenic mice, as well as humans - healthy volunteers and atherosclerotic patients.
The directed evolution and characterization of recombinant variants of serum paraoxonase PON3, is described.
Results show that PON3 mRNA and protein are ubiquitously expressed in pig tissues. Moreover, the relative abundance of PON3 mRNA, measured in perirenal and subcutaneous fat tissues, is higher in obese gilts compared with the leaner (show CACNA1A ELISA Kits) gilts.
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described\; however, only one has been fully characterized.
, serum paraoxonase/lactonase 3-like
, serum paraoxonase/lactonase 3