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Patatin-Like phospholipase Domain Containing 2 Proteins (PNPLA2)

PNPLA2 encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Additionally we are shipping Patatin-Like phospholipase Domain Containing 2 Antibodies (156) and Patatin-Like phospholipase Domain Containing 2 Kits (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PNPLA2 57104 Q96AD5
PNPLA2 66853 Q8BJ56
PNPLA2 361676 P0C548
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Top Patatin-Like phospholipase Domain Containing 2 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,349.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,375.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PNPLA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced Patatin-Like phospholipase Domain Containing 2 Proteins

  1. Human PNPLA2 Protein expressed in Wheat germ - ABIN1315583 : Tavian, Missaglia, Redaelli, Pennisi, Invernici, Wessalowski, Maiwald, Arca, Coleman: Contribution of novel ATGL missense mutations to the clinical phenotype of NLSD-M: a strikingly low amount of lipase activity may preserve cardiac function. in Human molecular genetics 2012 (PubMed)

More Proteins for Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaction Partners

Goat Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. the ATGL gene plays an important role in triglyceride lipolysis in GMECs; ATGL may be involved in lipid metabolism during lactation

Human Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. Data indicate that a tumor suppressor mechanism by which G0/G1 switch gene 2 (show G0S2 Proteins) product (G0S2 (show G0S2 Proteins)) directly inhibits activity of a key intracellular adipose triglyceride lipase (ATGL).

  2. Authors show that rat ATGL, coactivated by rat CGI-58 (show ABHD5 Proteins), efficiently hydrolyzes triglycerides and retinyl ester.

  3. PNPLA2 mutations were associated with an extended phenotype, including brain involvement in cases of neutral lipid-storage disease with myopathy.

  4. Distinct cardiac phenotype between two homozygotes born in a village with accumulation of a genetic deficiency of adipose triglyceride lipase.

  5. ANGPTL8 is a stress-response protein that down-regulates expression of ATGL.

  6. Study reports the clinical and genetic findings of a neutral lipid storage disease with myopathy family of Italian origin with 3 affected siblings. to highlight the effect that different gene mutations may have on ATGL lipase (show LIPG Proteins) activity, authors performed a functional characterization of the novel PNPLA2 missense mutations identified in their patients

  7. PLIN5 (show PLIN5 Proteins) was significantly colocated with ATGL, mitochondria and CGI-58 (show ABHD5 Proteins), indicating a close association between the key lipolytic effectors in resting skeletal muscle.

  8. PEDF (show SERPINF1 Proteins) receptor is a transmembrane phospholipase that is required for the survival and antiapoptotic effects of PEDF (show SERPINF1 Proteins) on retina cells. It has determinants for PEDF (show SERPINF1 Proteins) binding within its L4 ectodomain that are critical for enzymatic stimulation.

  9. Data suggest that PNPLA2 hydrolyzes arachidonic acid from triglycerides in mast cell (MC) lipid droplets; PNPLA2 appears to regulate substrate availability of AA for eicosanoid (PGD2/LTC4) generation/secretion upon MC activation with IgE.

  10. Data suggest that pigment epithelium-derived factor (PEDF (show SERPINF1 Proteins)) and adipose triglyceride lipase (ATGL) may serve as therapeutic targets for managing vascular hyperpermeability in sepsis.

Mouse (Murine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. ANGPTL8 is a stress-response protein that down-regulates expression of ATGL.

  2. ATGL KO mice had significantly lower fasting plasma free fatty-acids compared to WT. Fasting endogenous glucose production and peripheral glucose metabolism were similar in KO and WT mice.

  3. Pharmacological inhibition of ATGL may prove useful to prevent HFD-induced obesity and insulin (show INS Proteins) resistance

  4. A role for Atgl in kidney lipolysis:fasting up-regulates Atgl levels and phosphorylation in mouse kidney.

  5. data provide mechanistic insights into Jordans' anomaly in neutrophils and suggest that ATGL is a potent regulator of immune cell function and inflammatory diseases.

