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Paraoxonase 3 Proteins (PON3)

PON3 is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. Additionally we are shipping Paraoxonase 3 Antibodies (66) and Paraoxonase 3 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PON3 5446 Q15166
PON3 269823 Q62087
Rat PON3 PON3 312086 Q68FP2
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Top Paraoxonase 3 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,960.83
Details

PON3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced Paraoxonase 3 Proteins

  1. Human PON3 Protein expressed in Baculovirus infected Insect Cells - ABIN2005397 : Dalrymple, Arber: The characterization of terminators of RNA transcription on IS30 and an analysis of their role in IS element-mediated polarity. in Gene 1986 (PubMed)
    Show all 2 references for ABIN2005397

More Proteins for Paraoxonase 3 (PON3) Interaction Partners

Cow (Bovine) Paraoxonase 3 (PON3) interaction partners

  1. The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1 (show PON1 Proteins), 2 and 3 in granulosa cells and PON1 (show PON1 Proteins) activity in follicular fluid and plasma of dairy cows.

Human Paraoxonase 3 (PON3) interaction partners

  1. PON3 SNP rs13226149 was associated with intracerebral hemorrhage in log-additive and dominant models. The A allele of rs13226149 contributed to the decreased risk of ICH (show COL4a2 Proteins). SNP rs1053275 was not associated with ICH (show COL4a2 Proteins).

  2. Data suggest cigarette smoke leads to inhibition of hydrolytic activity of paraoxonase isoenzymes (PON1 (show PON1 Proteins), PON2 (show PON2 Proteins), PON3) by modification of thiol groups, by interactions with free radicals/heavy metals, or by decreasing HDL (show HSD11B1 Proteins) level in blood. [REVIEW]

  3. Interaction of PON-3 and PON-1 (show PON1 Proteins) and HDL (show HSD11B1 Proteins) are associated with the presence and severity of coronary artery disease in type 2 diabetes mellitus patients.

  4. PON3 in HDL (show HSD11B1 Proteins) may be an important protein in preventing atherosclerosis.

  5. PON2 (show PON2 Proteins) and PON3 (i) are associated with mitochondria and mitochondria-associated membranes, (ii) modulate mitochondria-dependent superoxide production, and (iii) prevent apoptosis.

  6. PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.

  7. Our results suggest that low serum paraoxonase activity is a risk factor for Alzheimer disease. Furthermore, multiple variants in PON (show PON1 Proteins) influence serum paraoxonase activity and their effects may be synergistic.

  8. Increased serum paraoxonase-3 concentration is associated with insulin (show INS Proteins) sensitivity in peripheral artery disease and with inflammation in coronary artery disease.

  9. This study reports for the first time an important increase in serum PON3 concentrations in HIV-infected patients that is associated with their oxidative status and their treatment with NNRTI.

  10. investigation of whether gene silencing of Pon3 causes oxidative stress in cell line: Data suggest that PON3 knockdown reduces cell proliferation and total antioxidant capacity at ambient oxygen levels.

Mouse (Murine) Paraoxonase 3 (PON3) interaction partners

  1. study suggests a role for PON3 in the metabolism of lipid and bile acid as well as protection against atherosclerosis, gallstone disease, and obesity

  2. PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.

  3. investigation of effect of knockout of Pon3 in embryo: Data suggest that Pon3-/- mice exhibit increased early embryonic and neonatal mortality.

  4. mouse Pon3 is expressed in a wide range of tissues, and that its expression is temporally controlled

  5. PON3 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.

  6. The anti-atherogenic biological activities were studied in vitro using serum or cell cultures, and also in vivo, using PON 1 (show PON1 Proteins)/2/3 knockout or transgenic mice, as well as humans - healthy volunteers and atherosclerotic patients.

  7. The directed evolution and characterization of recombinant variants of serum paraoxonase PON3, is described.

Rabbit Paraoxonase 3 (PON3) interaction partners

  1. The directed evolution and characterization of recombinant variants of serum paraoxonase PON3, is described.

Pig (Porcine) Paraoxonase 3 (PON3) interaction partners

  1. Results show that PON3 mRNA and protein are ubiquitously expressed in pig tissues. Moreover, the relative abundance of PON3 mRNA, measured in perirenal and subcutaneous fat tissues, is higher in obese gilts compared with the leaner (show CACNA1A Proteins) gilts.

Paraoxonase 3 (PON3) Protein Profile

Protein Summary

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described\; however, only one has been fully characterized.

Gene names and symbols associated with Paraoxonase 3 Proteins (PON3)

  • paraoxonase 3 (PON3)
  • paraoxonase 3 (Pon3)
  • 2810004E20 protein
  • AI786302 protein

Protein level used designations for Paraoxonase 3 Proteins (PON3)

paraoxonase 3 , serum paraoxonase/lactonase 3-like , serum paraoxonase/lactonase 3 , paraoxanase-3

GENE ID SPECIES
699236 Macaca mulatta
100337686 Ovis aries
100408549 Callithrix jacchus
100436262 Pongo abelii
100603110 Nomascus leucogenys
463548 Pan troglodytes
510953 Bos taurus
5446 Homo sapiens
269823 Mus musculus
312086 Rattus norvegicus
100008754 Oryctolagus cuniculus
475235 Canis lupus familiaris
733674 Sus scrofa
100721546 Cavia porcellus
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