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Parathyroid Hormone 1 Receptor Proteins (PTH1R)

The protein encoded by PTH1R is a member of the G-protein coupled receptor family 2. Additionally we are shipping PTH1R Antibodies (74) and PTH1R Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTH1R 5745 Q03431
PTH1R 19228 P41593
Rat PTH1R PTH1R 56813 P25961
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Top PTH1R Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details
HOST_Human Human His tag   10 μg Log in to see 5 Days
$137.50
Details

PTH1R Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, ,
Mouse (Murine) ,
,

Top referenced PTH1R Proteins

  1. Human PTH1R Protein expressed in Human Cells - ABIN2005129 : Schipani, Karga, Karaplis, Potts, Kronenberg, Segre, Abou-Samra, Jüppner: Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. in Endocrinology 1993 (PubMed)
    Show all 4 references for ABIN2005129

  2. Human PTH1R Protein expressed in HEK-293 Cells - ABIN2181675 : Johnston, Kimple, Giguère, Siderovski: Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2. in Structure (London, England : 1993) 2008 (PubMed)
    Show all 3 references for ABIN2181675

More Proteins for Parathyroid Hormone 1 Receptor (PTH1R) Interaction Partners

Zebrafish Parathyroid Hormone 1 Receptor (PTH1R) interaction partners

  1. Loss of function of either PTHR1 or PTHrP in zebrafish leads to a localized aortic defect that is Notch (show NOTCH1 Proteins) dependent.

Human Parathyroid Hormone 1 Receptor (PTH1R) interaction partners

  1. A Homozygous [Cys25]PTH(1-84) Mutation That Impairs PTH/PTHrP Receptor Activation Defines a Novel Form of Hypoparathyroidism.

  2. Data suggest affinity of ligands for binding site on PTHR1, either in GTP-binding protein-dependent or -independent conformation, alters duration of action of ligand in target cells; ligands were fragments of PTHRP/parathyroid hormone-related protein.

  3. This Review discusses current understanding of PTHR1 modes of action and how these findings might be applied in future therapeutic agents--{REVIEW}

  4. We show that sustained stimulation with PTH (show PTH Proteins) leads to diminished potentiation of carbachol-evoked Ca2 (show CA2 Proteins)+ signals. This does not require internalization of PTH1R.

  5. data indicate that, albeit the similarity in its subcellular distribution, PTH1R in PDL cells exhibits characteristics different from those in MG63 cells, pointing to the cell type specificity of this receptor

  6. data significantly increase the number of presently known unique PFE-causing PTH1R mutations and provide a series of variants with unclear pathogenicity which will require further in vitro assaying to determine effects on protein structure and function

  7. Disruption of beta-catenin (show CTNNB1 Proteins) binding to parathyroid hormone (PTH (show PTH Proteins)) receptor PTH1R inhibits PTH (show PTH Proteins)-stimulated ERK1/2 activation.

  8. PTHR1 signaling is important in maintaining osteosarcoma proliferation and undifferentiated state.

  9. salt bridge between Arg-20 on parathyroid hormone (PTH (show PTH Proteins)) and Asp (show ASIP Proteins)-137 on the PTH1 receptor is essential for full affinity.

  10. Treatment of recipient HEK (show EPHA3 Proteins) 293a cells transiently expressing PTH1R with PTH (show PTH Proteins)-myc (show MYC Proteins) CM allowed the labeling of endosomal structures positive for Rab5 (show RAB5A Proteins) and/or for beta-arrestin1 (show ARRB1 Proteins).

Mouse (Murine) Parathyroid Hormone 1 Receptor (PTH1R) interaction partners

  1. we propose that PTH (show PTH Proteins) has a direct effect on osteoblasts and osteoclasts, and that this effect is mediated through PTH1R, thus contributing to bone remodeling

  2. Ihh (show IHH Proteins) and PTH1R signaling in limb mesenchyme are both essential to regulate proper development of digit structures, although they appear to use different mechanisms.

  3. cells expressing osterix (show SP7 Proteins) are mesenchymal progenitors contributing to all relevant cell types during morphogenesis.

  4. PTH1R regulates systemic mineral ion homeostasis and induction of FGF23 (show FGF23 Proteins).

  5. PTH1R is an important component of mechanical signal transduction in osteocytic MLO-Y4 cells.

  6. These studies reveal that PTH1R signaling in osteoblasts regulates cartilaginous growth plate for postnatal growth of bone.

  7. Cbfbeta (show CBFB Proteins) functions in upregulating Ihh (show IHH Proteins) expression to promoter chondrocyte proliferation and osteoblast differentiation, and inhibiting PPR expression to enhance chondrocyte differentiation.

  8. Osteocytic gp130 (show LRPPRC Proteins) is required to maintain PTH1R expression in the osteoblast lineage, and for the stimulation of osteoblast differentiation that occurs in response to PTH (show PTH Proteins).

  9. PTH (show PTH Proteins) receptor signaling enhances bone resorption by directly regulating Rankl (show TNFSF11 Proteins) gene expression in osteocytes.

  10. Data suggest that parathyroid hormone (PTH (show PTH Proteins)) receptor signaling could enhance the therapeutic potential of the pathway.

Cow (Bovine) Parathyroid Hormone 1 Receptor (PTH1R) interaction partners

  1. The expression of the PTH/PTHrP receptor in dairy cows before and after parturition is reported.

Pig (Porcine) Parathyroid Hormone 1 Receptor (PTH1R) interaction partners

  1. This study reveals clear genetic-statistical evidence for a link of KRT8 (show KRT8 Proteins), FAF1 (show FAF1 Proteins) and PTH1R with some of leg weakness related traits in pigs.

  2. These findings reveal that direct ezrin interactions promote PTH1R apical localization and signaling in LLC-PK1 cells.

  3. PTHLH and PTHR1 were evaluated as functional candidate genes for their effects on number and shape of teats in pigs

PTH1R Protein Profile

Protein Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with PTH1R

  • parathyroid hormone 1 receptor a (pth1ra)
  • parathyroid hormone 1 receptor (PTH1R)
  • parathyroid hormone 1 receptor (Pth1r)
  • PFE protein
  • PPR protein
  • PTH protein
  • PTH1 protein
  • Pthr protein
  • Pthr1 protein
  • PTHrel protein
  • zPTH1R protein

Protein level used designations for PTH1R

parathyroid hormone receptor 1 , parathyroid hormone/parathyroid hormone-related peptide receptor , parathyroid hormone 1 receptor , PTH/PTHr receptor , PTH/PTHrP type I receptor , PTH1 receptor , Parathyroid hormone/parathyroid hormone-related peptide receptor , parathyroid hormone/parathyroid hormone-related peptide receptor-like , parathyroid hormone/parathyroid hormone-related protein receptor , seven transmembrane helix receptor , PTH-related peptide receptor , PTH/PTHrP receptor , parathyroid hormone receptor-1 , parathyroid receptor

GENE ID SPECIES
30629 Danio rerio
420401 Gallus gallus
461008 Pan troglodytes
712147 Macaca mulatta
100054278 Equus caballus
100190839 Pongo abelii
100402780 Callithrix jacchus
5745 Homo sapiens
19228 Mus musculus
56813 Rattus norvegicus
507783 Bos taurus
403779 Canis lupus familiaris
397675 Sus scrofa
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