  6. Data show that obese adipocyte-specific adipose triglyceride lipase (ATGL) knockout (AAKO) mice had reduced adipocyte lipolysis.

  7. transcriptional transactivation assays with a luciferase reporter system revealed that Fabps enhance the ability of Atgl/Cgi-58 (show ABHD5 Proteins)-mediated lipolysis to induce the activity of peroxisome proliferator-activated receptors.

  8. Data (including data from studies in atherosclerotic knockout mice) suggest CGI58- (abhydrolase domain containing 5 (show ABHD5 Proteins)-)deficient macrophages store-up triglyceride droplets and have reduced phagocytic capacity, comparable to Atgl-deficient macrophages.

  9. Data suggest that cardiotrophin-1 (show CTF1 Proteins) up-regulates lipolysis in white adipocytes via 1) induction of perilipin (show PLIN1 Proteins), 2) activation of hormone sensitive lipase (show LIPE Proteins) (via phosphorylation by PKA), and 3) inactivation of ATGL (via up-regulation of its inhibitor G0S2 (show G0S2 Proteins)).

  10. 4E-BP1 (show EIF4EBP1 Proteins)/2-null cells express less ATGL and accumulate more fat than control cells, while knock down of Egr1 (show EGR1 Proteins) in 4E-BP1 (show EIF4EBP1 Proteins)/2-null cells increases ATGL expression and decreases fat storage.

Pig (Porcine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. Resveratrol activated sirtuin 1 (Sirt1 (show SIRT1 Proteins)) gene expression and increased adipose triglyceride lipase (ATGL) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (show SIRT1 Proteins) regulation pattern for PPARgamma (show PPARG Proteins) to that of ATGL in adipocytes.

  2. analysis of porcine adipose triglyceride lipase (PNPLA2) gene

  3. JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) and MAPK (show MAPK1 Proteins) signaling pathways, as well as PPAR gamma (show PPARG Proteins) all played important roles in the ATGL expression mediated by leptin (show LEP Proteins)

  4. patatin-like phospholipase domain containing 2 gene (PNPLA2) is assiged to chromosome 2 in pigs.

  5. ATGL expression reacts to hormonal stimuli and plays a role in catecholamine-induced lipolysis in porcine adipose tissue.

Cow (Bovine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. Tissue distribution of ATGL gene expression was highest in fat and muscle (skeletal and cardiac) tissue, while protein expression was solely detectible in the adipose tissue.

Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Protein Profile

Protein Summary

This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.

Gene names and symbols associated with PNPLA2

  • patatin-like phospholipase domain containing 3 (pnpla3)
  • patatin-like phospholipase domain containing 2 (PNPLA2)
  • patatin-like phospholipase domain containing 2 (pnpla2)
  • adipose triglyceride lipase (ATGL)
  • patatin-like phospholipase domain containing 2 (Pnpla2)
  • 0610039C21Rik protein
  • 1110001C14Rik protein
  • Atgl protein
  • iPLA2zeta protein
  • PEDF-R protein
  • pnpla2 protein
  • RGD1309044 protein
  • TTS-2.2 protein
  • TTS2 protein
  • zgc:92195 protein

Protein level used designations for PNPLA2

patatin-like phospholipase domain-containing protein 2 , patatin-like phospholipase domain containing 2 , adipose triglyceride lipase , IPLA2-zeta , TTS2.2 , calcium-independent phospholipase A2 , desnutrin , patatin-like phospholipase domain containing protein 2 , pigment epithelium-derived factor , transport-secretion protein 2.2 , triglyceride hydrolase , transport-secretion protein , PNPLA2/ATGL

GENE ID SPECIES
436610 Danio rerio
611403 Canis lupus familiaris
780152 Xenopus (Silurana) tropicalis
100219060 Taeniopygia guttata
100294555 Meleagris gallopavo
100860889 Capra hircus
57104 Homo sapiens
66853 Mus musculus
100049704 Sus scrofa
508493 Bos taurus
431066 Gallus gallus
361676 Rattus norvegicus
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