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Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) ELISA Kits

The precise function of PARK2 is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Additionally we are shipping PARK2 Antibodies (211) and PARK2 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PARK2 50873 Q9WVS6
PARK2 56816 Q9JK66
PARK2 5071 O60260
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Top PARK2 ELISA Kits at antibodies-online.com

Showing 5 out of 17 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 0.78 pg/mL 3.12-200 pg/mL Typical standard curve 96 Tests Log in to see 11 to 13 Days
$910.56
Details
Human 0.053 ng/mL 0.15-10 ng/mL   96 Tests Log in to see 9 to 11 Days
$810.53
Details
Goat 0.1 ng/mL 2.5-50 ng/mL   96 Tests Log in to see 11 to 13 Days
$707.14
Details
Human
  96 Tests Log in to see 11 Days
$848.18
Details
Rat
  96 Tests Log in to see 11 to 13 Days
$875.60
Details

More ELISA Kits for PARK2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Parkin-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  2. We demonstrate here that vps35 (show vps35 ELISA Kits) genetically interacts with parkin

  3. Clu directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.

  4. Human Mask homolog ANKHD1 (show ANKHD1 ELISA Kits) may serve as a potential therapeutic target for treating Parkinson disease caused by pink1/parkin mutations.

  5. These results indicate that the in vivo rescue is due to restoring CI activity rather than promoting mitophagy Our findings support the emerging view that PINK1 plays a role in regulating CI activity separate from its role with Parkin in mitophagy

  6. MUL1 acts in parallel to the PINK1/parkin pathway on a shared target mitofusin (show MFN2 ELISA Kits) to maintain mitochondrial integrity.

  7. Parkin cooperates with PINK1 to promote hnRNP-F/Glo ubiquitination and nRCC mRNA translation.

  8. The loss-of-function mutation in parkin results in defective immune response against bacterial infection. Additionally, parkin mutant larvae showed hypersensitivity against wound regardless of bacterial infection.

  9. data thus support the potential of folic acid in alleviating the behavioural defects, oxidative stress, augmentation of zinc and ATP levels in parkin knock down flies

  10. Parkin phosphorylation by PINK1 drives Parkin E3 activity. endogenous PINK1 precisely controls Parkin activity to maintain the mitochondrial function in muscle tissue and the neuronal function in dopaminergic neurons.

Mouse (Murine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Parkin protects against oxygen-glucose deprivation/reperfusion insult by promoting degradation of Drp1 (show CRMP1 ELISA Kits).

  2. The identification of PINK1 and Parkin as suppressors of an immune-response-eliciting pathway provoked by inflammation suggests new insights into Parkinson's disease pathology.

  3. p62 (show GTF2H1 ELISA Kits) are subjected to parkin mediated proteasomal degradation

  4. A comprehensive analysis of influence of the Parkinson disease-associated genes Parkin and DJ-1 (show PARK7 ELISA Kits) on neurotransmitter receptor (show GRIN1 ELISA Kits) expression in mice

  5. Whereas Parkin has been reported to positively regulate the expression of OPA1 (show MED12 ELISA Kits) through NEMO (show IKBKG ELISA Kits), herein we found that PARK2 overexpression did not modify the expression of OPA1 (show MED12 ELISA Kits).

  6. In mouse hearts Parkin functions as a stress-induced and developmentally-programmed facilitator of cardiomyocyte mitochondrial turnover. (Review)

  7. findings support the notion that BAG2 (show BAG2 ELISA Kits) is an upstream regulator of the PINK1/PARKIN signaling pathway.

  8. The PINK1-Parkin pathway is activated in response to metabolic stress

  9. Overexpressed human wild type alpha-synuclein (show SNCA ELISA Kits) in the substantia nigra was phosphorylated at Ser (show SIGLEC1 ELISA Kits) 129 significantly more in parkin knockout mice, though the total alpha synuclein (show SNCA ELISA Kits) levels were the same as in wild type mice.

  10. analysis of two types of mitophagy, a DNM1L (show DNM1L ELISA Kits)-dependent pathway and a PARK2-dependent pathway

Human Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Study analysed mis (show AMH ELISA Kits)-sense mutations spanning the Parkin RING2 (show RNF2 ELISA Kits) and adjoining REP domain to study the structure-function relationship of human Parkin. The mutations except P437L and A379V resulted in protein structure deformation and functional loss of Parkin.

  2. Parkin is downregulated under hypoxia and that it interferes with HIF expression based on cellular oxygen tension.

  3. SNP rs10945859 in the PARK2 gene could prove useful in predicting the clinical outcome in HCV-infected patients.

  4. Patients with Parkin compound heterozygous mutations have relatively preserved olfaction compared to Parkin single heterozygotes and non-carriers

  5. This study showed that LRRK2 (show LRRK2 ELISA Kits), PARK2 and ATP13A2 (show ATP13A2 ELISA Kits) are under copy number variations influence in patient with Parkinson disease.

  6. Our results using the multivariate analysis between the additive and dominant model demonstrated that tag SNP rs2803073 of PARK2 is associated with susceptibility to epithelial ovarian cancer (p = 0.018, OR = 0.42).

  7. Exonic duplication might result in a more severe interference of PARK2 expression and the clinical feature than deletion at the A region (exons 2-4) of the PARK2 locus.

  8. parkin influences the spatial organization of actin filaments, the shape of human fibroblasts, and their elastic response to an external applied force

  9. this study results may reveal a unique genetic-environmental interactions contributing to the disease mechanism of a PD patient carrying Ex5del in PARK2

  10. Pedigree of Parkinson's disease family indicating consanguineous marriages as well as two sequence variants identified in the Parkin gene

Pig (Porcine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Single nucleotide polymorphism (SNP) analysis revealed seven SNPs in the porcine PARK2 gene, one missense and one silent mutation in exon 7 and five SNPs in intron 7

PARK2 Antigen Profile

Antigen Summary

The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Gene names and symbols associated with PARK2

  • parkin (park) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2) antibody
  • parkin (CpipJ_CPIJ014867) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (LOC100150461) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (Park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (Park2) antibody
  • AR-JP antibody
  • CG10523 antibody
  • Dmel\\CG10523 antibody
  • Dpark antibody
  • dpk antibody
  • LOC100150461 antibody
  • LPRS2 antibody
  • Park antibody
  • PDJ antibody
  • pdr-1 antibody
  • Prkn antibody
  • SD01679 antibody
  • si:ch211-123f21.1 antibody
  • zgc:112390 antibody

Protein level used designations for PARK2

CG10523-PB , CG10523-PC , D-parkin , dparkin , park-PB , park-PC , E3 ubiquitin-protein ligase parkin , parkin , Parkinson disease (autosomal recessive, juvenile) 2, parkin , parkin protein , parkin variant SV5DEL , parkinson juvenile disease protein 2

GENE ID SPECIES
40336 Drosophila melanogaster
550328 Danio rerio
741350 Pan troglodytes
6049109 Culex quinquefasciatus
100150461 Danio rerio
50873 Mus musculus
56816 Rattus norvegicus
5071 Homo sapiens
612316 Canis lupus familiaris
733673 Sus scrofa
100724550 Cavia porcellus
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