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The product of PARK7 belongs to the peptidase C56 family of proteins. Additionally we are shipping PARK7 Antibodies (220) and PARK7 Proteins (26) and many more products for this protein.
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These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons.
A comprehensive analysis of influence of the Parkinson disease-associated genes Parkin (show PARK2 ELISA Kits) and DJ-1 on neurotransmitter receptor (show GRIN1 ELISA Kits) expression in mice
this study identified the anti-oxidant protein DJ-1 as being capable of protecting pancreatic islet cells from cell death induced by an inflammatory and cytotoxic setting.
In skeletal muscle cells, DJ-1 contributes to undernutrition-induced atrophy via MAPKs/ubiquitin ligase pathway.
Deficiency of DJ-1 exerts a stimulatory effect on vascular smooth muscle cell migration.
DJ1 maintains cellular metabolic homeostasis via modulating ROS (show ROS1 ELISA Kits) levels in murine skeletal muscles, revealing a role of DJ1 in maintaining efficient fuel utilization.
DJ-1 physically binds the 20S proteasome (show PSMA5 ELISA Kits) and inhibits its activity. following oxidative stress, DJ-1 is involved in the Nrf2 (show NFE2L2 ELISA Kits)-dependent oxidative stress response that leads to the upregulation of both the 20S proteasome (show PSMA5 ELISA Kits) and its regulator, NQO1 (show NQO1 ELISA Kits).
The Park7 has a protective role against sepsis by controlling macrophage activation, NADPH oxidase (show NOX1 ELISA Kits) activation and inflammation responses.
results suggest that legumain (show LGMN ELISA Kits) expression and activation and cleavage of annexin A2 (show ANXA2 ELISA Kits) are regulated by DJ-1 through p53 (show TP53 ELISA Kits)
in addition to detailing the visual defects that occur as a result of the absence of DJ-1, our data is also relevant to AMD (show AMD1 ELISA Kits) pathogenesis.
DJ-1 reinforces the PI3K/AKT (show AKT1 ELISA Kits) survival pathway and inhibits autophagy, probably by a mechanism independent from mTOR (show FRAP1 ELISA Kits).
DJ-1 deglycase plays a major role in preventing protein glycation in eukaryotic cells and might be important for preventing skin glycation
S. pombe homologs of DJ-1 are stationary-phase associated proteins.
these findings demonstrate that SETD6 (show SETD6 ELISA Kits) negatively regulates the Nrf2 (show GABPA ELISA Kits)-mediated oxidative stress response through a physical and catalytically independent interaction with DJ1 at chromatin.
Sensitivity of breast cancer cells to adriamycin was significantly improved with the transfection of DJ-1 siRNA.
Our study suggests that DJ-1 may also play a role in regulating dopamine levels by modifying DAT (show SLC6A3 ELISA Kits) activity.
High expression of PARK7 might lead to the occurrence of non-small-cell lung cancer.
DJ-1 physically binds the 20S proteasome (show PSMA5 ELISA Kits) and inhibits its activity. following oxidative stress, DJ-1 is involved in the Nrf2 (show GABPA ELISA Kits)-dependent oxidative stress response that leads to the upregulation of both the 20S proteasome (show PSMA5 ELISA Kits) and its regulator, NQO1 (show NQO1 ELISA Kits).
DJ-1 protein may be involved in endometrial cells proliferation, migration and angiogenesis by modulating the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/p-mTOR (show FRAP1 ELISA Kits) signaling pathway, which provides an underlying theoretical target for endometriosis and adenomyosis
The DJ-1-induced PTEN downregulation is associated with proliferative and invasive activity of laryngeal cancer cells.
our results maintain that DJ-1 plays a role in the disease process and promotes the necessity of further investigation of DJ-1 as a therapeutic target for ALS.
The PARK7 gene was demonstrated to be located on porcine chromosome 6
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
, parkinson disease protein 7 homolog
, protein DJ-1
, Parkinson disease 7
, RNA-binding protein regulatory subunit
, Parkinson disease (autosomal recessive, early onset) 7
, oncogene DJ1
, contraception-associated protein 1
, fertility protein SP22