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PSPC1 encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. Additionally we are shipping Paraspeckle Component 1 Proteins (3) and many more products for this protein.
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The crystal structure of the heterodimer of the multidomain conserved region of the Drosophila behavior/human splicing proteins, PSPC1 and NONO (show NONO Antibodies), is described.
downregulated were the a protein coding gene PSPC1 in breast and ovarian cancer cells
crystal of PSPC1-NONO (show NONO Antibodies) contained one heterodimer in the asymmetric unit and diffracted to 1.9 A resolution using synchrotron radiation
We map the domain within PSP1 that is mediating this interaction and show it is required for the correct localization of PSP1 to paraspeckles. This interaction is necessary but not sufficient for paraspeckle targeting by PSP1
Specific interaction with the nuclear transporter (show RPAIN Antibodies) importin (show KPNA4 Antibodies) alpha2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles.
NONO (show NONO Antibodies) genetic insufficiency led to upregulation of PSPC1, which replaced NONO (show NONO Antibodies) in a stable complex with SFPQ (show SFPQ Antibodies).
A protein complex was identified containing PSPC1, PSF (show IL-3 Antibodies) and LMX1B (show LMX1B Antibodies), suggesting the existence of this complex in mesodiencephalic dopaminergic neurons.
mPSP1 may regulate multiple phases of important nuclear events during spermatogenesis.
PSPC1, NONO (show NONO Antibodies), and SFPQ (show SFPQ Antibodies) form complexes with each other in Sertoli cells and may regulate androgen receptor (show AR Antibodies)-mediated transcriptional activity
This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified.
paraspeckle component 1
, paraspeckle protein 1