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The product of PARK7 belongs to the peptidase C56 family of proteins. Additionally we are shipping PARK7 Antibodies (242) and PARK7 Kits (17) and many more products for this protein.
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Human PARK7 Protein expressed in Escherichia coli (E. coli) - ABIN667043
Choi, Sullards, Olzmann, Rees, Weintraub, Bostwick, Gearing, Levey, Chin, Li: Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. in The Journal of biological chemistry 2006
Show all 2 references for ABIN667043
These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons.
DJ-1(-/-) astrocytes may provide decreased neuroprotection to surrounding neurons due to alterations in pro-inflammatory mediator expression
Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism.
To verify our finding, we provide evidence that the protein expression of Parkinson protein 7, including new protein synthesis, is sensitive to mTORC1 inhibition
These observations reveal an unexpected differential role of DJ-1 in the development of nTregs and iTregs.
A comprehensive analysis of influence of the Parkinson disease-associated genes Parkin (show PARK2 Proteins) and DJ-1 on neurotransmitter receptor (show GRIN1 Proteins) expression in mice
this study identified the anti-oxidant protein DJ-1 as being capable of protecting pancreatic islet cells from cell death induced by an inflammatory and cytotoxic setting.
In skeletal muscle cells, DJ-1 contributes to undernutrition-induced atrophy via MAPKs/ubiquitin ligase pathway.
Deficiency of DJ-1 exerts a stimulatory effect on vascular smooth muscle cell migration.
DJ1 maintains cellular metabolic homeostasis via modulating ROS (show ROS1 Proteins) levels in murine skeletal muscles, revealing a role of DJ1 in maintaining efficient fuel utilization.
DJ-1 physically binds the 20S proteasome (show PSMA5 Proteins) and inhibits its activity. following oxidative stress, DJ-1 is involved in the Nrf2 (show NFE2L2 Proteins)-dependent oxidative stress response that leads to the upregulation of both the 20S proteasome (show PSMA5 Proteins) and its regulator, NQO1 (show NQO1 Proteins).
Serum levels of thioredoxin (show TXN Proteins) and DJ-1 were significantly higher in non-small cell lung cancer patients; therefore, these may be utilized as novel diagnostic and prognostic biomarkers for non-small cell lung cancer
The L10P DJ-1 mutation results in a toxic protein, which lacks the protective function of wild-type protein on mitochondria due to the decrease in the ability of anti-oxidative stress
DJ-1 is increased in elderly lung cancer patients with malignant pleural effusions and may have a role in redox regulation
DJ-1 deglycase plays a major role in preventing protein glycation in eukaryotic cells and might be important for preventing skin glycation
S. pombe homologs of DJ-1 are stationary-phase associated proteins.
these findings demonstrate that SETD6 (show SETD6 Proteins) negatively regulates the Nrf2 (show GABPA Proteins)-mediated oxidative stress response through a physical and catalytically independent interaction with DJ1 at chromatin.
Sensitivity of breast cancer cells to adriamycin was significantly improved with the transfection of DJ-1 siRNA.
Our study suggests that DJ-1 may also play a role in regulating dopamine levels by modifying DAT (show SLC6A3 Proteins) activity.
High expression of PARK7 might lead to the occurrence of non-small-cell lung cancer.
DJ-1 physically binds the 20S proteasome (show PSMA5 Proteins) and inhibits its activity. following oxidative stress, DJ-1 is involved in the Nrf2 (show GABPA Proteins)-dependent oxidative stress response that leads to the upregulation of both the 20S proteasome (show PSMA5 Proteins) and its regulator, NQO1 (show NQO1 Proteins).
The PARK7 gene was demonstrated to be located on porcine chromosome 6
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
, parkinson disease protein 7 homolog
, protein DJ-1
, Parkinson disease 7
, RNA-binding protein regulatory subunit
, Parkinson disease (autosomal recessive, early onset) 7
, oncogene DJ1
, contraception-associated protein 1
, fertility protein SP22