Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) Proteins (PARK2)

The precise function of PARK2 is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Additionally we are shipping PARK2 Antibodies (178) and PARK2 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PARK2 50873 Q9WVS6
PARK2 56816 Q9JK66
PARK2 5071 O60260
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Top PARK2 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$225.00
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,309.17
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HOST_Insect cells (Sf21) Human Un-conjugated   25 μg Log in to see 5 to 8 Days
$722.40
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HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$388.93
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HOST_Escherichia coli (E. coli) Human S tag,His tag   100 μg Log in to see 15 to 18 Days
$624.00
Details

PARK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , , , ,
, ,

More Proteins for Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Maintenance of tissue homeostasis upon reduction of Pink1 (show PINK1 Proteins) or Parkin appears to result from reduction of age- and stress-induced intestinal stem cell proliferation, in part, through induction of ISC senescence.

  2. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 (show PINK1 Proteins) and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  3. Pharmacological or genetic activation of heat shock protein 70 (Hsp70) protects against loss of parkin Function. Heat shock protein members may act as compensatory factors for parkin loss of function and that the exploitation of these factors may be of potential therapeutic value.

  4. autophosphorylation of PINK1 (show PINK1 Proteins) is essential for the mitochondrial translocation of Parkin and for subsequent phosphorylation and activation of Parkin.

  5. Our data indicate that PINK1 (show PINK1 Proteins) and Parkin play an important role in FUS (show FUS Proteins)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (show FUS Proteins) proteinopathy and PINK1 (show PINK1 Proteins)/Parkin genes, providing new insights into the pathogenesis of FUS (show FUS Proteins) proteinopathy.

  6. Clu (show CLU Proteins) is upstream of and binds to VCP (show vcp Proteins) in vivo and promotes VCP (show vcp Proteins)-dependent Marf (show MFN2 Proteins) degradation in vitro Marf (show MFN2 Proteins) accumulates in whole muscle lysates of clu (show CLU Proteins)-deficient flies and is destabilized upon Clu (show CLU Proteins) overexpression. Thus, Clu (show CLU Proteins) is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP (show vcp Proteins) for Marf (show MFN2 Proteins) degradation to promote damaged mitochondrial clearance.

  7. Buffy has a role enhancing the loss of parkin and suppressing the loss of Pink1 (show PINK1 Proteins) phenotypes in Drosophila

  8. Parkin-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  9. We demonstrate here that vps35 (show vps35 Proteins) genetically interacts with parkin

  10. Clu (show CLU Proteins) directly modulates mitochondrial function, and that Clu's function contributes to the PINK1 (show PINK1 Proteins)-Park pathway of mitochondrial quality control.

Zebrafish Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Melatonin, added together with MPTP (show PTPN2 Proteins) or added once MPTP (show PTPN2 Proteins) was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1 (show PINK1 Proteins)/DJ-1 (show PARK7 Proteins)/MUL1 loop and also the normal motor activity of the embryos.

Mouse (Murine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. These findings suggest that insufficient mitophagy-mediated PDGFR (show PDGFRB Proteins)/PI3K/AKT (show AKT1 Proteins) activation, which is mainly attributed to reduced PARK2 expression, is a potent underlying mechanism for myofibroblast differentiation and proliferation in fibroblastic foci formation during idiopathic pulmonary fibrosis pathogenesis

  2. Mfn2 (show MFN2 Proteins) downregulation or the exogenous expression of normal Parkin restored cytosolic Ca(2 (show CA2 Proteins)+) transients in fibroblasts from patients with PARK2 mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin variant had no effect. Parkin is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin function in PD development

  3. Our results provide a molecular explanation for the contribution of Drp1 (show CRMP1 Proteins) to the pathogenesis of sporadic Parkinson's disease (PD). These findings indicate that the SNO-Parkin pathway may be a novel therapeutic target to treat PD

  4. These results suggest a previously unidentified role of parkin in mediating endotoxin-induced endothelial proinflammatory signaling and indicate that it may play a critical role in acute inflammation.

  5. These studies suggest that changes in intestinal lipid absorption may play a primary role in protection from nutritional stress in Park2 KO mice by preventing HFD-induced weight gain and highlight the need for tissue-specific models to address the role of PARK2 during metabolic stress.

  6. Parkin negatively regulates the number and connectivity of mitochondria via a Drp1-independent mechanism.

  7. Parkin-overexpressing cells also showed reductions in apoptotic BAX (show BAX Proteins) translocation to the mitochondria and cytochrome c (show CYCS Proteins) release to the cytosol

  8. Parkin protects against oxygen-glucose deprivation/reperfusion insult by promoting degradation of Drp1.

  9. The identification of PINK1 (show PINK1 Proteins) and Parkin as suppressors of an immune-response-eliciting pathway provoked by inflammation suggests new insights into Parkinson's disease pathology.

  10. p62 (show GTF2H1 Proteins) are subjected to parkin mediated proteasomal degradation

Human Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Adipogenic process can be dissected into 3 stages according to the participation of PARL (show PARL Proteins)-PINK1 (show PINK1 Proteins)-Parkin system. Findings reveal the sequential adipogenic events directed by PARL (show PARL Proteins)-PINK1 (show PINK1 Proteins)-Parkin system, add more evidence supporting the convergence of pathogenesis leading to neurodegenerative and metabolic disease

  2. These results highlight the combined effects of Parkin and PGC-1alpha in the maintenance of mitochondrial homeostasis in dopaminergic neurons. These two factors synergistically control the quality and function of mitochondria, which is important for the survival of neurons in Parkinson's disease.

  3. Data suggest that inactivation of cytosolic parkin in dopaminergic neurons of the substantia nigra contributes to neurodegeneration in sporadic Parkinson disease. [REVIEW]

  4. we identified a genome-wide significant association involving measures of midface height at 6q26 within an intron of PARK2

  5. PARK2 inactivation connects energy and oxidative stress to Akt activation via redox-mediated inactivation of PTEN by S-nitrosylation to support cell survival under conditions of energy deprivation.

  6. These results suggest that degradation of endogenous APE1 (show APEX1 Proteins) by Parkin occur when cells are stressed to activate Parkin, and imply a role of Parkin in maintaining the quality of APE1 (show APEX1 Proteins), and loss of Parkin may contribute to elevated APE1 (show APEX1 Proteins) levels in glioblastoma.

  7. Neurodegeneration in Parkinson's patients harboring homozygous loss-of-function mutations in the PARK2 gene may result from unbalanced levels of ROS (show ROS1 Proteins), which are mostly produced in mitochondria and can irreparably damage macromolecules and trigger apoptosis.

  8. These findings suggest that insufficient mitophagy-mediated PDGFR (show PDGFRB Proteins)/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) activation, which is mainly attributed to reduced PARK2 expression, is a potent underlying mechanism for myofibroblast differentiation and proliferation in fibroblastic foci formation during idiopathic pulmonary fibrosis pathogenesis

  9. PKA-mediated phosphorylation of MIC60 negatively regulates mitochondrial clearance that is initiated by PINK1 (show PINK1 Proteins) and Parkin.

  10. Mfn2 (show MFN2 Proteins) downregulation or the exogenous expression of normal Parkin restored cytosolic Ca(2 (show CA2 Proteins)+) transients in fibroblasts from patients with PARK2 mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin variant had no effect. Parkin is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin function in PD development

Pig (Porcine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Single nucleotide polymorphism (SNP) analysis revealed seven SNPs in the porcine PARK2 gene, one missense and one silent mutation in exon 7 and five SNPs in intron 7

PARK2 Protein Profile

Protein Summary

The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Gene names and symbols associated with PARK2

  • parkin (park)
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (park2)
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2)
  • parkin (CpipJ_CPIJ014867)
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (LOC100150461)
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2)
  • parkinson protein 2, E3 ubiquitin protein ligase (Park2)
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (Park2)
  • AR-JP protein
  • CG10523 protein
  • Dmel\\CG10523 protein
  • Dpark protein
  • dpk protein
  • LOC100150461 protein
  • LPRS2 protein
  • Park protein
  • PDJ protein
  • pdr-1 protein
  • Prkn protein
  • SD01679 protein
  • si:ch211-123f21.1 protein
  • zgc:112390 protein

Protein level used designations for PARK2

CG10523-PB , CG10523-PC , D-parkin , dparkin , park-PB , park-PC , E3 ubiquitin-protein ligase parkin , parkin , Parkinson disease (autosomal recessive, juvenile) 2, parkin , parkin protein , parkin variant SV5DEL , parkinson juvenile disease protein 2

GENE ID SPECIES
40336 Drosophila melanogaster
550328 Danio rerio
741350 Pan troglodytes
6049109 Culex quinquefasciatus
100150461 Danio rerio
50873 Mus musculus
56816 Rattus norvegicus
5071 Homo sapiens
612316 Canis lupus familiaris
733673 Sus scrofa
100724550 Cavia porcellus
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